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    Cdkn2a cyclin-dependent kinase inhibitor 2A [ Mus musculus (house mouse) ]

    Gene ID: 12578, updated on 28-Jun-2015
    Official Symbol
    Cdkn2aprovided by MGI
    Official Full Name
    cyclin-dependent kinase inhibitor 2Aprovided by MGI
    Primary source
    MGI:MGI:104738
    See related
    Ensembl:ENSMUSG00000044303; Vega:OTTMUSG00000007706
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arf; p16; MTS1; Pctr1; p19ARF; p16INK4a; p19<ARF>; ARF-INK4a; INK4a-ARF; Ink4a/Arf; p16(INK4a)
    See Cdkn2a in Epigenomics, MapViewer
    Location:
    4 42.15 cM; 4 C3-C6
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (89274473..89294619, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (88920377..88940523, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene TGFB-induced factor homeobox 2, pseudogene 1 Neighboring gene predicted gene 12606 Neighboring gene cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) Neighboring gene predicted gene 12609

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    plasmacytoma resistance 1
    GeneReviews: Not available

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Bladder cancer, organism-specific biosystem (from KEGG)
      Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Bladder cancer, conserved biosystem (from KEGG)
      Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle signaling pathway, organism-specific biosystem (from LIPID MAPS)
      Cell cycle signaling pathway, organism-specific biosystem
      Cell cycle signaling pathway
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
      G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
    • Glioma, organism-specific biosystem (from KEGG)
      Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Glioma, conserved biosystem (from KEGG)
      Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Melanoma, organism-specific biosystem (from KEGG)
      Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Melanoma, conserved biosystem (from KEGG)
      Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • Non-small cell lung cancer, organism-specific biosystem (from KEGG)
      Non-small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • Non-small cell lung cancer, conserved biosystem (from KEGG)
      Non-small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
      Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • PluriNetWork, organism-specific biosystem (from WikiPathways)
      PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
    • PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
      PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
    • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
      XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    MDM2/MDM4 family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cyclin-dependent protein serine/threonine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    poly(A) RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic mitochondrial changes ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell aging IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle arrest IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hydrogen peroxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular senescence IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion degradation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of immature T cell proliferation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of mammary gland epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of proteolysis involved in cellular protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of proteolysis involved in cellular protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of DNA damage response, signal transduction by p53 class mediator IC
    Inferred by Curator
    more info
    PubMed 
    positive regulation of DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process involved in mammary gland involution IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of macrophage apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    rRNA transcription IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of apoptotic DNA fragmentation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cyclin-dependent protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of nucleocytoplasmic transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    replicative senescence ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    response to organonitrogen compound ISO
    Inferred from Sequence Orthology
    more info
     
    senescence-associated heterochromatin focus assembly ISO
    Inferred from Sequence Orthology
    more info
     
    somatic stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somatic stem cell maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    granular component IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    senescence-associated heterochromatin focus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    cyclin-dependent kinase inhibitor 2A
    Names
    cyclin-dependent kinase inhibitor 2A
    CDK4I
    alternative reading frame
    cdkn2a
    cyclin-dependent kinase 4 inhibitor A
    cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4)
    cyclin-dependent kinase inhibitor 2A, isoform 3
    cyclin-dependent kinase inhibitor 2A, isoforms 1/2
    cyclin-dependent kinase inhibitor protein
    mitochondrial smARF
    p16-INK4
    p16-INK4a

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040654.1NP_001035744.1  cyclin-dependent kinase inhibitor 2A isoform 2

      See identical proteins and their annotated locations for NP_001035744.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate open reading frame (ARF), when compared to variant 1. The ARF results from an alternative splicing between a downstream first exon, which contains the translation start codon, and the common second exon. Thus, the protein encoded by this variant lacks sequence similarity to the protein product of variant 1. This protein is also called p16INK4a.
      Source sequence(s)
      AL831719, L76150
      Consensus CDS
      CCDS38812.1
      UniProtKB/Swiss-Prot
      P51480
      Related
      ENSMUSP00000061847, OTTMUSP00000008143, ENSMUST00000060501, OTTMUST00000017644
      Conserved Domains (3) summary
      cd00204
      Location:15122
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:45130
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:1556
      Ank_4; Ankyrin repeats (many copies)
    2. NM_009877.2NP_034007.1  cyclin-dependent kinase inhibitor 2A isoform 1

      See identical proteins and their annotated locations for NP_034007.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Isoform 1 is also called p19ARF.
      Source sequence(s)
      AL831719, L76092
      Consensus CDS
      CCDS18350.1
      UniProtKB/Swiss-Prot
      Q64364
      Related
      ENSMUSP00000102748, OTTMUSP00000008144, ENSMUST00000107131, OTTMUST00000017645
      Conserved Domains (1) summary
      pfam07392
      Location:445
      P19Arf_N; Cyclin-dependent kinase inhibitor 2a p19Arf N-terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

      Range
      89274473..89294619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000026.1 Alternate Mm_Celera

      Range
      87760902..87780610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)