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    ATF3 activating transcription factor 3 [ Homo sapiens (human) ]

    Gene ID: 467, updated on 7-Feb-2016
    Official Symbol
    ATF3provided by HGNC
    Official Full Name
    activating transcription factor 3provided by HGNC
    Primary source
    HGNC:HGNC:785
    See related
    Ensembl:ENSG00000162772; HPRD:04395; MIM:603148; Vega:OTTHUMG00000036747
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]
    Orthologs
    See ATF3 in Epigenomics, MapViewer
    Location:
    1q32.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (212565334..212620777)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (212738676..212794119)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372908 Neighboring gene uncharacterized LOC101929565 Neighboring gene uncharacterized LOC102723761 Neighboring gene uncharacterized LOC105372909 Neighboring gene family with sequence similarity 71 member A

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef Expression of activating transcription factor 3 (ATF-3) is upregulated by HIV-1 Nef in HeLa cells PubMed
    Tat tat HIV-1 and the viral protein Tat modulate the expression of activating transcription factor 3 (ATF3) in immature dendritic cells and monocyte-derived macrophages PubMed
    tat HIV-1 Tat upregulates ATF3 expression in Tat-infected Jurkat T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ41705

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    CHOP-ATF3 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    cyclic AMP-dependent transcription factor ATF-3
    Names
    cAMP-dependent transcription factor ATF-3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029871.1 RefSeqGene

      Range
      4980..60423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001030287.3NP_001025458.1  cyclic AMP-dependent transcription factor ATF-3 isoform 1

      See identical proteins and their annotated locations for NP_001025458.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (1), which represses rather than activates transcription from promoters with ATF-binding elements.
      Source sequence(s)
      AC092803, AI949953, BC006322, CD638624, CD641946, CD742713
      Consensus CDS
      CCDS1506.1
      UniProtKB/Swiss-Prot
      P18847
      Related
      ENSP00000355954, ENST00000366987
      Conserved Domains (1) summary
      cd14722
      Location:96149
      bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain
    2. NM_001040619.2NP_001035709.1  cyclic AMP-dependent transcription factor ATF-3 isoform 2

      See identical proteins and their annotated locations for NP_001035709.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as deltaZip2a) contains an alternate terminal exon, and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2, also known as deltaZip2) has a distinct and shorter C-terminus, compared to isoform 1. Isoform 2 lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter.
      Source sequence(s)
      AB078026, AI949953, AL560585, BC006322, CD742713, DB197400
      Consensus CDS
      CCDS41464.1
      UniProtKB/Swiss-Prot
      P18847
      Conserved Domains (1) summary
      cl21462
      Location:96116
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    3. NM_001206484.2NP_001193413.2  cyclic AMP-dependent transcription factor ATF-3 isoform 3

      See identical proteins and their annotated locations for NP_001193413.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus, compared to isoform 1. Both variants 5 and 8 encode isoform 3.
      Source sequence(s)
      AB078026, AI949953, AL560585, BC006322, CD742713, DA589280
      Consensus CDS
      CCDS58059.1
      UniProtKB/Swiss-Prot
      P18847
      Conserved Domains (1) summary
      cd14722
      Location:3992
      bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain
    4. NM_001206486.2NP_001193415.1  cyclic AMP-dependent transcription factor ATF-3 isoform 5

      See identical proteins and their annotated locations for NP_001193415.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks an in-frame segment of the 5' coding region, and contains an alternate terminal exon, thus differing in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (5, also known as deltaZip2c) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AB078026, AI949953, AY313927, BC006322, CD742713
      Consensus CDS
      CCDS55688.1
      UniProtKB/Swiss-Prot
      P18847
      Conserved Domains (1) summary
      cl21462
      Location:6787
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    5. NM_001206488.2NP_001193417.2  cyclic AMP-dependent transcription factor ATF-3 isoform 3

      See identical proteins and their annotated locations for NP_001193417.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus, compared to isoform 1. Both variants 5 and 8 encode isoform 3.
      Source sequence(s)
      AI949953, AL560585, BC006322, BI524020, CD742713
      Consensus CDS
      CCDS58059.1
      UniProtKB/Swiss-Prot
      P18847
      Related
      ENSP00000483576, ENST00000613954
      Conserved Domains (1) summary
      cd14722
      Location:3992
      bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain
    6. NM_001674.3NP_001665.1  cyclic AMP-dependent transcription factor ATF-3 isoform 1

      See identical proteins and their annotated locations for NP_001665.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1), which represses rather than activates transcription from promoters with ATF-binding elements. Both variants 1 and 3 encode isoform 1.
      Source sequence(s)
      AI949953, AL560585, BC006322, CD742713
      Consensus CDS
      CCDS1506.1
      UniProtKB/Swiss-Prot
      P18847
      Related
      ENSP00000344352, OTTHUMP00000034887, ENST00000341491, OTTHUMT00000089296
      Conserved Domains (1) summary
      cd14722
      Location:96149
      bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

      Range
      212565334..212620777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509579.1XP_011507881.1  

      See identical proteins and their annotated locations for XP_011507881.1

      UniProtKB/Swiss-Prot
      P18847
      Conserved Domains (1) summary
      cd14722
      Location:96149
      bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain
    2. XM_005273146.1XP_005273203.1  

      See identical proteins and their annotated locations for XP_005273203.1

      UniProtKB/Swiss-Prot
      P18847
      Conserved Domains (1) summary
      cd14722
      Location:96149
      bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      214011558..214066986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001206485.1: Suppressed sequence

      Description
      NM_001206485.1: This RefSeq was permanently suppressed because the transcript is incompletely processed.
    2. NM_004024.4: Suppressed sequence

      Description
      NM_004024.4: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.