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    Ikbkb inhibitor of kappaB kinase beta [ Mus musculus (house mouse) ]

    Gene ID: 16150, updated on 23-Apr-2016
    Official Symbol
    Ikbkbprovided by MGI
    Official Full Name
    inhibitor of kappaB kinase betaprovided by MGI
    Primary source
    MGI:MGI:1338071
    See related
    Ensembl:ENSMUSG00000031537 Vega:OTTMUSG00000020581
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IKK2; IKK-2; IKK[b]; IKKbeta; AI132552; IKK-beta
    Orthologs
    Location:
    8; 8 A3-A4
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 8 NC_000074.6 (22659205..22706585, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (23769677..23817055, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930013F10 gene Neighboring gene dickkopf WNT signaling pathway inhibitor 4 Neighboring gene polymerase (DNA directed), beta Neighboring gene predicted gene 15346 Neighboring gene plasminogen activator, tissue Neighboring gene adaptor-related protein complex 3, mu 2 subunit

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (11)  1 citation
    • Chemically induced (ENU) (1) 
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    • Acute myeloid leukemia, organism-specific biosystem (from KEGG)
      Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
    • Acute myeloid leukemia, conserved biosystem (from KEGG)
      Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
    • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
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    • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
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    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Apoptosis, conserved biosystem (from KEGG)
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    • Apoptosis signaling pathway, organism-specific biosystem (from LIPID MAPS)
      Apoptosis signaling pathway, organism-specific biosystem
      Apoptosis signaling pathway
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ???? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation...
    • B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
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    • B cell receptor signaling pathway, conserved biosystem (from KEGG)
      B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
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    • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
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    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
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    • Chemokine signaling pathway, organism-specific biosystem (from WikiPathways)
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    • Chemokine signaling pathway, conserved biosystem (from KEGG)
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    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Cytosolic DNA-sensing pathway, organism-specific biosystem (from KEGG)
      Cytosolic DNA-sensing pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
    • Cytosolic DNA-sensing pathway, conserved biosystem (from KEGG)
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    • EBV LMP1 signaling, organism-specific biosystem (from WikiPathways)
      EBV LMP1 signaling, organism-specific biosystembased on science-slides...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • FoxO signaling pathway, organism-specific biosystem (from KEGG)
      FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hepatitis B, organism-specific biosystem (from KEGG)
      Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
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    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
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    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystem
      Insulin Signaling
    • Insulin resistance, organism-specific biosystem (from KEGG)
      Insulin resistance, organism-specific biosystemInsulin resistance is a condition where cells become resistant to the effects of insulin. It is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alcoholic...
    • Insulin signaling pathway, organism-specific biosystem (from KEGG)
      Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin signaling pathway, conserved biosystem (from KEGG)
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    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
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    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
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    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
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    • MicroRNAs in cancer, conserved biosystem (from KEGG)
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    • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
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    • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
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    • NLR proteins, organism-specific biosystem (from WikiPathways)
      NLR proteins, organism-specific biosystemMammalian cells have evolved a set of specialized pattern recognition-molecules (PRMs) to detect conserved molecular motifs present on pathogens known as pathogen-associated-molecular- patterns (PAMP...
    • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
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    • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
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    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
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    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
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    • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
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    • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
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    • Osteoclast differentiation, conserved biosystem (from KEGG)
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    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
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    • PI3K/Akt/mTOR signaling pathway, organism-specific biosystem (from LIPID MAPS)
      PI3K/Akt/mTOR signaling pathway, organism-specific biosystem
      PI3K/Akt/mTOR signaling pathway
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
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    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
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    • Prostate cancer, organism-specific biosystem (from KEGG)
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    • Prostate cancer, conserved biosystem (from KEGG)
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    • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
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    • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
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    • Ras signaling pathway, organism-specific biosystem (from KEGG)
      Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
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    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
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    • TLR4 (Toll-like receptor 4) signaling pathway, organism-specific biosystem (from LIPID MAPS)
      TLR4 (Toll-like receptor 4) signaling pathway, organism-specific biosystem
      TLR4 (Toll-like receptor 4) signaling pathway
    • TNF signaling pathway, organism-specific biosystem (from KEGG)
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    • TNF signaling pathway, conserved biosystem (from KEGG)
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    • TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem
      TNF-alpha NF-kB Signaling Pathway
    • Toll Like Receptor signaling, organism-specific biosystem (from WikiPathways)
      Toll Like Receptor signaling, organism-specific biosystem
      Toll Like Receptor signaling
    • Toll-like receptor signaling, organism-specific biosystem (from KEGG)
      Toll-like receptor signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
    • Toll-like receptor signaling, conserved biosystem (from KEGG)
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    • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
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    • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
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    • Toxoplasmosis, organism-specific biosystem (from KEGG)
      Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
    • Toxoplasmosis, conserved biosystem (from KEGG)
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    • Type II diabetes mellitus, organism-specific biosystem (from KEGG)
      Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • Type II diabetes mellitus, conserved biosystem (from KEGG)
      Type II diabetes mellitus, conserved biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • estrogen signalling, organism-specific biosystem (from WikiPathways)
      estrogen signalling, organism-specific biosystemEstrogen receptor refers to a group of receptors which are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear h...
    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystem
      mTOR signaling pathway
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystem
      mTOR signaling pathway
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    IkappaB kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor signaling protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    B cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    I-kappaB kinase/NF-kappaB signaling ISO
    Inferred from Sequence Orthology
    more info
     
