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RBM3 RNA binding motif (RNP1, RRM) protein 3 [ Homo sapiens (human) ]

Gene ID: 5935, updated on 7-Dec-2014
Official Symbol
RBM3provided by HGNC
Official Full Name
RNA binding motif (RNP1, RRM) protein 3provided by HGNC
Primary source
HGNC:HGNC:9900
See related
HPRD:02067; MIM:300027
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNPL; IS1-RNPL
Summary
This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Multiple alternatively spliced transcript variants that are predicted to encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2008]
See RBM3 in Epigenomics, MapViewer
Location:
Xp11.2
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) X NC_000023.11 (48574353..48581165)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (48432741..48439553)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene emopamil binding protein (sterol isomerase) Neighboring gene TBC1 domain family, member 25 Neighboring gene mitochondrial ribosomal protein L32 pseudogene 1 Neighboring gene WD repeat domain 13

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding TAS
Traceable Author Statement
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribosomal large subunit binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA processing TAS
Traceable Author Statement
more info
PubMed 
positive regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
 
production of miRNAs involved in gene silencing by miRNA IEA
Inferred from Electronic Annotation
more info
 
regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
 
response to cold IEA
Inferred from Electronic Annotation
more info
 
translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with large ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
putative RNA-binding protein 3
Names
putative RNA-binding protein 3
RNA-binding motif protein 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006743.4NP_006734.1  putative RNA-binding protein 3

    See proteins identical to NP_006734.1

    Status: REVIEWED

    Source sequence(s)
    AC115618, BC006825
    Consensus CDS
    CCDS14301.1
    UniProtKB/TrEMBL
    A0A024QYX3
    UniProtKB/Swiss-Prot
    P98179
    Conserved Domains (2) summary
    cd12449
    Location:685
    RRM_CIRBP_RBM3; RNA recognition motif in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins
    pfam14259
    Location:878
    RRM_6; RNA recognition motif (a.k.a. RRM, RBD, or RNP domain)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000023.11 

    Range
    48574353..48581165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 

    Range
    48463982..48470795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000155.1 

    Range
    46096108..46133256
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001017430.1: Suppressed sequence

    Description
    NM_001017430.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_001017431.1: Suppressed sequence

    Description
    NM_001017431.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.