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DICER1 dicer 1, ribonuclease type III [ Homo sapiens (human) ]

Gene ID: 23405, updated on 11-Sep-2014
Official Symbol
DICER1provided by HGNC
Official Full Name
dicer 1, ribonuclease type IIIprovided by HGNC
Primary source
HGNC:HGNC:17098
See related
Ensembl:ENSG00000100697; HPRD:05875; MIM:606241; Vega:OTTHUMG00000166134
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCR1; MNG1; Dicer; HERNA; RMSE2; Dicer1e
Summary
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
See DICER1 in Epigenomics, MapViewer
Location:
14q32.13
Exon count:
30
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 14 NC_000014.9 (95086228..95157422, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (95552565..95623759, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene goosecoid homeobox Neighboring gene ribosomal protein L15 pseudogene 2 Neighboring gene DICER1 antisense RNA 1 Neighboring gene microRNA 3173 Neighboring gene calmin (calponin-like, transmembrane)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Goiter, multinodular 1, with or without sertoli-leydig cell tumors
MedGen: C0018022 OMIM: 138800 GeneReviews: Not available
Compare labs
Pleuropulmonary blastoma
MedGen: C1266144 OMIM: 601200 GeneReviews: Not available
Compare labs
Rhabdomyosarcoma, embryonal, 2
MedGen: C1867234 OMIM: 180295 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
NHGRI GWA Catalog
Genome-wide association of lipid-lowering response to statins in combined study populations.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of dicer 1, ribonuclease type III (DICER1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev The arginine rich motif (residues 35-50) of HIV-1 Rev inhibits Dicer dependent RNAi process PubMed
Tat tat The arginine rich motif (residues 48-58) of HIV-1 Tat inhibits Dicer dependent RNAi process PubMed
tat HIV-1 Tat-Dicer interaction requires RNA; Dicer's helicase domain (residues 246-585) and a portion of Tat amino acids 30-72 are involved in the interaction PubMed
Vpr vpr HIV-1 Vpr-induced downregulation of Dicer is not dependent on G2 cell cycle arrest but on the Cul4A-DCAF1-DDB1 ubiquitin ligase complex PubMed
vpr HIV-1 Vpr complexes with Dicer and induces downregulation of Dicer in HIV-1 infected cells PubMed

Go to the HIV-1, Human Interaction Database

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • MicroRNA (miRNA) biogenesis, organism-specific biosystem (from REACTOME)
    MicroRNA (miRNA) biogenesis, organism-specific biosystemBiogenesis of microRNAs (miRNAs) can be summarized in five steps (reviewed in Ketting 2011, Nowotny and Yang 2009, Kim et al. 2009, Chua et al. 2009, Hannon and He 2004):1. Transcription. miRNA trans...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • Regulatory RNA pathways, organism-specific biosystem (from REACTOME)
    Regulatory RNA pathways, organism-specific biosystemIn this module, the biology of various types of regulatory non-coding RNAs are described. Currently, biogenesis and functions of small interfering RNAs (siRNAs) and microRNAs are annotated.
  • Small interfering RNA (siRNA) biogenesis, organism-specific biosystem (from REACTOME)
    Small interfering RNA (siRNA) biogenesis, organism-specific biosystemSmall interfering RNAs (siRNAs) are 21-25 nucleotide single-stranded RNAs produced by cleavage of longer double-stranded RNAs by the enzyme Dicer. Typically the long double-stranded substrates origin...
  • mRNA processing, organism-specific biosystem (from WikiPathways)
    mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0928

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
miRNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribonuclease III activity IDA
Inferred from Direct Assay
more info
 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis IDA
Inferred from Direct Assay
more info
 
RNA phosphodiester bond hydrolysis, endonucleolytic IDA
Inferred from Direct Assay
more info
 
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
branching morphogenesis of an epithelial tube IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
cerebral cortex development IEA
Inferred from Electronic Annotation
more info
 
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
embryonic hindlimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
gene expression TAS
Traceable Author Statement
more info
 
hair follicle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
inner ear receptor cell development IEA
Inferred from Electronic Annotation
more info
 
intestinal epithelial cell development IEA
Inferred from Electronic Annotation
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
mRNA stabilization IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Schwann cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
nerve development ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
olfactory bulb interneuron differentiation IEA
Inferred from Electronic Annotation
more info
 
peripheral nervous system myelin formation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Schwann cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of miRNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of myelination ISS
Inferred from Sequence or Structural Similarity
more info
 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
pre-miRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
production of miRNAs involved in gene silencing by miRNA ISS
Inferred from Sequence or Structural Similarity
more info
 
production of siRNA involved in RNA interference IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of enamel mineralization IEA
Inferred from Electronic Annotation
more info
 
regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of viral genome replication IEA
Inferred from Electronic Annotation
more info
 
reproductive structure development IEA
Inferred from Electronic Annotation
more info
 
spinal cord motor neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
spindle assembly IEA
Inferred from Electronic Annotation
more info
 
