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Mybpc3 myosin binding protein C, cardiac [ Mus musculus (house mouse) ]

Gene ID: 17868, updated on 19-Jul-2014
Official Symbol
Mybpc3provided by MGI
Official Full Name
myosin binding protein C, cardiacprovided by MGI
Primary source
MGI:102844
Locus tag
RP23-20F9.3
See related
Ensembl:ENSMUSG00000002100; Vega:OTTMUSG00000014369
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
See Mybpc3 in Epigenomics, MapViewer
Location:
2 E1; 2
Exon count:
35
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 2 NC_000068.7 (91118114..91136518)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100862024 Neighboring gene spleen focus forming virus (SFFV) proviral integration oncogene Neighboring gene MAP-kinase activating death domain Neighboring gene nuclear receptor subfamily 1, group H, member 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • , (from )
    ,
  • , (from )
    ,
  • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
    Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Dilated cardiomyopathy, conserved biosystem (from KEGG)
    Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Striated Muscle Contraction, organism-specific biosystem (from WikiPathways)
    Striated Muscle Contraction, organism-specific biosystem
    Striated Muscle Contraction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
myosin binding ISO
Inferred from Sequence Orthology
more info
 
myosin heavy chain binding IPI
Inferred from Physical Interaction
more info
PubMed 
myosin heavy chain binding ISO
Inferred from Sequence Orthology
more info
 
structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
structural constituent of muscle ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
myosin filament assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
sarcomere organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
ventricular cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
A band IDA
Inferred from Direct Assay
more info
PubMed 
A band ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
myofibril IDA
Inferred from Direct Assay
more info
PubMed 
myosin filament IEA
Inferred from Electronic Annotation
more info
 
sarcomere IDA
Inferred from Direct Assay
more info
PubMed 
sarcomere ISO
Inferred from Sequence Orthology
more info
 
striated muscle myosin thick filament ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
myosin-binding protein C, cardiac-type
Names
myosin-binding protein C, cardiac-type
cardiac MyBP-C
cardiac C-protein
C-protein, cardiac muscle isoform

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008653.2NP_032679.2  myosin-binding protein C, cardiac-type

    See proteins identical to NP_032679.2

    Status: VALIDATED

    Source sequence(s)
    AK146886
    Consensus CDS
    CCDS50631.1
    UniProtKB/TrEMBL
    Q3UIK0
    Related
    ENSMUSP00000127070, OTTMUSP00000015227, ENSMUST00000169776, OTTMUST00000033992
    Conserved Domains (7) summary
    cd00096
    Location:12021269
    Blast Score: 140
    Ig; Immunoglobulin domain
    cd05748
    Location:9941066
    Blast Score: 211
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    cd05894
    Location:660772
    Blast Score: 358
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:9851066
    Blast Score: 140
    IG_like; Immunoglobulin like
    cd00063
    Location:776866
    Blast Score: 209
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:11851274
    Blast Score: 233
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:567633
    Blast Score: 100
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000068.7 

    Range
    91118114..91136518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498880.1XP_006498943.1  

    See proteins identical to XP_006498943.1

    Conserved Domains (7) summary
    cd00096
    Location:12141281
    Blast Score: 140
    Ig; Immunoglobulin domain
    cd05748
    Location:9941066
    Blast Score: 211
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    cd05894
    Location:660772
    Blast Score: 358
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:9851066
    Blast Score: 140
    IG_like; Immunoglobulin like
    cd00063
    Location:776866
    Blast Score: 209
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:11971286
    Blast Score: 233
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:567633
    Blast Score: 100
    Ig; Immunoglobulin domain
  2. XM_006498879.1XP_006498942.1  

    See proteins identical to XP_006498942.1

    Conserved Domains (7) summary
    cd00096
    Location:12141281
    Blast Score: 140
    Ig; Immunoglobulin domain
    cd05748
    Location:9941066
    Blast Score: 211
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    cd05894
    Location:660772
    Blast Score: 358
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:9851066
    Blast Score: 140
    IG_like; Immunoglobulin like
    cd00063
    Location:776866
    Blast Score: 209
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:11971286
    Blast Score: 233
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:567633
    Blast Score: 100
    Ig; Immunoglobulin domain
  3. XM_006498881.1XP_006498944.1  

    Conserved Domains (7) summary
    cd00096
    Location:12131280
    Blast Score: 140
    Ig; Immunoglobulin domain
    cd05748
    Location:9931065
    Blast Score: 211
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    cd05894
    Location:659771
    Blast Score: 358
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:9841065
    Blast Score: 140
    IG_like; Immunoglobulin like
    cd00063
    Location:775865
    Blast Score: 208
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:11961285
    Blast Score: 233
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:566632
    Blast Score: 99
    Ig; Immunoglobulin domain
  4. XM_006498882.1XP_006498945.1  

    Related
    ENSMUSP00000119994, OTTMUSP00000042060, ENSMUST00000137942, OTTMUST00000034060
    Conserved Domains (7) summary
    cd00096
    Location:12011268
    Blast Score: 140
    Ig; Immunoglobulin domain
    cd05748
    Location:9931065
    Blast Score: 211
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    cd05894
    Location:659771
    Blast Score: 358
    Ig_C5_MyBP-C; C5 immunoglobulin (Ig) domain of cardiac myosin binding protein C (MyBP-C)
    smart00410
    Location:9841065
    Blast Score: 140
    IG_like; Immunoglobulin like
    cd00063
    Location:775865
    Blast Score: 208
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:11841273
    Blast Score: 233
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:566632
    Blast Score: 100
    Ig; Immunoglobulin domain

Alternate Mm_Celera

Genomic

  1. AC_000024.1 

    Range
    92502890..92521291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)