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Vldlr very low density lipoprotein receptor [ Mus musculus (house mouse) ]

Gene ID: 22359, updated on 24-Jan-2015
Official Symbol
Vldlrprovided by MGI
Official Full Name
very low density lipoprotein receptorprovided by MGI
Primary source
MGI:MGI:98935
See related
Ensembl:ENSMUSG00000024924; Vega:OTTMUSG00000035962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AA408956; AI451093; AW047288
Orthologs
See Vldlr in MapViewer
Location:
19 C1; 19 21.77 cM
Exon count:
19
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 19 NC_000085.6 (27216489..27254231)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35483 Neighboring gene predicted gene, 35438 Neighboring gene predicted gene 3916 Neighboring gene predicted gene, 35268 Neighboring gene potassium channel, subfamily V, member 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
apolipoprotein binding ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
glycoprotein binding ISO
Inferred from Sequence Orthology
more info
 
glycoprotein transporter activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
reelin receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
very-low-density lipoprotein particle binding ISO
Inferred from Sequence Orthology
more info
 
very-low-density lipoprotein particle receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
glycoprotein transport ISO
Inferred from Sequence Orthology
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of dendrite development IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
reelin-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
very-low-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
apical part of cell ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
coated pit IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
very-low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
very low-density lipoprotein receptor
Names
very low-density lipoprotein receptor
VLDL-R
VLDL receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161420.1NP_001154892.1  very low-density lipoprotein receptor isoform b precursor

    See proteins identical to NP_001154892.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC119982, AK036010, AK076172, AK136838, BU504025, U06670
    Consensus CDS
    CCDS50411.1
    UniProtKB/Swiss-Prot
    P98156
    UniProtKB/TrEMBL
    Q3UVX6
    UniProtKB/TrEMBL
    Q91YY0
    Conserved Domains (5) summary
    smart00135
    Location:508547
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00054
    Location:396426
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00112
    Location:3367
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:568608
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:360394
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  2. NM_013703.2NP_038731.2  very low-density lipoprotein receptor isoform a precursor

    See proteins identical to NP_038731.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer variant and encodes the longer isoform (a).
    Source sequence(s)
    AC119982, AK036010, AK076172, AK136838, BU504025, U06670
    Consensus CDS
    CCDS29721.1
    UniProtKB/Swiss-Prot
    P98156
    UniProtKB/TrEMBL
    Q3UVX6
    Related
    ENSMUSP00000127329, OTTMUSP00000050945, ENSMUST00000167487, OTTMUST00000092260
    Conserved Domains (5) summary
    smart00135
    Location:592634
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00054
    Location:396426
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00112
    Location:3367
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:568608
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:360394
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000085.6 

    Range
    27216489..27254231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526917.1XP_006526980.1  

    See proteins identical to XP_006526980.1

    UniProtKB/Swiss-Prot
    P98156
    Conserved Domains (5) summary
    smart00135
    Location:592634
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00054
    Location:396426
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00112
    Location:3367
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:568608
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:360394
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  2. XM_006526919.1XP_006526982.1  

    Conserved Domains (5) summary
    smart00135
    Location:467506
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00054
    Location:355385
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00112
    Location:3367
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:527567
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:319353
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  3. XM_006526918.1XP_006526981.1  

    See proteins identical to XP_006526981.1

    UniProtKB/Swiss-Prot
    P98156
    Conserved Domains (5) summary
    smart00135
    Location:592634
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00054
    Location:396426
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00112
    Location:3367
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:568608
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:360394
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  4. XM_006526920.1XP_006526983.1  

    Conserved Domains (5) summary
    smart00135
    Location:488530
    LY; Low-density lipoprotein-receptor YWTD domain
    cd00054
    Location:292322
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00112
    Location:135169
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00058
    Location:464504
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:256290
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RNA

  1. XR_386456.1 RNA Sequence

  2. XR_386457.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000041.1 

    Range
    28001119..28038314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)