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Apoe apolipoprotein E [ Mus musculus (house mouse) ]

Gene ID: 11816, updated on 23-Jul-2014
Official Symbol
Apoeprovided by MGI
Official Full Name
apolipoprotein Eprovided by MGI
Primary source
MGI:88057
See related
Ensembl:ENSMUSG00000002985; Vega:OTTMUSG00000038239
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI255918
See Apoe in Epigenomics, MapViewer
Location:
7 A3; 7 9.94 cM
Exon count:
4
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 7 NC_000073.6 (19696244..19699166, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene apolipoprotein C-IV Neighboring gene apolipoprotein C-I Neighboring gene translocase of outer mitochondrial membrane 40 homolog (yeast) Neighboring gene uncharacterized LOC102638223 Neighboring gene poliovirus receptor-related 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
antioxidant activity ISO
Inferred from Sequence Orthology
more info
 
beta-amyloid binding ISO
Inferred from Sequence Orthology
more info
 
cholesterol transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
heparin binding ISO
Inferred from Sequence Orthology
more info
 
hydroxyapatite binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
lipid binding ISO
Inferred from Sequence Orthology
more info
 
lipid transporter activity ISO
Inferred from Sequence Orthology
more info
 
lipoprotein particle binding IDA
Inferred from Direct Assay
more info
PubMed 
low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
 
metal chelating activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylcholine-sterol O-acyltransferase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylcholine-sterol O-acyltransferase activator activity ISO
Inferred from Sequence Orthology
more info
 
phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
tau protein binding ISO
Inferred from Sequence Orthology
more info
 
very-low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
N-methyl-D-aspartate receptor clustering ISO
Inferred from Sequence Orthology
more info
 
aging ISO
Inferred from Sequence Orthology
more info
 
alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering ISO
Inferred from Sequence Orthology
more info
 
artery morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT axon regeneration IGI
Inferred from Genetic Interaction
more info
PubMed 
cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
cardiovascular system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
cholesterol homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
chylomicron remnant clearance ISO
Inferred from Sequence Orthology
more info
 
fatty acid homeostasis ISO
Inferred from Sequence Orthology
more info
 
high-density lipoprotein particle assembly ISO
Inferred from Sequence Orthology
more info
 
high-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
high-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
 
lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
lipid transport ISO
Inferred from Sequence Orthology
more info
 
lipoprotein biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
lipoprotein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipoprotein metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
lipoprotein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
 
long-chain fatty acid transport ISO
Inferred from Sequence Orthology
more info
 
low-density lipoprotein particle remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
maintenance of location in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of beta-amyloid formation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
negative regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of dendritic spine maintenance ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
 
negative regulation of lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of lipid transport across blood brain barrier ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of phospholipid efflux ISO
Inferred from Sequence Orthology
more info
 
negative regulation of platelet activation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of postsynaptic membrane organization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of presynaptic membrane organization ISO
Inferred from Sequence Orthology
more info
 
nitric oxide mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
phospholipid efflux ISO
Inferred from Sequence Orthology
more info
 
positive regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
positive regulation of beta-amyloid formation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cGMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of catalytic activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cholesterol esterification IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cholesterol esterification ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendritic spine maintenance ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lipid transport across blood brain barrier ISO
Inferred from Sequence Orthology
more info
 
positive regulation of low-density lipoprotein particle receptor catabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neurofibrillary tangle assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric-oxide synthase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phospholipid efflux ISO
Inferred from Sequence Orthology
more info
 
positive regulation of postsynaptic membrane organization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of presynaptic membrane organization ISO
Inferred from Sequence Orthology
more info
 
protein import ISO
Inferred from Sequence Orthology
more info
 
NOT protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of Cdc42 protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
regulation of beta-amyloid clearance ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
regulation of tau-protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
response to dietary excess IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
reverse cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
 
vasodilation IMP
Inferred from Mutant Phenotype
more info
PubMed 
very-low-density lipoprotein particle clearance ISO
Inferred from Sequence Orthology
more info
 
very-low-density lipoprotein particle remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
very-low-density lipoprotein particle remodeling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
blood microparticle ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
chylomicron ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
discoidal high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with early endosome ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endosome ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
intermediate-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
late endosome ISO
Inferred from Sequence Orthology
more info
 
low-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
lysosome ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
very-low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
apolipoprotein E
Names
apolipoprotein E
apo-E

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009696.3NP_033826.2  apolipoprotein E precursor

    See proteins identical to NP_033826.2

    Status: VALIDATED

    Source sequence(s)
    AI836733, AK134921, BY772289
    Consensus CDS
    CCDS20912.1
    UniProtKB/Swiss-Prot
    P08226
    UniProtKB/TrEMBL
    Q3TXU4
    Related
    ENSMUSP00000133302, OTTMUSP00000055344, ENSMUST00000174064, OTTMUST00000098456
    Conserved Domains (3) summary
    pfam01442
    Location:96291
    Blast Score: 355
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    pfam02720
    Location:106244
    Blast Score: 90
    DUF222; Domain of unknown function (DUF222)
    cl03075
    Location:55124
    Blast Score: 83
    GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000073.6 

    Range
    19696244..19699166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539484.1XP_006539547.1  

    Related
    ENSMUSP00000133371, OTTMUSP00000055346, ENSMUST00000173739, OTTMUST00000098458
    Conserved Domains (3) summary
    pfam01442
    Location:140335
    Blast Score: 387
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    pfam02720
    Location:150288
    Blast Score: 93
    DUF222; Domain of unknown function (DUF222)
    cl03075
    Location:99168
    Blast Score: 87
    GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. ...

Alternate Mm_Celera

Genomic

  1. AC_000029.1 

    Range
    17102329..17105251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)