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    PVR poliovirus receptor [ Homo sapiens (human) ]

    Gene ID: 5817, updated on 13-Aug-2016
    Official Symbol
    PVRprovided by HGNC
    Official Full Name
    poliovirus receptorprovided by HGNC
    Primary source
    HGNC:HGNC:9705
    See related
    Ensembl:ENSG00000073008 HPRD:01434; MIM:173850; Vega:OTTHUMG00000151527
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PVS; HVED; CD155; NECL5; TAGE4; Necl-5
    Summary
    The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
    Orthologs
    Location:
    19q13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (44643798..44666161)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45147098..45169429)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene carcinoembryonic antigen related cell adhesion molecule 22, pseudogene Neighboring gene immunoglobulin superfamily member 23 Neighboring gene uncharacterized LOC107985305 Neighboring gene microRNA 4531 Neighboring gene carcinoembryonic antigen related cell adhesion molecule 19 Neighboring gene uncharacterized LOC107985306

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    NHGRI GWA Catalog
    Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef The Nef proteins from HIV-1 M NL4-3, SIVcpz EK505, and SIVgor CP2139 but not from SIVgsn 166, HIV-1 N CK1.62, and P RBF168, are capable of inducing cell surface downregulation of CD155 PubMed
    nef HIV-1 Vpu and Nef are both required to alter the subcellular localization of CD155 in perinuclear compartments and thus interfere with the efficient transport of CD155 to the cell surface PubMed
    nef HIV-1 downregulates PVR on cell surface in a Nef-dependent manner. HIV-1 Vpu contributes to the activity of Nef on surface PVR downregulation PubMed
    nef NK-cell mediated lysis of HIV-1-infected cells via the interaction between DNAM1 and PVR is reduced by HIV-1 Nef PubMed
    Vpr vpr HIV-1 Vpr upregulates PVR expression during HIV-1 infection in CD4+ T-cells PubMed
    vpr HIV-1 Vpr-mediated upregulation of PVR (CD155) requires the interaction of Vpr with the DDB1-Cul4A E3 ligase and induction of ATR-mediated DNA damage repair and G2 arrest PubMed
    Vpu vpu The Vpu proteins from HIV-1 M NL4-3 and SIVgor CP2139 but not from SIVgsn 166, SIVcpz EK505, HIV-1 N CK1.62, and P RBF168, are capable of inducing cell surface downregulation of CD155 PubMed
    vpu HIV-1 Vpu and Nef are both required to alter the subcellular localization of CD155 in perinuclear compartments, and thus interfere with the efficient transport of CD155 to the cell surface PubMed
    vpu The transmembrane domain of HIV-1 Vpu, particularly A10, A14, and A18, is required for cell surface downregulation of CD155, while the CK-2 phosphorylation sites and the second alpha-helix in the cytoplasmic domain are dispensable PubMed
    vpu HIV-1 Vpu contributes to the activity of Nef on surface PVR downregulation PubMed

    Go to the HIV-1, Human Interaction Database

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Adherens junctions interactions, organism-specific biosystem (from REACTOME)
      Adherens junctions interactions, organism-specific biosystemThe adherens junctions (AJ) are multiprotein complexes that promote homotypic cell adhesion in nearly all types of tissue by linking membrane and cytoskeletal components at discrete contact regions (...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell junction organization, organism-specific biosystem (from REACTOME)
      Cell junction organization, organism-specific biosystem
      Cell junction organization
    • Cell-Cell communication, organism-specific biosystem (from REACTOME)
      Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
    • Cell-cell junction organization, organism-specific biosystem (from REACTOME)
      Cell-cell junction organization, organism-specific biosystemEpithelial cell-cell contacts consist of three major adhesion systems: adherens junctions (AJs), tight junctions (TJs), and desmosomes. These adhesion systems differ in their function and compositio...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Nectin adhesion pathway, organism-specific biosystem (from Pathway Interaction Database)
      Nectin adhesion pathway, organism-specific biosystem
      Nectin adhesion pathway
    • Nectin/Necl trans heterodimerization, organism-specific biosystem (from REACTOME)
      Nectin/Necl trans heterodimerization, organism-specific biosystemNectins and Nectin-like molecules (Necls) also undergo trans-heterophilic interactions to interact with other nectin or Necl family members. Besides these trans interactions among nectins and nectin-...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ25946

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space TAS
    Traceable Author Statement
    more info
    PubMed 
    focal adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    poliovirus receptor
    Names
    nectin-like protein 5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008781.2 RefSeqGene

      Range
      5001..27364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001135768.2NP_001129240.1  poliovirus receptor isoform beta precursor

      See identical proteins and their annotated locations for NP_001129240.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (beta) lacks an internal segment including the putative transmembrane domain, compared to isoform alpha, resulting in its secretion into serum and cerebrospinal fluid.
      Source sequence(s)
      AC243964, AK300349, DC400059
      Consensus CDS
      CCDS46105.1
      UniProtKB/Swiss-Prot
      P15151
      Related
      ENSP00000385344, OTTHUMP00000200168, ENST00000403059, OTTHUMT00000323020
      Conserved Domains (3) summary
      cd05718
      Location:43142
      Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
      cd07703
      Location:145240
      Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
      smart00410
      Location:34141
      IG_like; Immunoglobulin like
    2. NM_001135769.2NP_001129241.1  poliovirus receptor isoform gamma precursor

      See identical proteins and their annotated locations for NP_001129241.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (gamma) lacks an internal segment including the putative transmembrane domain, compared to isoform alpha, resulting in its secretion into serum and cerebrospinal fluid.
      Source sequence(s)
      AC243964, AK300349, DC400059
      Consensus CDS
      CCDS46106.1
      UniProtKB/Swiss-Prot
      P15151
      Related
      ENSP00000340870, OTTHUMP00000264489, ENST00000344956, OTTHUMT00000451617
      Conserved Domains (4) summary
      cd05718
      Location:43142
      Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
      cd07703
      Location:145240
      Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
      smart00410
      Location:34141
      IG_like; Immunoglobulin like
      pfam00047
      Location:260314
      ig; Immunoglobulin domain
    3. NM_001135770.3NP_001129242.2  poliovirus receptor isoform delta precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (delta), also known as H20B, has a shorter and distinct C-terminus, compared to isoform alpha.
      Source sequence(s)
      AC243964, DC400059, M24406
      Consensus CDS
      CCDS46107.1
      UniProtKB/Swiss-Prot
      P15151
      UniProtKB/TrEMBL
      A0A0A0MSA9
      Related
      ENSP00000383907, OTTHUMP00000200167, ENST00000406449, OTTHUMT00000323019
      Conserved Domains (3) summary
      cd05718
      Location:43142
      Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
      cd07703
      Location:145240
      Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
      smart00410
      Location:34141
      IG_like; Immunoglobulin like
    4. NM_006505.4NP_006496.4  poliovirus receptor isoform alpha precursor

      See identical proteins and their annotated locations for NP_006496.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (alpha), also known as H20A.
      Source sequence(s)
      AC243964, AK290946, AK300349, DC400059
      Consensus CDS
      CCDS12640.1
      UniProtKB/Swiss-Prot
      P15151
      UniProtKB/TrEMBL
      A0A0C4DG49, A8K4I1
      Related
      ENSP00000402060, OTTHUMP00000200165, ENST00000425690, OTTHUMT00000323017
      Conserved Domains (4) summary
      cd05718
      Location:43142
      Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
      cd07703
      Location:145240
      Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
      smart00410
      Location:34141
      IG_like; Immunoglobulin like
      pfam00047
      Location:260314
      ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      44643798..44666161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      45149748..45172111
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)