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TCF4 transcription factor 4 [ Homo sapiens (human) ]

Gene ID: 6925, updated on 11-Sep-2014
Official Symbol
TCF4provided by HGNC
Official Full Name
transcription factor 4provided by HGNC
Primary source
HGNC:HGNC:11634
See related
Ensembl:ENSG00000196628; HPRD:03780; MIM:602272; Vega:OTTHUMG00000132713
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E2-2; ITF2; PTHS; SEF2; ITF-2; SEF-2; TCF-4; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; bHLHb19
Summary
This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Aug 2011]
Annotation information
Note: TCF4 (GeneID: 6925) and TCF7L2 (GeneID: 6934) loci share the TCF4 symbol/alias in common. TCF4 is a widely used alternative name for T-cell-specific transcription factor 4 (TCF7L2) conflicting with the official symbol for transcription factor 4 (TCF4). [26 Jun 2008]
See TCF4 in Epigenomics, MapViewer
Location:
18q21.1
Exon count:
33
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 18 NC_000018.10 (55222331..55635957, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (52889562..53303252, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927229 Neighboring gene RNA, 5S ribosomal pseudogene 459 Neighboring gene microRNA 4529 Neighboring gene ribosomal protein L21 pseudogene 126 Neighboring gene uncharacterized LOC101927273 Neighboring gene uncharacterized LOC642484 Neighboring gene uncharacterized LOC102724698

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Pitt-Hopkins syndrome
MedGen: C1970431 OMIM: 610954 GeneReviews: Pitt-Hopkins Syndrome
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2012-02-09)

ISCA Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated (2012-02-09)

ISCA Genome Curation PagePubMed

NHGRI GWAS Catalog

Description
A comprehensive family-based replication study of schizophrenia genes.
NHGRI GWA Catalog
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.
NHGRI GWA Catalog
Common variants conferring risk of schizophrenia.
NHGRI GWA Catalog
E2-2 protein and Fuchs's corneal dystrophy.
NHGRI GWA Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
NHGRI GWA Catalog
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4.
NHGRI GWA Catalog
Genome-wide association study identifies five new schizophrenia loci.
NHGRI GWA Catalog
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
NHGRI GWA Catalog
Genome-wide meta-analysis for severe diabetic retinopathy.
NHGRI GWA Catalog
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
NHGRI GWA Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of Beta-catenin (CTNNB1) and transcription factor 4 (TCF4) by siRNA enhances HIV-1 transcription in astrocytes PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat TCF4 and beta-catenin proteins inhibit docking of HIV-1 Tat at the TAR region of the HIV-1 LTR PubMed
tat Axin1 regulates HIV-1 Tat-mediated transcription, which requires beta-catenin and TCF4 PubMed

Go to the HIV-1, Human Protein Interaction Database

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  • Coregulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
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    Coregulation of Androgen receptor activity
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC149723, MGC149724

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
E-box binding ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
TFIIB-class binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
TFIIB-class transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein heterodimerization activity NAS
Non-traceable Author Statement
more info
PubMed 
sequence-specific DNA binding RNA polymerase recruiting transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA-templated transcription, initiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
protein-DNA complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
transcription initiation from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Preferred Names
transcription factor 4
Names
transcription factor 4
SL3-3 enhancer factor 2
transcription factor 4, isoform C
transcription factor 4, isoform D
transcription factor 4, isoform E
transcription factor 4, isoform R
immunoglobulin transcription factor 2
class B basic helix-loop-helix protein 19

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011716.1 

    Range
    1820..371299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001083962.1NP_001077431.1  transcription factor 4 isoform a

    See proteins identical to NP_001077431.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (a, also known as TCF4-B+) is shorter at the N-terminus compared to isoform c.
    Source sequence(s)
    AC091103, AK122765, BC125084, BJ989626
    Consensus CDS
    CCDS42438.1
    UniProtKB/TrEMBL
    B3KVA4
    UniProtKB/Swiss-Prot
    P15884
    Related
    ENSP00000346440, ENST00000354452
    Conserved Domains (1) summary
    cd00083
    Location:566626
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  2. NM_001243226.2NP_001230155.2  transcription factor 4 isoform c

    See proteins identical to NP_001230155.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (c).
    Source sequence(s)
    AC091103, AK315074, BC031056, BC125085, HY051304
    Consensus CDS
    CCDS58631.1
    UniProtKB/Swiss-Prot
    P15884
    Conserved Domains (1) summary
    cd00083
    Location:668728
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  3. NM_001243227.1NP_001230156.1  transcription factor 4 isoform d

