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Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b [ Rattus norvegicus (Norway rat) ]

Gene ID: 156767, updated on 8-Dec-2014
Official Symbol
Tnfrsf1bprovided by RGD
Official Full Name
tumor necrosis factor receptor superfamily, member 1bprovided by RGD
Primary source
RGD:621238
See related
Ensembl:ENSRNOG00000016575
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Tnfr2
Summary
mediates brain uptake of tumor necrosis factor (TNF)-alpha from the circulation [RGD, Feb 2006]
See Tnfrsf1b in MapViewer
Location:
5q36
Exon count:
10
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (163136390..163167299, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (166815372..166845910, complement)

Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 13 homolog D (S. cerevisiae) Neighboring gene 60S ribosomal protein L36-like Neighboring gene tumor necrosis factor receptor superfamily, member 8 Neighboring gene hypothetical LOC100361514

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
    Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Adipocytokine signaling pathway, conserved biosystem (from KEGG)
    Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
  • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
    Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
  • Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
    Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
  • Apoptosis, organism-specific biosystem (from WikiPathways)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
  • Inflammatory Response Pathway, organism-specific biosystem (from WikiPathways)
    Inflammatory Response Pathway, organism-specific biosystem
    Inflammatory Response Pathway
  • TNF signaling pathway, organism-specific biosystem (from KEGG)
    TNF signaling pathway, organism-specific biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
  • TNF signaling pathway, conserved biosystem (from KEGG)
    TNF signaling pathway, conserved biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
  • TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem
    TNF-alpha NF-kB Signaling Pathway

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
tumor necrosis factor-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
tumor necrosis factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
RNA destabilization IEA
Inferred from Electronic Annotation
more info
 
RNA destabilization ISO
Inferred from Sequence Orthology
more info
 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cellular response to growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
immune response IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
inflammatory response ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
programmed cell death ISO
Inferred from Sequence Orthology
more info
 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
varicosity IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
tumor necrosis factor receptor superfamily member 1B
Names
tumor necrosis factor receptor superfamily member 1B
p75
TNF-R2
TNF-RII
TNFR-II
p80 TNF-alpha receptor
tumor necrosis factor receptor 2
tumor necrosis factor receptor type II

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130426.4NP_569110.1  tumor necrosis factor receptor superfamily member 1B precursor

    See proteins identical to NP_569110.1

    Status: PROVISIONAL

    Source sequence(s)
    AF498039
    UniProtKB/Swiss-Prot
    Q80WY6
    Related
    ENSRNOP00000022478, ENSRNOT00000022478
    Conserved Domains (1) summary
    cd00185
    Location:40139
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005104.4 

    Range
    163136390..163167299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000073.1 

    Range
    155362574..155393443
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)