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Acox1 acyl-Coenzyme A oxidase 1, palmitoyl [ Mus musculus (house mouse) ]

Gene ID: 11430, updated on 30-Jun-2014
Official Symbol
Acox1provided by MGI
Official Full Name
acyl-Coenzyme A oxidase 1, palmitoylprovided by MGI
Primary source
MGI:1330812
Locus tag
RP23-42F6.11-001
See related
Ensembl:ENSMUSG00000020777; Vega:OTTMUSG00000003754
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AOX; Acox; Paox; D130055E20Rik
Summary
This gene encodes a member of the acyl-coenzyme A oxidase family. The encoded protein is localized to peroxisomes and is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-coenzyme A to 2-trans-enoyl-coenzyme A. Disruption of this gene results in microvesicular steatohepatitis, spontaneous peroxisome proliferation, and the eventual development of hepatocellular carcinomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
See Acox1 in Epigenomics, MapViewer
Location:
11 E2; 11
Exon count :
15
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 11 NC_000077.6 (116171883..116199045, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L38 Neighboring gene Fas (TNFRSF6) binding factor 1 Neighboring gene TEN1 telomerase capping complex subunit Neighboring gene cyclin-dependent kinase 3, pseudogene Neighboring gene uncharacterized LOC102636223 Neighboring gene envoplakin

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
FAD binding ISO
Inferred from Sequence Orthology
more info
 
PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
acyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
acyl-CoA oxidase activity ISO
Inferred from Sequence Orthology
more info
 
acyl-CoA oxidase activity TAS
Traceable Author Statement
more info
PubMed 
fatty acid binding ISO
Inferred from Sequence Orthology
more info
 
flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
 
palmitoyl-CoA oxidase activity ISO
Inferred from Sequence Orthology
more info
 
protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
fatty acid beta-oxidation TAS
Traceable Author Statement
more info
PubMed 
fatty acid beta-oxidation using acyl-CoA oxidase ISO
Inferred from Sequence Orthology
more info
 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
fatty acid oxidation IMP
Inferred from Mutant Phenotype
more info
 
fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
generation of precursor metabolites and energy ISO
Inferred from Sequence Orthology
more info
 
lipid homeostasis ISO
Inferred from Sequence Orthology
more info
 
lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
peroxisome fission ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
prostaglandin metabolic process ISO
Inferred from Sequence Orthology
more info
 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
very long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
peroxisomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
peroxisome ISO
Inferred from Sequence Orthology
more info
 
peroxisome TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
peroxisomal acyl-coenzyme A oxidase 1
Names
peroxisomal acyl-coenzyme A oxidase 1
palmitoyl-CoA oxidase
peroxisomal fatty acyl-coenzyme A oxidase
peroxisomal straight-chain Acyl-CoA oxidase
NP_001258827.1
NP_056544.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271898.1NP_001258827.1  peroxisomal acyl-coenzyme A oxidase 1 isoform 2

    See proteins identical to NP_001258827.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is the same length as isoform 1.
    Source sequence(s)
    AL607108, AL669925, BC056448
    Consensus CDS
    CCDS70354.1
    UniProtKB/Swiss-Prot
    Q9R0H0
    Related
    ENSMUSP00000072717, OTTMUSP00000003996, ENSMUST00000072948, OTTMUST00000008213
    Conserved Domains (2) summary
    cd01150
    Location:3638
    Blast Score: 2305
    AXO; Peroxisomal acyl-CoA oxidase
    PLN02443
    Location:5657
    Blast Score: 1704
    PLN02443; acyl-coenzyme A oxidase
  2. NM_015729.3NP_056544.2  peroxisomal acyl-coenzyme A oxidase 1 isoform 1

    See proteins identical to NP_056544.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL607108, BC056448
    Consensus CDS
    CCDS25660.1
    UniProtKB/Swiss-Prot
    Q9R0H0
    Related
    ENSMUSP00000063325, OTTMUSP00000003995, ENSMUST00000066587, OTTMUST00000008212
    Conserved Domains (2) summary
    cd01150
    Location:3638
    Blast Score: 2363
    AXO; Peroxisomal acyl-CoA oxidase
    PLN02443
    Location:5657
    Blast Score: 1707
    PLN02443; acyl-coenzyme A oxidase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000077.6 

    Range
    116171883..116199045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532002.1XP_006532065.1  

    Related
    ENSMUSP00000122185, OTTMUSP00000003997, ENSMUST00000148601, OTTMUST00000008214
    Conserved Domains (1) summary
    cd01150
    Location:23570
    Blast Score: 2083
    AXO; Peroxisomal acyl-CoA oxidase

Alternate Mm_Celera

Genomic

  1. AC_000033.1 

    Range
    127936002..127963704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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