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    POU3F4 POU class 3 homeobox 4 [ Homo sapiens (human) ]

    Gene ID: 5456, updated on 29-Jun-2016
    Official Symbol
    POU3F4provided by HGNC
    Official Full Name
    POU class 3 homeobox 4provided by HGNC
    Primary source
    HGNC:HGNC:9217
    See related
    Ensembl:ENSG00000196767 HPRD:02076; MIM:300039; Vega:OTTHUMG00000021919
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BRN4; DFN3; OTF9; BRN-4; DFNX2; OCT-9; OTF-9; BRAIN-4
    Summary
    This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012]
    Orthologs
    Location:
    Xq21.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) X NC_000023.11 (83508261..83509767)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (82763269..82764775)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene autophagy related 4A cysteine peptidase pseudogene 1 Neighboring gene uncharacterized LOC107985635 Neighboring gene proteasome maturation protein pseudogene Neighboring gene telomeric repeat binding factor 1 pseudogene 4

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    AT DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cochlea morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    forebrain neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of mesenchymal cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    POU domain, class 3, transcription factor 4
    Names
    brain-specific homeobox/POU domain protein 4
    octamer-binding transcription factor 9

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009936.2 RefSeqGene

      Range
      5001..6507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000307.4NP_000298.3  POU domain, class 3, transcription factor 4

      See identical proteins and their annotated locations for NP_000298.3

      Status: REVIEWED

      Source sequence(s)
      AK314967, X82324, Z82170
      Consensus CDS
      CCDS14450.1
      UniProtKB/Swiss-Prot
      P49335
      Related
      ENSP00000362296, OTTHUMP00000023616, ENST00000373200, OTTHUMT00000057368
      Conserved Domains (2) summary
      smart00352
      Location:186260
      POU; Found in Pit-Oct-Unc transcription factors
      cd00086
      Location:279336
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p7 Primary Assembly

      Range
      83508261..83509767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018934.2 Alternate CHM1_1.1

      Range
      82657165..82658671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)