    See proteins identical to NP_001230156.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (d) is shorter at the N-terminus compared to isoform c.
    Source sequence(s)
    AC091103, AK299169
    Consensus CDS
    CCDS58629.1
    UniProtKB/Swiss-Prot
    P15884
    Conserved Domains (1) summary
    cd00083
    Location:542602
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  4. NM_001243228.1NP_001230157.1  transcription factor 4 isoform e

    See proteins identical to NP_001230157.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice site at the 5' end of an exon compared to variant 3. The resulting isoform (e) is shorter at the N-terminus and contains an alternate internal segment compared to isoform c.
    Source sequence(s)
    AC091103, AK299169, AK315074
    Consensus CDS
    CCDS58630.1
    UniProtKB/TrEMBL
    H3BTP3
    UniProtKB/Swiss-Prot
    P15884
    Conserved Domains (1) summary
    cd00083
    Location:572632
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  5. NM_001243230.1NP_001230159.1  transcription factor 4 isoform f

    See proteins identical to NP_001230159.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice site at the 3' end of an exon compared to variant 3. The resulting isoform (f, also known as TCF4-E-) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform c.
    Source sequence(s)
    AC091103, AK122765, FR748216
    Consensus CDS
    CCDS59321.1
    UniProtKB/TrEMBL
    B3KVA4
    UniProtKB/Swiss-Prot
    P15884
    Conserved Domains (1) summary
    cd00083
    Location:559619
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  6. NM_001243231.1NP_001230160.1  transcription factor 4 isoform g

    See proteins identical to NP_001230160.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice site at the 3' end of an exon compared to variant 3. The resulting isoform (g) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform c.
    Source sequence(s)
    AC091103, AK096862
    Consensus CDS
    CCDS58628.1
    UniProtKB/Swiss-Prot
    P15884
    Conserved Domains (1) summary
    cd00083
    Location:520580
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  7. NM_001243232.1NP_001230161.1  transcription factor 4 isoform h

    See proteins identical to NP_001230161.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice site at the 5' end of an exon compared to variant 3. The resulting isoform (h) has a shorter and distinct N-terminus and contains an alternate internal segment compared to isoform c.
    Source sequence(s)
    AC091103, AK095041
    Consensus CDS
    CCDS58627.1
    UniProtKB/Swiss-Prot
    P15884
    Conserved Domains (1) summary
    cd00083
    Location:495555
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  8. NM_001243233.1NP_001230162.1  transcription factor 4 isoform i

    See proteins identical to NP_001230162.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice site at the 3' end of an exon compared to variant 3. The resulting isoform (i) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform c.
    Source sequence(s)
    AC091103, AK300612
    Consensus CDS
    CCDS58626.1
    UniProtKB/Swiss-Prot
    P15884
    Conserved Domains (1) summary
    cd00083
    Location:432492
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  9. NM_001243234.1NP_001230163.1  transcription factor 4 isoform j

    See proteins identical to NP_001230163.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (j, also known as TCF4-A+) has a shorter and distinct N-terminus compared to isoform c.
    Source sequence(s)
    AC091103, AK300038, DC298029, FR748220
    Consensus CDS
    CCDS58624.1
    UniProtKB/Swiss-Prot
    P15884
    Conserved Domains (1) summary
    cd00083
    Location:406466
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  10. NM_001243235.1NP_001230164.1  transcription factor 4 isoform k

    See proteins identical to NP_001230164.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice site at the 3' end of an exon compared to variant 3. The resulting isoform (k, also known as TCF4-A-) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform c.
    Source sequence(s)
    AC091103, AK300038, DC298029, FR748221
    Consensus CDS
    CCDS58625.1
    UniProtKB/Swiss-Prot
    P15884
    Conserved Domains (1) summary
    cd00083
    Location:402462
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  11. NM_001243236.1NP_001230165.1  transcription factor 4 isoform l

    See proteins identical to NP_001230165.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice site at the 3' end of an exon compared to variant 3. The resulting isoform (l) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform c.
    Source sequence(s)
    AC091103, AK300038, AL518903, FR748222
    Consensus CDS
    CCDS58623.1
    UniProtKB/Swiss-Prot
    P15884
    Conserved Domains (1) summary
    cd00083
    Location:402462
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  12. NM_003199.2NP_003190.1  transcription factor 4 isoform b

    See proteins identical to NP_003190.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice site at the 3' end of an exon compared to variant 3. The resulting isoform (b, also known as TCF4-B-) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform c.
    Source sequence(s)
    AC091103, AK122765, BJ989626, M74719
    Consensus CDS
    CCDS11960.1
    UniProtKB/TrEMBL
    A0A024R2C0
    UniProtKB/TrEMBL
    B3KVA4
    UniProtKB/Swiss-Prot
    P15884
    Related
    ENSP00000348374, OTTHUMP00000163568, ENST00000356073, OTTHUMT00000256014
    Conserved Domains (1) summary
    cd00083
    Location:562622
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000018.10 

