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    Ghr growth hormone receptor [ Mus musculus (house mouse) ]

    Gene ID: 14600, updated on 7-Apr-2016
    Official Symbol
    Ghrprovided by MGI
    Official Full Name
    growth hormone receptorprovided by MGI
    Primary source
    MGI:MGI:95708
    See related
    Ensembl:ENSMUSG00000055737 Vega:OTTMUSG00000030599
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GHBP; GHR/BP
    Orthologs
    Location:
    15 A1; 15 1.84 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 15 NC_000081.6 (3317755..3583527, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (3267760..3533230, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30057 Neighboring gene coiled-coil domain containing 152 Neighboring gene selenoprotein P, plasma, 1 Neighboring gene predicted gene, 41254 Neighboring gene predicted gene, 41255 Neighboring gene mediator complex subunit 27 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (10)  1 citation
    • Chemically induced (ENU) (1) 

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth hormone receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptide hormone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    peptide hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    2-oxoglutarate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    activation of JAK2 kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of Janus kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
     
    allantoin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    citrate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    creatine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    creatinine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    growth hormone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth hormone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    hormone-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    insulin-like growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    isoleucine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    oxaloacetate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of multicellular organism growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to estradiol ISO
    Inferred from Sequence Orthology
    more info
     
    succinate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    taurine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    valine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth hormone receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    growth hormone receptor
    Names
    GH receptor
    Growth hormone receptor precursor (GH receptor) (GH binding protein) (GHBP) (Serum binding protein)
    growth hormone receptor/binding protein
    somatotropin receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048178.2NP_001041643.1  growth hormone receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001041643.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and uses an alternate 3'-terminal exon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC113323, AC121307, AK143925, AK148440
      Consensus CDS
      CCDS37024.1
      UniProtKB/Swiss-Prot
      P16882
      UniProtKB/TrEMBL
      Q3UNY8
      Related
      ENSMUSP00000106326, OTTMUSP00000039788, ENSMUST00000110698, OTTMUST00000075776
      Conserved Domains (2) summary
      cd00063
      Location:157258
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl21522
      Location:49135
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    2. NM_001286370.1NP_001273299.1  growth hormone receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_001273299.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Both variants 1 and 4 encode the same isoform (1).
      Source sequence(s)
      AC166491, AK143886
      Consensus CDS
      CCDS27358.1
      UniProtKB/Swiss-Prot
      P16882
      UniProtKB/TrEMBL
      Q3UP14
      Related
      ENSMUSP00000124064, OTTMUSP00000039787, ENSMUST00000161561, OTTMUST00000075775
      Conserved Domains (3) summary
      cd00063
      Location:157258
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12772
      Location:325634
      GHBP; Growth hormone receptor binding
      cl21522
      Location:49135
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    3. NM_010284.3NP_034414.2  growth hormone receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_034414.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 4 encode the same isoform.
      Source sequence(s)
      AC113323, AC166491, AK143925, AK148440
      Consensus CDS
      CCDS27358.1
      UniProtKB/Swiss-Prot
      P16882
      UniProtKB/TrEMBL
      Q3UNY8, Q3UP14
      Related
      ENSMUSP00000069457, OTTMUSP00000039789, ENSMUST00000069451, OTTMUST00000075779
      Conserved Domains (3) summary
      cd00063
      Location:157258
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12772
      Location:325634
      GHBP; Growth hormone receptor binding
      cl21522
      Location:49135
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p3 C57BL/6J

      Range
      3317755..3583527 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519963.2XP_006520026.1  

      See identical proteins and their annotated locations for XP_006520026.1

      UniProtKB/Swiss-Prot
      P16882
      UniProtKB/TrEMBL
      Q3UP14
      Conserved Domains (3) summary
      cd00063
      Location:157258
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12772
      Location:325634
      GHBP; Growth hormone receptor binding
      cl21522
      Location:49135
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    2. XM_006519965.2XP_006520028.1  

      See identical proteins and their annotated locations for XP_006520028.1

      UniProtKB/Swiss-Prot
      P16882
      UniProtKB/TrEMBL
      Q3UP14
      Conserved Domains (3) summary
      cd00063
      Location:157258
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam12772
      Location:325634
      GHBP; Growth hormone receptor binding
      cl21522
      Location:49135
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    Alternate Mm_Celera

    Genomic

    1. AC_000037.1 Alternate Mm_Celera

      Range
      3182316..3449004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001048147.1: Suppressed sequence

      Description
      NM_001048147.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.