    I-kappaB phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    cortical actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of bicellular tight junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of myosin-light-chain-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cation channel activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sodium ion transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    serine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    tumor necrosis factor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    CD40 receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    IkappaB kinase complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    inhibitor of nuclear factor kappa-B kinase subunit beta
    Names
    I-kappa-B kinase 2
    I-kappa-B-kinase beta
    IKK-B
    NFKBIKB
    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
    nuclear factor NF-kappa-B inhibitor kinase beta
    NP_001153246.1
    NP_034676.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159774.1NP_001153246.1  inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1

      See identical proteins and their annotated locations for NP_001153246.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AA203913, AK144603, BY015258
      Consensus CDS
      CCDS52522.1
      UniProtKB/TrEMBL
      Q5D0E0
      Related
      ENSMUSP00000033939, OTTMUSP00000022455, ENSMUST00000033939, OTTMUST00000048766
      Conserved Domains (3) summary
      pfam12179
      Location:705742
      IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain
      smart00220
      Location:15290
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14038
      Location:20309
      STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta
    2. NM_010546.2NP_034676.1  inhibitor of nuclear factor kappa-B kinase subunit beta isoform 2

      See identical proteins and their annotated locations for NP_034676.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) retains sequence in the 3' coding region, which results in an early stop codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AA203913, AF088910, AK144603, BY015258
      Consensus CDS
      CCDS22182.1
      UniProtKB/Swiss-Prot
      O88351
      UniProtKB/TrEMBL
      A0A0R4J0T4, Q5D0E0
      Related
      ENSMUSP00000064235, OTTMUSP00000022456, ENSMUST00000063401, OTTMUST00000048776
      Conserved Domains (2) summary
      smart00220
      Location:15290
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14038
      Location:20309
      STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p3 C57BL/6J

      Range
      22659205..22706585 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509019.2XP_006509082.1  

      Conserved Domains (3) summary
      pfam12179
      Location:705737
      IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain
      smart00220
      Location:15290
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14038
      Location:20309
      STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta
    2. XM_006509020.2XP_006509083.1  

      Conserved Domains (2) summary
      smart00220
      Location:15290
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14038
      Location:20309
      STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta
    3. XM_006509021.1XP_006509084.1  

      Conserved Domains (2) summary
      smart00220
      Location:15290
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14038
      Location:20309
      STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta
    4. XM_006509022.2XP_006509085.1  

      Conserved Domains (2) summary
      smart00220
      Location:15290
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14038
      Location:20309
      STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta
    5. XM_006509023.2XP_006509086.1  

      Related
      ENSMUSP00000138378, OTTMUSP00000065163, ENSMUST00000135326, OTTMUST00000048768
      Conserved Domains (2) summary
      smart00220
      Location:15290
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14038
      Location:20309
      STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta

    RNA

    1. XR_870200.1 RNA Sequence

      Related
      ENSMUST00000125314, OTTMUST00000048767

    Alternate Mm_Celera

    Genomic

    1. AC_000030.1 Alternate Mm_Celera

      Range
      24149472..24196863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)