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PI4KA phosphatidylinositol 4-kinase, catalytic, alpha [ Homo sapiens (human) ]

Gene ID: 5297, updated on 11-Sep-2014
Official Symbol
PI4KAprovided by HGNC
Official Full Name
phosphatidylinositol 4-kinase, catalytic, alphaprovided by HGNC
Primary source
HGNC:HGNC:8983
See related
Ensembl:ENSG00000241973; HPRD:08972; MIM:600286; Vega:OTTHUMG00000167440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIK4CA; pi4K230; PI4K-ALPHA
Summary
This gene encodes a phosphatidylinositol (PI) 4-kinase which catalyzes the first committed step in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and adenosine. The protein encoded by this gene is a type III enzyme that is not inhibited by adenosine. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
See PI4KA in Epigenomics, MapViewer
Location:
22q11.21
Exon count:
55
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 22 NC_000022.11 (20707691..20858812, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (21061979..21213100, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101060025 Neighboring gene transmembrane protein 191A (pseudogene) Neighboring gene breakpoint cluster region pseudogene 5 Neighboring gene serpin peptidase inhibitor, clade D (heparin cofactor), member 1 Neighboring gene synaptosomal-associated protein, 29kDa Neighboring gene v-crk avian sarcoma virus CT10 oncogene homolog-like Neighboring gene uncharacterized LOC101928891

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of phosphatidylinositol 4-kinase, catalytic, alpha (PI4KA) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ16556

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylinositol phosphorylation IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
phospholipid metabolic process TAS
Traceable Author Statement
more info
 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi-associated vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
phosphatidylinositol 4-kinase alpha
Names
phosphatidylinositol 4-kinase alpha
PI4-kinase alpha
ptdIns-4-kinase alpha
phosphatidylinositol 4-kinase 230
phosphatidylinositol 4-kinase, type III, alpha
NP_002641.1
NP_477352.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033052.1 

    Range
    5001..156122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002650.2NP_002641.1  phosphatidylinositol 4-kinase alpha isoform 2

    See proteins identical to NP_002641.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and CDS compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    BC053654, BU685224, L36151
    UniProtKB/Swiss-Prot
    P42356
    Conserved Domains (2) summary
    cd05167
    Location:527853
    PI4Kc_III_alpha; Phosphoinositide 4-kinase (PI4K), Type III, alpha isoform, catalytic domain; The PI4K catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein ...
    cd00871
    Location:299474
    PI4Ka; Phosphoinositide 4-kinase(PI4K), accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. PI4K phosphorylates hydroxylgroup at position 4 on the ...
  2. NM_058004.3NP_477352.3  phosphatidylinositol 4-kinase alpha isoform 1

    See proteins identical to NP_477352.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB210002, AK302424, AL048955, BU685224, DA959365
    Consensus CDS
    CCDS33603.2
    UniProtKB/TrEMBL
    B4DYG5
    UniProtKB/TrEMBL
    J3KN10
    UniProtKB/TrEMBL
    Q4LE69
    Related
    ENSP00000255882, OTTHUMP00000028907, ENST00000255882, OTTHUMT00000075723
    Conserved Domains (2) summary
    cd05167
    Location:17752101
    PI4Kc_III_alpha; Phosphoinositide 4-kinase (PI4K), Type III, alpha isoform, catalytic domain; The PI4K catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein ...
    cd00871
    Location:15471722
    PI4Ka; Phosphoinositide 4-kinase(PI4K), accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. PI4K phosphorylates hydroxylgroup at position 4 on the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000022.11 

    Range
    20707691..20858812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261634.1XP_005261691.1  

    Conserved Domains (2) summary
    cd05167
    Location:17722098
    PI4Kc_III_alpha; Phosphoinositide 4-kinase (PI4K), Type III, alpha isoform, catalytic domain; The PI4K catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein ...
    cd00871
    Location:15441719
    PI4Ka; Phosphoinositide 4-kinase(PI4K), accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. PI4K phosphorylates hydroxylgroup at position 4 on the ...
  2. XM_005261635.1XP_005261692.1  

    Conserved Domains (1) summary
    cd05167
    Location:15271853
    PI4Kc_III_alpha; Phosphoinositide 4-kinase (PI4K), Type III, alpha isoform, catalytic domain; The PI4K catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein ...

Alternate HuRef

Genomic

  1. AC_000154.1 

    Range
    4329838..4481241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018933.2 

    Range
    21062151..21213286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)