Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    PRDX1 peroxiredoxin 1 [ Homo sapiens (human) ]

    Gene ID: 5052, updated on 19-Jul-2016
    Official Symbol
    PRDX1provided by HGNC
    Official Full Name
    peroxiredoxin 1provided by HGNC
    Primary source
    HGNC:HGNC:9352
    See related
    Ensembl:ENSG00000117450 HPRD:01458; MIM:176763; Vega:OTTHUMG00000007738
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAG; PAGA; PAGB; PRX1; PRXI; MSP23; NKEFA; TDPX2; NKEF-A
    Summary
    This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Four transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jan 2011]
    Orthologs
    Location:
    1p34.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (45511035..45522890, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (45976707..45988562, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene target of EGR1, member 1 (nuclear) Neighboring gene testis-specific kinase 2 Neighboring gene coiled-coil domain containing 163 Neighboring gene methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria Neighboring gene high mobility group box 1 pseudogene 48 Neighboring gene aldo-keto reductase family 1 member A1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of peroxiredoxin 1, 3, and 4 proteins in umbilical cord blood mononuclear cells and T-cell lines PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human peroxiredoxin 1 (PRDX1) at amino acid residues 49-50 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
    • Coregulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
      Coregulation of Androgen receptor activity, organism-specific biosystem
      Coregulation of Androgen receptor activity
    • Detoxification of Reactive Oxygen Species, organism-specific biosystem (from REACTOME)
      Detoxification of Reactive Oxygen Species, organism-specific biosystemReactive oxygen species such as superoxide (O2.-), peroxides (ROOR), singlet oxygen, peroxynitrite (ONOO-), and hydroxyl radical (OH.) are generated by cellular processes such as respiration (reviewe...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • Peroxisome, organism-specific biosystem (from KEGG)
      Peroxisome, organism-specific biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
    • Peroxisome, conserved biosystem (from KEGG)
      Peroxisome, conserved biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
    • Selenium Pathway, organism-specific biosystem (from WikiPathways)
      Selenium Pathway, organism-specific biosystem
      Selenium Pathway
    • TP53 Regulates Metabolic Genes, organism-specific biosystem (from REACTOME)
      TP53 Regulates Metabolic Genes, organism-specific biosystemWhile the p53 tumor suppressor protein (TP53) is known to inhibit cell growth by inducing apoptosis, senescence and cell cycle arrest, recent studies have found that p53 is also able to influence cel...
    • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cadherin binding involved in cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    peroxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thioredoxin peroxidase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    thioredoxin peroxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    cell redox homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    erythrocyte homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    hydrogen peroxide catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    natural killer cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of NF-kappaB import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of stress-activated MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    removal of superoxide radicals IEA
    Inferred from Electronic Annotation
    more info
     
    response to reactive oxygen species TAS
    Traceable Author Statement
    more info
     
    retina homeostasis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    skeletal system development TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    peroxiredoxin-1
    Names
    natural killer cell-enhancing factor A
    natural killer-enhancing factor A
    proliferation-associated gene A
    proliferation-associated gene protein
    thioredoxin peroxidase 2
    thioredoxin-dependent peroxide reductase 2
    NP_001189360.1
    NP_002565.1
    NP_859047.1
    NP_859048.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001202431.1NP_001189360.1  peroxiredoxin-1

      See identical proteins and their annotated locations for NP_001189360.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains a different exon for part of its 5' UTR, compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AI912389, BM740381, BM787105
      Consensus CDS
      CCDS522.1
      UniProtKB/Swiss-Prot
      Q06830
      Related
      ENSP00000389047, OTTHUMP00000009237, ENST00000424390, OTTHUMT00000020848
      Conserved Domains (2) summary
      PTZ00253
      Location:1196
      PTZ00253; tryparedoxin peroxidase; Provisional
      cd03015
      Location:8180
      PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
    2. NM_002574.3NP_002565.1  peroxiredoxin-1

      See identical proteins and their annotated locations for NP_002565.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
      Source sequence(s)
      AB451388, AI912389, BM827394, CD638470
      Consensus CDS
      CCDS522.1
      UniProtKB/Swiss-Prot
      Q06830
      Related
      ENSP00000262746, ENST00000262746
      Conserved Domains (2) summary
      PTZ00253
      Location:1196
      PTZ00253; tryparedoxin peroxidase; Provisional
      cd03015
      Location:8180
      PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
    3. NM_181696.2NP_859047.1  peroxiredoxin-1

      See identical proteins and their annotated locations for NP_859047.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AB451388, AI912389, BM762399, CD638470
      Consensus CDS
      CCDS522.1
      UniProtKB/Swiss-Prot
      Q06830
      Conserved Domains (2) summary
      PTZ00253
      Location:1196
      PTZ00253; tryparedoxin peroxidase; Provisional
      cd03015
      Location:8180
      PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
    4. NM_181697.2NP_859048.1  peroxiredoxin-1

      See identical proteins and their annotated locations for NP_859048.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AI912389, BC021683, CD638470
      Consensus CDS
      CCDS522.1
      UniProtKB/Swiss-Prot
      Q06830
      Related
      ENSP00000361152, OTTHUMP00000009234, ENST00000319248, OTTHUMT00000020845
      Conserved Domains (2) summary
      PTZ00253
      Location:1196
      PTZ00253; tryparedoxin peroxidase; Provisional
      cd03015
      Location:8180
      PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      45511035..45522890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      46093972..46105688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)