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    Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) [ Mus musculus (house mouse) ]

    Gene ID: 11606, updated on 3-Jul-2016
    Official Symbol
    Agtprovided by MGI
    Official Full Name
    angiotensinogen (serpin peptidase inhibitor, clade A, member 8)provided by MGI
    Primary source
    MGI:MGI:87963
    See related
    Ensembl:ENSMUSG00000031980
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AngI; AngII; Aogen; AI265500; Serpina8
    Orthologs
    Location:
    8 E2; 8 72.81 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (124556587..124569707, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (127080487..127093607, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39280 Neighboring gene component of oligomeric golgi complex 2 Neighboring gene calpain 9 Neighboring gene RIKEN cDNA 2310022B05 gene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    angiotensin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    type 1 angiotensin receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    type 1 angiotensin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    type 2 angiotensin receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    type 2 angiotensin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    activation of NF-kappaB-inducing kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of phospholipase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure IDA
    Inferred from Direct Assay
    more info
    PubMed 
    angiotensin-mediated drinking behavior ISO
    Inferred from Sequence Orthology
    more info
     
    artery smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    astrocyte activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    brain renin-angiotensin system IDA
    Inferred from Direct Assay
    more info
    PubMed 
    branching involved in ureteric bud morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT branching involved in ureteric bud morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    catenin import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular sodium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    drinking behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of blood-nerve barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    excretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    hormone metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neurotrophin TRK receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tissue remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    ovarian follicle rupture IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peristalsis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of L-arginine import into cell ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of L-lysine import into cell ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of activation of JAK2 kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of branching involved in ureteric bud morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cellular protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cholesterol esterification ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytokine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of extracellular matrix constituent secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gap junction assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of glucose import in response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of organ growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase C activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of renal sodium excretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vasodilation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of extracellular matrix assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of long-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of norepinephrine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of renal output by angiotensin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of renal sodium excretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of systemic arterial blood pressure by circulatory renin-angiotensin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transmission of nerve impulse ISO
    Inferred from Sequence Orthology
    more info
     
    renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    renal system process ISO
    Inferred from Sequence Orthology
    more info
     
    renin-angiotensin regulation of aldosterone production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    renin-angiotensin regulation of aldosterone production ISO
    Inferred from Sequence Orthology
    more info
     
    response to cold IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to muscle activity involved in regulation of muscle adaptation ISO
    Inferred from Sequence Orthology
    more info
     
    response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    smooth muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    smooth muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    uterine smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    vasodilation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    blood microparticle ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    angiotensinogen
    Names
    angiotensin I
    angiotensin ll
    serpin A8

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007428.3NP_031454.3  angiotensinogen

      See identical proteins and their annotated locations for NP_031454.3

      Status: VALIDATED

      Source sequence(s)
      AK139179, BB869708, BM899343
      Consensus CDS
      CCDS40513.1
      UniProtKB/TrEMBL
      Q3UTR7
      Related
      ENSMUSP00000066488, ENSMUST00000063278
      Conserved Domains (1) summary
      cl00137
      Location:102478
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      124556587..124569707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)