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    Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 [ Mus musculus (house mouse) ]

    Gene ID: 21943, updated on 28-Jun-2015
    Official Symbol
    Tnfsf11provided by MGI
    Official Full Name
    tumor necrosis factor (ligand) superfamily, member 11provided by MGI
    Primary source
    MGI:MGI:1100089
    See related
    Ensembl:ENSMUSG00000022015
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ODF; OPG; OPGL; RANKL; Ly109l; Trance
    Orthologs
    See Tnfsf11 in Epigenomics, MapViewer
    Location:
    14 D3; 14 41.26 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 14 NC_000080.6 (78277446..78308043, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (78677253..78707850, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30608 Neighboring gene microRNA 1971 Neighboring gene predicted gene, 30662 Neighboring gene lactate dehydrogenase A pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
      NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • Osteoblast, organism-specific biosystem (from WikiPathways)
      Osteoblast, organism-specific biosystem
      Osteoblast
    • Osteoclast, organism-specific biosystem (from WikiPathways)
      Osteoclast, organism-specific biosystem
      Osteoclast
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Prolactin signaling pathway, organism-specific biosystem (from KEGG)
      Prolactin signaling pathway, organism-specific biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
    • Prolactin signaling pathway, conserved biosystem (from KEGG)
      Prolactin signaling pathway, conserved biosystemProlactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and meta...
    • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
      Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    • Rheumatoid arthritis, conserved biosystem (from KEGG)
      Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    tumor necrosis factor receptor superfamily binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    TNFSF11-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    activation of JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    bone resorption IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    lymph node development TAS
    Traceable Author Statement
    more info
    PubMed 
    mammary gland alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mammary gland epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
     
    organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    osteoclast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    osteoclast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    paracrine signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of corticotropin-releasing hormone secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of fever generation by positive regulation of prostaglandin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of homotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of osteoclast development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of osteoclast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of osteoclast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tumor necrosis factor-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    tumor necrosis factor ligand superfamily member 11
    Names
    tumor necrosis factor ligand superfamily member 11
    OPG ligand
    TNF-related activation-induced cytokine
    osteoclast differentiation factor
    osteoprotegerin ligand
    receptor activator of NF-kappaB ligand
    receptor activator of nuclear factor kappa B ligand
    receptor activator of nuclear factor kappa-B ligand
    tumor necrosis factor-related activation-induced cytokine

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011613.3NP_035743.2  tumor necrosis factor ligand superfamily member 11

      See identical proteins and their annotated locations for NP_035743.2

      Status: VALIDATED

      Source sequence(s)
      AF019048, AK159498
      Consensus CDS
      CCDS27294.1
      UniProtKB/Swiss-Prot
      O35235
      Related
      ENSMUSP00000022592, ENSMUST00000022592
      Conserved Domains (1) summary
      cd00184
      Location:163310
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p3 C57BL/6J

      Range
      78277446..78308043
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000036.1 Alternate Mm_Celera

      Range
      75790488..75821164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)