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    MTOR mechanistic target of rapamycin [ Homo sapiens (human) ]

    Gene ID: 2475, updated on 24-Apr-2016
    Official Symbol
    MTORprovided by HGNC
    Official Full Name
    mechanistic target of rapamycinprovided by HGNC
    Primary source
    HGNC:HGNC:3942
    See related
    Ensembl:ENSG00000198793 HPRD:03134; MIM:601231; Vega:OTTHUMG00000002001
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SKS; FRAP; FRAP1; FRAP2; RAFT1; RAPT1
    Summary
    The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008]
    Orthologs
    Location:
    1p36.2
    Exon count:
    59
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (11106531..11262557, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11166588..11322614, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene exosome component 10 Neighboring gene spermidine synthase Neighboring gene uncharacterized LOC105376736 Neighboring gene MTOR antisense RNA 1 Neighboring gene angiopoietin like 7 Neighboring gene ribosomal protein L39 pseudogene 6 Neighboring gene ubiquitin conjugating enzyme E2 V2 pseudogene 3 Neighboring gene UbiA prenyltransferase domain containing 1 Neighboring gene uncharacterized LOC105376737

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore.
    NHGRI GWA Catalog
    CMPK1 and RBP3 are associated with corneal curvature in Asian populations.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Syncytia arising from the fusion of cells expressing HIV-1 gp120 with cells expressing the CD4/CXCR4 complex causes phosphorylation of p53, which is mediated by the upregulation of mammalian target of FKBP12-rapamycin-associated protein (FRAP) PubMed
    Nef nef HIV-1 Nef synergizes with KSHV oncoprotein K1 to activate PI3K/AKT/mTOR signaling pathway, and induces cell proliferation and microtubule formation in endothelial cells PubMed
    Tat tat HIV-1 Tat induces phosphorylation of mTOR in Tat-expressing cells and HIV-1-infected cells PubMed
    capsid gag Treatment with Torin 1, mTOR kinase inhibitor, significantly downregulates HIV-1 p24 levels in HIV-1-infected primary CD4+ T cells, Jurkat cells, and MOLT-X4 cells, suggesting mTOR kinase regulates HIV-1 production PubMed

