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    F2RL1 F2R like trypsin receptor 1 [ Homo sapiens (human) ]

    Gene ID: 2150, updated on 13-Jun-2016
    Official Symbol
    F2RL1provided by HGNC
    Official Full Name
    F2R like trypsin receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:3538
    See related
    Ensembl:ENSG00000164251 HPRD:02960; MIM:600933; Vega:OTTHUMG00000102118
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAR2; GPR11
    Summary
    Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    5q13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (76819008..76835315)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (76114833..76131140)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene non-protein coding RNA, upstream of F2R/PAR1 Neighboring gene coagulation factor II thrombin receptor Neighboring gene RNA, 7SL, cytoplasmic 208, pseudogene Neighboring gene S100 calcium binding protein Z Neighboring gene RNA, U6atac small nuclear 36, pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • African trypanosomiasis, organism-specific biosystem (from KEGG)
      African trypanosomiasis, organism-specific biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
    • African trypanosomiasis, conserved biosystem (from KEGG)
      African trypanosomiasis, conserved biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
    • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
      Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
    • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
      Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
    • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
      Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein alpha-subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    G-protein beta-subunit binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    G-protein coupled receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    G-protein coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    thrombin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    T cell activation involved in immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    chemokine (C-C motif) ligand 2 secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chemokine secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    establishment of endothelial barrier IDA
    Inferred from Direct Assay
    more info
    PubMed 
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    interferon-gamma secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    interleukin-1 beta secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interleukin-10 secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukocyte migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukocyte proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mature conventional dendritic cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mature conventional dendritic cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of chemokine secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of toll-like receptor 3 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neutrophil activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of actin filament depolymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cytokine secretion involved in immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of eosinophil degranulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of glomerular filtration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of interleukin-6 secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of interleukin-8 secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of leukocyte chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neutrophil mediated killing of gram-negative bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of phagocytosis, engulfment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of positive chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of pseudopodium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of renin secretion into blood stream ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of superoxide anion generation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of toll-like receptor 2 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of toll-like receptor 3 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of toll-like receptor 4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of vasodilation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of blood coagulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    thrombin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus TAS
    Traceable Author Statement
    more info
    PubMed 
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    pseudopodium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    proteinase-activated receptor 2
    Names
    G-protein coupled receptor 11
    coagulation factor II (thrombin) receptor-like 1
    coagulation factor II receptor-like 1
    protease-activated receptor 2
    thrombin receptor-like 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005242.4NP_005233.3  proteinase-activated receptor 2 precursor

      See identical proteins and their annotated locations for NP_005233.3

      Status: VALIDATED

      Source sequence(s)
      BC012453, BC018130, DB463838
      Consensus CDS
      CCDS4033.1
      UniProtKB/Swiss-Prot
      P55085
      Related
      ENSP00000296677, OTTHUMP00000128315, ENST00000296677, OTTHUMT00000219957
      Conserved Domains (2) summary
      pfam00001
      Location:98344
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:161362
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

      Range
      76819008..76835315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009223.1XP_016864712.1  

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      75547934..75564299
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)