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    Thbd thrombomodulin [ Mus musculus (house mouse) ]

    Gene ID: 21824, updated on 8-Aug-2016
    Official Symbol
    Thbdprovided by MGI
    Official Full Name
    thrombomodulinprovided by MGI
    Primary source
    MGI:MGI:98736
    See related
    Ensembl:ENSMUSG00000074743 Vega:OTTMUSG00000015710
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TM; CD141; AI385582
    Orthologs
    Location:
    2 G3; 2 73.45 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (148404471..148408188, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (148230207..148233924, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39957 Neighboring gene somatostatin receptor 4 Neighboring gene CD93 antigen Neighboring gene uncharacterized LOC108168804

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    blood coagulation TAS
    Traceable Author Statement
    more info
    PubMed 
    embryo development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    female pregnancy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hemostasis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of coagulation TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    apicolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    vacuolar membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    thrombomodulin
    Names
    fetomodulin
    snoRNA MBII-339

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009378.3NP_033404.1  thrombomodulin precursor

      See identical proteins and their annotated locations for NP_033404.1

      Status: VALIDATED

      Source sequence(s)
      AL935149
      Consensus CDS
      CCDS16838.1
      UniProtKB/Swiss-Prot
      P15306
      UniProtKB/TrEMBL
      Q543W3
      Related
      ENSMUSP00000096877, OTTMUSP00000016721, ENSMUST00000099270, OTTMUST00000037329
      Conserved Domains (5) summary
      pfam09064
      Location:405438
      Tme5_EGF_like; Thrombomodulin like fifth domain, EGF-like
      cd00054
      Location:324356
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam06247
      Location:346467
      Plasmod_Pvs28; Plasmodium ookinete surface protein Pvs28
      pfam14670
      Location:244279
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl02432
      Location:30169
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      148404471..148408188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)