    Go to the HIV-1, Human Interaction Database

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    • PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
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    • PKB-mediated events, organism-specific biosystem (from REACTOME)
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      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • RANKL/RANK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      RANKL/RANK Signaling Pathway, organism-specific biosystemRANKL (Receptor activator of nuclear factor-kappa B ligand), RANK (Receptor activator of nuclear factor-kappa B) and the natural decoy receptor of RANKL, OPG (Osteoprotegerin) are three important mol...
    • Regulation of Telomerase, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Telomerase, organism-specific biosystem
      Regulation of Telomerase
    • Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystem (from REACTOME)
      Role of LAT2/NTAL/LAB on calcium mobilization, organism-specific biosystemThe lipid raft resident adaptor molecules LAT1 and Non-T cell activation linker (NTAL), also known as linker for activation of B cells (LAB)/LAT2 are known participants in the regulation of mast cell...
    • SREBF and miR33 in cholesterol and lipid homeostasis, organism-specific biosystem (from WikiPathways)
      SREBF and miR33 in cholesterol and lipid homeostasis, organism-specific biosystemThis pathway describes transcription factor-microRNA circuits governing cholesterol and lipid homeostasis. It is based on a seminar by Dr. Anders N??r.
    • SREBP signalling, organism-specific biosystem (from WikiPathways)
      SREBP signalling, organism-specific biosystemSterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcript...
    • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
      Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by EGFR, organism-specific biosystem (from REACTOME)
      Signaling by EGFR, organism-specific biosystemThe epidermal growth factor receptor (EGFR) is one member of the ERBB family of transmembrane glycoprotein tyrosine receptor kinases (RTK). Binding of EGFR to its ligands induces conformational chang...
    • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
    • Signaling by FGFR, organism-specific biosystem (from REACTOME)
      Signaling by FGFR, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR1, organism-specific biosystem (from REACTOME)
      Signaling by FGFR1, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR2, organism-specific biosystem (from REACTOME)
      Signaling by FGFR2, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR3, organism-specific biosystem (from REACTOME)
      Signaling by FGFR3, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by FGFR4, organism-specific biosystem (from REACTOME)
      Signaling by FGFR4, organism-specific biosystemThe 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosin...
    • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
      Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
    • Signaling by PDGF, organism-specific biosystem (from REACTOME)
      Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...
    • Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
      Signaling by SCF-KIT, organism-specific biosystemStem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival...
    • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
      Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemBinding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS...
    • Signaling by VEGF, organism-specific biosystem (from REACTOME)
      Signaling by VEGF, organism-specific biosystemIn normal development vascular endothelial growth factors (VEGFs) are crucial regulators of vascular development during embryogenesis (vasculogenesis) and blood-vessel formation in the adult (angioge...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
    • Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met), organism-specific biosystem
      Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • TOR signaling, organism-specific biosystem (from WikiPathways)
      TOR signaling, organism-specific biosystemTOR signaling is responsible for a cellular reaction towards nutrient and energy availability and hypoxia/stress. The mammalian Target Of Rapamycin (mTOR), a serine/threonine kinase, is the central r...
    • TP53 Regulates Metabolic Genes, organism-specific biosystem (from REACTOME)
      TP53 Regulates Metabolic Genes, organism-specific biosystemThe tumor suppressor protein TP53 (p53) regulates transcription of a number of genes involved in the metabolism of carbohydrates, nucleotides and amino acids, protein synthesis and aerobic respiratio...
    • TSH signaling pathway, organism-specific biosystem (from WikiPathways)
      TSH signaling pathway, organism-specific biosystemHuman thyroid stimulating hormone (TSH) is a glycoprotein secreted by the anterior part of the pituitary gland (1). TSH plays an important physiological role in the regulation of the hypothalamic-pit...
    • TSLP Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TSLP Signaling Pathway, organism-specific biosystemThymic stromal lymphopoietin (TSLP) is a type I cytokine member of interleukin-2 cytokine family. TSLP signals through interleukin-7 receptor a chain (IL-7Ra) and the TSLP receptor subunit (TSLPR), h...
    • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
      Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...
    • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation by TP53, organism-specific biosystemTP53 (p53) regulates transcription of a number of genes involved in cellular metabolism, survival, senescence and DNA damage response. For a recent review, please refer to Vousden and Prives 2009.
    • Type II diabetes mellitus, organism-specific biosystem (from KEGG)
      Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • Type II diabetes mellitus, organism-specific biosystem (from WikiPathways)
      Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • Type II diabetes mellitus, conserved biosystem (from KEGG)
      Type II diabetes mellitus, conserved biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
    • VEGFA-VEGFR2 Pathway, organism-specific biosystem (from REACTOME)
      VEGFA-VEGFR2 Pathway, organism-specific biosystemAngiogenesis is the formation of new blood vessels from preexisting vasculature. One of the most important proangiogenic factors is vascular endothelial growth factor (VEGF). VEGF exerts its biologic...
    • VEGFR2 mediated vascular permeability, organism-specific biosystem (from REACTOME)
      VEGFR2 mediated vascular permeability, organism-specific biosystemThe free radical nitric oxide (NO), produced by endothelial NO synthase (eNOS), is an important vasoactive substance in normal vascular biology and pathophysiology. It plays an important role in vasc...
    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystem
      mTOR signaling pathway
    • mTOR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      mTOR signaling pathway, organism-specific biosystem
      mTOR signaling pathway
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystem
      mTOR signaling pathway
    • mTOR signalling, organism-specific biosystem (from REACTOME)
      mTOR signalling, organism-specific biosystemTarget of rapamycin (mTOR) is a highly-conserved serine/threonine kinase that regulates cell growth and division in response to energy levels, growth signals, and nutrients (Zoncu et al. 2011). Contr...
    • mTORC1-mediated signalling, organism-specific biosystem (from REACTOME)
      mTORC1-mediated signalling, organism-specific biosystemmTORC1 integrates four major signals growth factors, energy status, oxygen and amino acids to regulate many processes that are involved in the promotion of cell growth. Growth factors stimulate mTO...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ44809

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase III type 1 promoter DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase III type 2 promoter DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase III type 3 promoter DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    TFIIIC-class transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    drug binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    phosphoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    ribosome binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    'de novo' pyrimidine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    T cell costimulation TAS
    Traceable Author Statement
    more info
     
    TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    brain development IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac muscle cell development IEA
    Inferred from Electronic Annotation
    more info
     
    cardiac muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    cell aging IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle arrest TAS
    Traceable Author Statement
    more info
     
    cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell growth TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to hypoxia ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to nutrient levels ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    energy reserve metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    germ cell development IEA
    Inferred from Electronic Annotation
    more info
     
    growth NAS
    Non-traceable Author Statement
    more info
    PubMed 
    heart morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    heart valve morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    long-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA stabilization IEA
    Inferred from Electronic Annotation
    more info
     
    macroautophagy TAS
    Traceable Author Statement
    more info
     
    maternal process involved in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of NFAT protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell size IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cholangiocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of iodide transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of macroautophagy IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of muscle atrophy IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-threonine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol-mediated signaling TAS
    Traceable Author Statement
    more info
     
    phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell growth involved in cardiac muscle cell development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cholangiocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of dendritic spine development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of eating behavior IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of granulosa cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of lamellipodium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of lipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of myotube differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron death IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron maturation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein kinase B signaling IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of skeletal muscle hypertrophy IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase III promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of carbohydrate utilization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cellular response to heat TAS
    Traceable Author Statement
    more info
     
    regulation of fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of membrane permeability IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of myelination IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of osteoclast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of response to food IEA
    Inferred from Electronic Annotation
    more info
     
    response to amino acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    response to morphine IEA
    Inferred from Electronic Annotation
    more info
     
    response to nutrient NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ruffle organization IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    social behavior IEA
    Inferred from Electronic Annotation
    more info
     
    spinal cord development IEA
    Inferred from Electronic Annotation
    more info
     
    visual learning IEA
    Inferred from Electronic Annotation
    more info
     
    voluntary musculoskeletal movement IEA
    Inferred from Electronic Annotation
    more info
     
    wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with PML body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    TORC1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    TORC1 complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    TORC2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    endomembrane system IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phosphatidylinositol 3-kinase complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Preferred Names
    serine/threonine-protein kinase mTOR
    Names
    FK506 binding protein 12-rapamycin associated protein 2
    FK506-binding protein 12-rapamycin complex-associated protein 1
    FKBP-rapamycin associated protein
    FKBP12-rapamycin complex-associated protein 1
    mammalian target of rapamycin
    mechanistic target of rapamycin (serine/threonine kinase)
    rapamycin and FKBP12 target 1
    rapamycin associated protein FRAP2
    rapamycin target protein 1
    NP_004949.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033239.1 RefSeqGene

      Range
      5001..161021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_734

    mRNA and Protein(s)

    1. NM_004958.3NP_004949.1  serine/threonine-protein kinase mTOR

      See identical proteins and their annotated locations for NP_004949.1

      Status: REVIEWED

      Source sequence(s)
      AA725390, AB209995, BC117166, BP250183, DC403129, L34075, U88966
      Consensus CDS
      CCDS127.1
      UniProtKB/Swiss-Prot
      P42345
      Related
      ENSP00000354558, OTTHUMP00000001983, ENST00000361445, OTTHUMT00000005558
      Conserved Domains (6) summary
      COG5032
      Location:3632549
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      pfam02260
      Location:25192549
      FATC; FATC domain
      pfam08771
      Location:20152114
      Rapamycin_bind; Rapamycin binding domain
      pfam11865
      Location:8541024
      DUF3385; Domain of unknown function (DUF3385)
      pfam13513
      Location:748805
      HEAT_EZ; HEAT-like repeat
      cd05169
      Location:21532431
      PIKKc_TOR; Catalytic domain of Target of Rapamycin

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

      Range
      11106531..11262557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005263438.1XP_005263495.1  

      See identical proteins and their annotated locations for XP_005263495.1

      UniProtKB/Swiss-Prot
      P42345
      Conserved Domains (6) summary
      COG5032
      Location:3632549
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      pfam02260
      Location:25192549
      FATC; FATC domain
      pfam08771
      Location:20152114
      Rapamycin_bind; Rapamycin binding domain
      pfam11865
      Location:8541024
      DUF3385; Domain of unknown function (DUF3385)
      pfam13513
      Location:748805
      HEAT_EZ; HEAT-like repeat
      cd05169
      Location:21532431
      PIKKc_TOR; Catalytic domain of Target of Rapamycin
    2. XM_011541166.1XP_011539468.1  

      Conserved Domains (3) summary
      COG5032
      Location:3631587
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      pfam11865
      Location:8541024
      DUF3385; Domain of unknown function (DUF3385)
      pfam13513
      Location:748805
      HEAT_EZ; HEAT-like repeat

    RNA

    1. XR_244786.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      11154542..11310885 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)