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    TNFSF8 tumor necrosis factor superfamily member 8 [ Homo sapiens (human) ]

    Gene ID: 944, updated on 19-Jul-2016
    Official Symbol
    TNFSF8provided by HGNC
    Official Full Name
    tumor necrosis factor superfamily member 8provided by HGNC
    Primary source
    HGNC:HGNC:11938
    See related
    Ensembl:ENSG00000106952 HPRD:04852; MIM:603875; Vega:OTTHUMG00000021025
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD153; CD30L; CD30LG; TNLG3A
    Summary
    The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
    Orthologs
    Location:
    9q33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 9 NC_000009.12 (114893343..114930595, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (117655623..117692875, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor superfamily member 15 Neighboring gene pre-mRNA processing factor 4B pseudogene Neighboring gene tenascin C Neighboring gene uncharacterized LOC101928748

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.
    NHGRI GWA Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog
    IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L.
    NHGRI GWA Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif upregulates the expression of tumor necrosis factor ligand superfamily, member 8 (TNFSF8) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC138144

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    CD8-positive, alpha-beta T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    tumor necrosis factor ligand superfamily member 8
    Names
    CD153 antigen
    CD30 antigen ligand
    CD30 ligand
    CD30-L
    tumor necrosis factor (ligand) superfamily member 8
    tumor necrosis factor (ligand) superfamily, member 8
    tumor necrosis factor ligand 3A

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001244.3NP_001235.1  tumor necrosis factor ligand superfamily member 8 isoform 1

      See identical proteins and their annotated locations for NP_001235.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA748015, AK313619, AL133412
      Consensus CDS
      CCDS6810.1
      UniProtKB/Swiss-Prot
      P32971
      UniProtKB/TrEMBL
      Q52M88
      Related
      ENSP00000223795, OTTHUMP00000022762, ENST00000223795, OTTHUMT00000055464
      Conserved Domains (1) summary
      pfam00229
      Location:113230
      TNF; TNF(Tumour Necrosis Factor) family
    2. NM_001252290.1NP_001239219.1  tumor necrosis factor ligand superfamily member 8 isoform 2

      See identical proteins and their annotated locations for NP_001239219.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region of the last exon and contains an alternate downstream exon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK313619, AW118787, BX108999, CD690231
      Consensus CDS
      CCDS75884.1
      UniProtKB/TrEMBL
      A0A087X228, Q52M88
      Related
      ENSP00000484651, ENST00000618336

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p7 Primary Assembly

      Range
      114893343..114930595 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001746422.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018920.2 Alternate CHM1_1.1

      Range
      117802301..117839555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)