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Thrb thyroid hormone receptor beta [ Mus musculus (house mouse) ]

Gene ID: 21834, updated on 20-Dec-2014
Official Symbol
Thrbprovided by MGI
Official Full Name
thyroid hormone receptor betaprovided by MGI
Primary source
MGI:MGI:98743
See related
Ensembl:ENSMUSG00000021779; Vega:OTTMUSG00000023243
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nr1a2; Thrb1; Thrb2; T3R[b]; T3Rbeta; c-erbAbeta
See Thrb in Epigenomics, MapViewer
Location:
14; 14 A3
Exon count:
21
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 14 NC_000080.6 (17659843..18038090)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32121 Neighboring gene predicted gene, 32187 Neighboring gene predicted gene, 32269 Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC141269, MGC141270

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
steroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
thyroid hormone binding ISO
Inferred from Sequence Orthology
more info
 
thyroid hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
thyroid hormone receptor activity TAS
Traceable Author Statement
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Type I pneumocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
female courtship behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
intracellular receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
negative regulation of female receptivity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
regulation of triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
 
sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
thyroid hormone receptor beta
Names
thyroid hormone receptor beta
TR beta
c-erbA-2
c-erbA-beta
nuclear receptor subfamily 1 group A member 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113417.1NP_001106888.1  thyroid hormone receptor beta isoform 1

    See proteins identical to NP_001106888.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains a distinct 5' UTR and multiple 5' coding region differences, compared to variant 2. Codons 1-94 of this variant are encoded by exons that are not present in variant 2. The encoded protein (isoform 1) is identical to isoform 2 in the C-terminus.
    Source sequence(s)
    AC154626, AC154681, AK133662, AK158826
    Consensus CDS
    CCDS49404.1
    UniProtKB/Swiss-Prot
    P37242
    UniProtKB/TrEMBL
    Q3UZT5
    Related
    ENSMUSP00000089053, ENSMUST00000091471
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  2. NM_009380.3NP_033406.1  thyroid hormone receptor beta isoform 2

    See proteins identical to NP_033406.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longer isoform (2).
    Source sequence(s)
    AC154626, AC154681, BC089035
    Consensus CDS
    CCDS26835.1
    UniProtKB/Swiss-Prot
    P37242
    Related
    ENSMUSP00000022304, OTTMUSP00000027025, ENSMUST00000022304, OTTMUST00000056280
    Conserved Domains (2) summary
    cd06935
    Location:230472
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:120206
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000080.6 

    Range
    17659843..18038090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517961.1XP_006518024.1  

    See proteins identical to XP_006518024.1

    Conserved Domains (2) summary
    cd06935
    Location:224466
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:114200
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  2. XM_006517973.1XP_006518036.1  

    Conserved Domains (2) summary
    cd06935
    Location:213455
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:103189
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  3. XM_006517974.1XP_006518037.1  

    Conserved Domains (2) summary
    cd06935
    Location:185427
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:75161
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  4. XM_006517970.1XP_006518033.1  

    See proteins identical to XP_006518033.1

    UniProtKB/Swiss-Prot
    P37242
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  5. XM_006517964.1XP_006518027.1  

    See proteins identical to XP_006518027.1

    Conserved Domains (2) summary
    cd06935
    Location:224466
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:114200
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  6. XM_006517967.1XP_006518030.1  

    See proteins identical to XP_006518030.1

    UniProtKB/Swiss-Prot
    P37242
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  7. XM_006517958.1XP_006518021.1  

    Conserved Domains (2) summary
    cd06935
    Location:305547
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:195281
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  8. XM_006517960.1XP_006518023.1  

    See proteins identical to XP_006518023.1

    Conserved Domains (2) summary
    cd06935
    Location:224466
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:114200
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  9. XM_006517966.1XP_006518029.1  

    See proteins identical to XP_006518029.1

    UniProtKB/Swiss-Prot
    P37242
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  10. XM_006517962.1XP_006518025.1  

    See proteins identical to XP_006518025.1

    Conserved Domains (2) summary
    cd06935
    Location:224466
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:114200
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  11. XM_006517968.1XP_006518031.1  

    See proteins identical to XP_006518031.1

    UniProtKB/Swiss-Prot
    P37242
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  12. XM_006517963.1XP_006518026.1  

    See proteins identical to XP_006518026.1

    Conserved Domains (2) summary
    cd06935
    Location:224466
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:114200
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  13. XM_006517959.1XP_006518022.1  

    Conserved Domains (2) summary
    cd06935
    Location:246488
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:136222
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  14. XM_006517969.1XP_006518032.1  

    See proteins identical to XP_006518032.1

    UniProtKB/Swiss-Prot
    P37242
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  15. XM_006517965.1XP_006518028.1  

    See proteins identical to XP_006518028.1

    Conserved Domains (2) summary
    cd06935
    Location:224466
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:114200
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  16. XM_006517972.1XP_006518035.1  

    See proteins identical to XP_006518035.1

    UniProtKB/Swiss-Prot
    P37242
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
  17. XM_006517971.1XP_006518034.1  

    See proteins identical to XP_006518034.1

    UniProtKB/Swiss-Prot
    P37242
    Conserved Domains (2) summary
    cd06935
    Location:216458
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:106192
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

Alternate Mm_Celera

Genomic

  1. AC_000036.1 

    Range
    13338110..13729284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)