    Range
    55222331..55635957
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722534.1XP_006722597.1  

    Conserved Domains (2) summary
    cd00083
    Location:609669
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam13900
    Location:627
    Blast Score: 122
    GVQW; Putative binding domain
  2. XM_006722533.1XP_006722596.1  

    Conserved Domains (2) summary
    cd00083
    Location:613673
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam13900
    Location:627
    Blast Score: 122
    GVQW; Putative binding domain
  3. XM_006722536.1XP_006722599.1  

    See proteins identical to XP_006722599.1

    UniProtKB/Swiss-Prot
    P15884
    Conserved Domains (1) summary
    cd00083
    Location:566626
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  4. XM_006722537.1XP_006722600.1  

    See proteins identical to XP_006722600.1

    UniProtKB/Swiss-Prot
    P15884
    Conserved Domains (1) summary
    cd00083
    Location:566626
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  5. XM_006722535.1XP_006722598.1  

    Conserved Domains (1) summary
    cd00083
    Location:604664
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  6. XM_006722532.1XP_006722595.1  

    Conserved Domains (1) summary
    cd00083
    Location:651711
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  7. XM_006722530.1XP_006722593.1  

    Conserved Domains (1) summary
    cd00083
    Location:655715
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  8. XM_006722531.1XP_006722594.1  

    Conserved Domains (1) summary
    cd00083
    Location:652712
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  9. XM_005266739.2XP_005266796.1  

    See proteins identical to XP_005266796.1

    Conserved Domains (1) summary
    cd00083
    Location:656716
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  10. XM_006722529.1XP_006722592.1  

    See proteins identical to XP_006722592.1

    Conserved Domains (1) summary
    cd00083
    Location:656716
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  11. XM_005266741.2XP_005266798.1  

    Conserved Domains (1) summary
    cd00083
    Location:565625
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  12. XM_005266743.2XP_005266800.1  

    See proteins identical to XP_005266800.1

    UniProtKB/Swiss-Prot
    P15884
    Conserved Domains (1) summary
    cd00083
    Location:542602
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  13. XM_005266745.2XP_005266802.1  

    See proteins identical to XP_005266802.1

    Conserved Domains (1) summary
    cd00083
    Location:541601
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  14. XM_005266746.2XP_005266803.1  

    See proteins identical to XP_005266803.1

    UniProtKB/Swiss-Prot
    P15884
    Conserved Domains (1) summary
    cd00083
    Location:538598
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  15. XM_006722538.1XP_006722601.1  

    See proteins identical to XP_006722601.1

    Conserved Domains (1) summary
    cd00083
    Location:541601
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  16. XM_005266744.2XP_005266801.1  

    See proteins identical to XP_005266801.1

    UniProtKB/Swiss-Prot
    P15884
    Conserved Domains (1) summary
    cd00083
    Location:542602
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  17. XM_005266747.2XP_005266804.1  

    Conserved Domains (1) summary
    cd00083
    Location:524584
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  18. XM_005266752.2XP_005266809.1  

    See proteins identical to XP_005266809.1

    Conserved Domains (1) summary
    cd00083
    Location:436496
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  19. XM_005266755.2XP_005266812.1  

    See proteins identical to XP_005266812.1

    Conserved Domains (1) summary
    cd00083
    Location:436496
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  20. XM_005266750.2XP_005266807.1  

    See proteins identical to XP_005266807.1

    UniProtKB/Swiss-Prot
    P15884
    Conserved Domains (1) summary
    cd00083
    Location:491551
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  21. XM_005266749.2XP_005266806.1  

    See proteins identical to XP_005266806.1

    Conserved Domains (1) summary
    cd00083
    Location:496556
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  22. XM_005266754.2XP_005266811.1  

    See proteins identical to XP_005266811.1

    Conserved Domains (1) summary
    cd00083
    Location:436496
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  23. XM_006722540.1XP_006722603.1  

    See proteins identical to XP_006722603.1

    UniProtKB/Swiss-Prot
    P15884
    Conserved Domains (1) summary
    cd00083
    Location:432492
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  24. XM_006722539.1XP_006722602.1  

    See proteins identical to XP_006722602.1

    Conserved Domains (1) summary
    cd00083
    Location:436496
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  25. XM_005266761.2XP_005266818.1  

    See proteins identical to XP_005266818.1

    Conserved Domains (1) summary
    cd00083
    Location:405465
    Blast Score: 139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

Alternate HuRef

Genomic

  1. AC_000150.1 

    Range
    49599225..50013477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018929.2 

    Range
    52884825..53298977
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)