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Smad3 SMAD family member 3 [ Mus musculus (house mouse) ]

Gene ID: 17127, updated on 8-Jul-2014
Official Symbol
Smad3provided by MGI
Official Full Name
SMAD family member 3provided by MGI
Primary source
MGI:1201674
Locus tag
RP23-63E8.1
See related
Ensembl:ENSMUSG00000032402; Vega:OTTMUSG00000021500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Madh3; AU022421
See Smad3 in Epigenomics, MapViewer
Location:
9 D; 9
Exon count :
12
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 9 NC_000075.6 (63646766..63757994, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene IQ motif containing H Neighboring gene uncharacterized LOC102639510 Neighboring gene alpha- and gamma-adaptin binding protein Neighboring gene uncharacterized LOC102639687 Neighboring gene COMM domain containing 9 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding ISO
Inferred from Sequence Orthology
more info
 
R-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II activating transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
SMAD binding ISO
Inferred from Sequence Orthology
more info
 
bHLH transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
co-SMAD binding ISO
Inferred from Sequence Orthology
more info
 
collagen binding IPI
Inferred from Physical Interaction
more info
PubMed 
core promoter proximal region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to protein binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor binding ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
SMAD protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction organization ISO
Inferred from Sequence Orthology
more info
 
developmental growth IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic cranial skeleton morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic foregut morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic pattern specification IGI
Inferred from Genetic Interaction
more info
PubMed 
endoderm development IGI
Inferred from Genetic Interaction
more info
PubMed 
evasion or tolerance of host defenses by virus ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
gastrulation IGI
Inferred from Genetic Interaction
more info
PubMed 
heart looping IGI
Inferred from Genetic Interaction
more info
PubMed 
immune response ISO
Inferred from Sequence Orthology
more info
 
immune system development IGI
Inferred from Genetic Interaction
more info
PubMed 
in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
lens fiber cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
liver development IGI
Inferred from Genetic Interaction
more info
PubMed 
mesoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of osteoblast proliferation IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
nodal signaling pathway ISO
Inferred from Sequence Orthology
more info
 
osteoblast development IGI
Inferred from Genetic Interaction
more info
PubMed 
osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
paraxial mesoderm morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
pericardium development IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of alkaline phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of catenin import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chondrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression involved in extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription factor import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transforming growth factor beta3 production ISO
Inferred from Sequence Orthology
more info
 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
regulation of binding IDA
Inferred from Direct Assay
more info
PubMed 
regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of striated muscle tissue development IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of transforming growth factor beta2 production ISO
Inferred from Sequence Orthology
more info
 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
signal transduction involved in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
skeletal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
thyroid gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transdifferentiation ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
SMAD protein complex ISO
Inferred from Sequence Orthology
more info
 
SMAD2-SMAD3 protein complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
intracellular IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein complex ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
mothers against decapentaplegic homolog 3
Names
mothers against decapentaplegic homolog 3
mad3
mMad3
Smad 3
MAD homolog 3
mothers against DPP homolog 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016769.4NP_058049.3  mothers against decapentaplegic homolog 3

    See proteins identical to NP_058049.3

    Status: VALIDATED

    Source sequence(s)
    AC158515, AK048626, AK083158
    Consensus CDS
    CCDS23272.1
    UniProtKB/Swiss-Prot
    Q8BUN5
    Related
    ENSMUSP00000034973, OTTMUSP00000023917, ENSMUST00000034973, OTTMUST00000050960
    Conserved Domains (2) summary
    cd10491
    Location:8132
    Blast Score: 664
    MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
    cd10985
    Location:224414
    Blast Score: 1137
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000075.6 

    Range
    63646766..63757994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510820.1XP_006510883.1  

    Conserved Domains (2) summary
    cd10985
    Location:157347
    Blast Score: 1135
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    cl00055
    Location:265
    Blast Score: 417
    MH1; N-terminal Mad Homology 1 (MH1) domain
  2. XM_006510819.1XP_006510882.1  

    Conserved Domains (2) summary
    cd10985
    Location:192382
    Blast Score: 1137
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    cl00055
    Location:37100
    Blast Score: 412
    MH1; N-terminal Mad Homology 1 (MH1) domain
  3. XM_006510821.1XP_006510884.1  

    See proteins identical to XP_006510884.1

    Conserved Domains (1) summary
    cd10985
    Location:29219
    Blast Score: 1125
    MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

Alternate Mm_Celera

Genomic

  1. AC_000031.1 

    Range
    60869117..60980879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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