spleen development IEA
Inferred from Electronic Annotation
more info
 
stem cell maintenance IEA
Inferred from Electronic Annotation
more info
 
targeting of mRNA for destruction involved in RNA interference IMP
Inferred from Mutant Phenotype
more info
PubMed 
zygote asymmetric cell division IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RISC complex IDA
Inferred from Direct Assay
more info
PubMed 
axon IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
 
growth cone IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
endoribonuclease Dicer
Names
endoribonuclease Dicer
K12H4.8-LIKE
helicase MOI
helicase-moi
Dicer1, Dcr-1 homolog
multinodular goitre 1
helicase with RNAse motif
dicer 1, double-stranded RNA-specific endoribonuclease
NP_001182502.1
NP_001258211.1
NP_085124.2
NP_803187.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016311.1 

    Range
    4413..76195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_492

mRNA and Protein(s)

  1. NM_001195573.1NP_001182502.1  endoribonuclease Dicer isoform 2

    See proteins identical to NP_001182502.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 2. The resulting isoform 2 (also called t-Dicer) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL356017, AL390254, HM595745
    Consensus CDS
    CCDS55941.1
    UniProtKB/Swiss-Prot
    Q9UPY3
    Conserved Domains (8) summary
    smart00487
    Location:40242
    DEXDc; DEAD-like helicases superfamily
    COG0513
    Location:445589
    SrmB; Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]
    COG0571
    Location:16661765
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd00046
    Location:58209
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:444553
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00593
    Location:16821767
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    pfam03368
    Location:630722
    Dicer_dimer; Dicer dimerization domain
  2. NM_001271282.2NP_001258211.1  endoribonuclease Dicer isoform 1

    See proteins identical to NP_001258211.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 2. Variants 1, 2, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AF007142, AJ132261, AL390254
    Consensus CDS
    CCDS9931.1
    UniProtKB/Swiss-Prot
    Q9UPY3
    Related
    ENSP00000435681, OTTHUMP00000231972, ENST00000527414, OTTHUMT00000387999
    Conserved Domains (9) summary
    smart00487
    Location:40242
    DEXDc; DEAD-like helicases superfamily
    COG0513
    Location:445589
    SrmB; Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd00046
    Location:58209
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00048
    Location:18501912
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd00079
    Location:444553
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00593
    Location:16821846
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    pfam03368
    Location:630722
    Dicer_dimer; Dicer dimerization domain
  3. NM_001291628.1NP_001278557.1  endoribonuclease Dicer isoform 1

    See proteins identical to NP_001278557.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an internal segment in the 5' UTR, compared to variant 2. Variants 1, 2, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AF007142, AJ132261, AL390254, AY845868, BM152875
    UniProtKB/Swiss-Prot
    Q9UPY3
    Conserved Domains (9) summary
    smart00487
    Location:40242
    DEXDc; DEAD-like helicases superfamily
    COG0513
    Location:445589
    SrmB; Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd00046
    Location:58209
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00048
    Location:18501912
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd00079
    Location:444553
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00593
    Location:16821846
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    pfam03368
    Location:630722
    Dicer_dimer; Dicer dimerization domain
  4. NM_030621.4NP_085124.2  endoribonuclease Dicer isoform 1

    See proteins identical to NP_085124.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 1, 2, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AF007142, AJ132261, AL390254, AY845867, BM152875
    Consensus CDS
    CCDS9931.1
    UniProtKB/Swiss-Prot
    Q9UPY3
    Related
    ENSP00000376783, ENST00000393063
    Conserved Domains (9) summary
    smart00487
    Location:40242
    DEXDc; DEAD-like helicases superfamily
    COG0513
    Location:445589
    SrmB; Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd00046
    Location:58209
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00048
    Location:18501912
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd00079
    Location:444553
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00593
    Location:16821846
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    pfam03368
    Location:630722
    Dicer_dimer; Dicer dimerization domain
  5. NM_177438.2NP_803187.1  endoribonuclease Dicer isoform 1

    See proteins identical to NP_803187.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1, 2, 4 and 5 encode the same isoform (1).
    Source sequence(s)
    AF007142, AL390254, BC150287
    Consensus CDS
    CCDS9931.1
    UniProtKB/Swiss-Prot
    Q9UPY3
    Related
    ENSP00000343745, OTTHUMP00000231970, ENST00000343455, OTTHUMT00000387996
    Conserved Domains (9) summary
    smart00487
    Location:40242
    DEXDc; DEAD-like helicases superfamily
    COG0513
    Location:445589
    SrmB; Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]
    COG0571
    Location:16661918
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cd00046
    Location:58209
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00048
    Location:18501912
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    cd00079
    Location:444553
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00593
    Location:16821846
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    cd02843
    Location:8861008
    PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    pfam03368
    Location:630722
    Dicer_dimer; Dicer dimerization domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000014.9 

    Range
    95086228..95157422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000146.1 

    Range
    75736521..75807615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 

    Range
    95490915..95561989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)