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    Il2 interleukin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116562, updated on 26-Apr-2016
    Official Symbol
    Il2provided by RGD
    Official Full Name
    interleukin 2provided by RGD
    Primary source
    RGD:620047
    See related
    Ensembl:ENSRNOG00000017348
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Summary
    cytokine produced by T-cells in response to antigen or mitogen stimulation [RGD, Feb 2006]
    Orthologs
    Location:
    2q25
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (123847150..123851854, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (143460866..143465570, complement)

    Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene similar to 60S ribosomal protein L7 Neighboring gene similar to RIKEN cDNA D630029K19 Neighboring gene THUMP domain-containing protein 1-like Neighboring gene adenosine deaminase domain containing 1 Neighboring gene interleukin 21 Neighboring gene centrin 4

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    carbohydrate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    glycosphingolipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-2 receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    interleukin-2 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    kappa-type opioid receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of B cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of B cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of heart contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of lymphocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of lymphocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of B cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of T cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of activated T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of dendritic spine development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of immunoglobulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of immunoglobulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interferon-gamma production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interferon-gamma production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-17 production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of interleukin-17 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of isotype switching to IgG isotypes IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of isotype switching to IgG isotypes ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of regulatory T cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tyrosine phosphorylation of Stat5 protein IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of tyrosine phosphorylation of Stat5 protein ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase C-activating G-protein coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of T cell homeostatic proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of T cell homeostatic proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    response to ethanol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    interleukin-2
    Names
    IL-2
    T-cell growth factor
    TCGF

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053836.1NP_446288.1  interleukin-2 precursor

      See identical proteins and their annotated locations for NP_446288.1

      Status: PROVISIONAL

      Source sequence(s)
      M22899
      UniProtKB/Swiss-Prot
      P17108
      Related
      ENSRNOP00000023327, ENSRNOT00000023327
      Conserved Domains (1) summary
      smart00189
      Location:1154
      IL2; Interleukin-2 family

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

      Range
      123847150..123851854 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000070.1 Alternate Rn_Celera

      Range
      114959889..114964593 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)