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    PLIN2 perilipin 2 [ Homo sapiens (human) ]

    Gene ID: 123, updated on 24-Aug-2015
    Official Symbol
    PLIN2provided by HGNC
    Official Full Name
    perilipin 2provided by HGNC
    Primary source
    HGNC:HGNC:248
    See related
    Ensembl:ENSG00000147872; HPRD:00057; MIM:103195; Vega:OTTHUMG00000019624
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADFP; ADRP
    Summary
    The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]
    Orthologs
    See PLIN2 in Epigenomics, MapViewer
    Location:
    9p22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (19108388..19127606, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (19115759..19127604, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene Ras-related GTP binding A Neighboring gene HAUS augmin-like complex, subunit 6 Neighboring gene small Cajal body-specific RNA 8 Neighboring gene ribosomal protein S6 pseudogene 10 Neighboring gene DENN/MADD domain containing 4C

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of perilipin 2 (PLIN2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC10598

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    cellular lipid metabolic process TAS
    Traceable Author Statement
    more info
     
    lipid storage IEA
    Inferred from Electronic Annotation
    more info
     
    long-chain fatty acid transport IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    lipid particle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    perilipin-2
    Names
    adipophilin
    adipose differentiation-related protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122.3NP_001113.2  perilipin-2

      See identical proteins and their annotated locations for NP_001113.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      BC005127, BI494696, CN277218
      Consensus CDS
      CCDS6490.1
      UniProtKB/TrEMBL
      Q6FHZ7
      UniProtKB/Swiss-Prot
      Q99541
      Related
      ENSP00000276914, OTTHUMP00000021107, ENST00000276914, OTTHUMT00000051835
      Conserved Domains (1) summary
      pfam03036
      Location:2396
      Perilipin; Perilipin family

    RNA

    1. NR_038064.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is alternatively spliced in the 5' region compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon (with a strong Kozak signal) as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC005127, BI494696, CN277218

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

      Range
      19108388..19127606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006716719.1XP_006716782.1  

      Conserved Domains (1) summary
      pfam03036
      Location:2396
      Perilipin; Perilipin family

    Alternate CHM1_1.1

    Genomic

    1. NC_018920.2 Alternate CHM1_1.1

      Range
      19115770..19127537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)