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TAL1 T-cell acute lymphocytic leukemia 1 [ Homo sapiens (human) ]

Gene ID: 6886, updated on 11-Sep-2014
Official Symbol
TAL1provided by HGNC
Official Full Name
T-cell acute lymphocytic leukemia 1provided by HGNC
Primary source
HGNC:HGNC:11556
See related
Ensembl:ENSG00000162367; HPRD:01753; MIM:187040; Vega:OTTHUMG00000007847
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCL; TCL5; tal-1; bHLHa17
See TAL1 in Epigenomics, MapViewer
Location:
1p32
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (47216290..47232266, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (47681962..47697938, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 853 Neighboring gene PDZK1 interacting protein 1 Neighboring gene SCL/TAL1 interrupting locus Neighboring gene cytidine monophosphate (UMP-CMP) kinase 1, cytosolic

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
E-box binding IDA
Inferred from Direct Assay
more info
 
RNA polymerase II core promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding RNA polymerase II transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
astrocyte fate commitment IEA
Inferred from Electronic Annotation
more info
 
basophil differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
cell fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
definitive hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
embryonic hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
 
erythrocyte differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
erythrocyte maturation IEA
Inferred from Electronic Annotation
more info
 
hemangioblast cell differentiation IEA
Inferred from Electronic Annotation
more info
 
hematopoietic stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
 
locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
megakaryocyte development IEA
Inferred from Electronic Annotation
more info
 
megakaryocyte differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
platelet formation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell division IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of chromatin assembly or disassembly IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of erythrocyte differentiation IDA
Inferred from Direct Assay
more info
 
positive regulation of erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of protein complex assembly IDA
Inferred from Direct Assay
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
 
regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of mast cell differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of stem cell maintenance IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 
spinal cord association neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
colocalizes_with Lsd1/2 complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with histone deacetylase complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
T-cell acute lymphocytic leukemia protein 1
Names
T-cell acute lymphocytic leukemia protein 1
tal-1 product
stem cell protein
T-cell leukemia/lymphoma protein 5
class A basic helix-loop-helix protein 17

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287347.2NP_001274276.1  T-cell acute lymphocytic leukemia protein 1 isoform 1

    See proteins identical to NP_001274276.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
    Source sequence(s)
    AL135960, BQ186967, KF495937, S53245
    Consensus CDS
    CCDS547.1
    UniProtKB/Swiss-Prot
    P17542
    UniProtKB/TrEMBL
    Q16509
    Related
    ENSP00000360951, OTTHUMP00000009563, ENST00000371884, OTTHUMT00000021639
    Conserved Domains (1) summary
    cd00083
    Location:185243
    Blast Score: 189
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  2. NM_001290403.1NP_001277332.1  T-cell acute lymphocytic leukemia protein 1 isoform 1

    See proteins identical to NP_001277332.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
    Source sequence(s)
    AL135960, BQ186967, M61108
    Consensus CDS
    CCDS547.1
    UniProtKB/Swiss-Prot
    P17542
    Conserved Domains (1) summary
    cd00083
    Location:185243
    Blast Score: 189
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  3. NM_001290404.1NP_001277333.1  T-cell acute lymphocytic leukemia protein 1 isoform 1

    See proteins identical to NP_001277333.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
    Source sequence(s)
    AL135960, BQ186967, M61108
    UniProtKB/Swiss-Prot
    P17542
    Conserved Domains (1) summary
    cd00083
    Location:185243
    Blast Score: 189
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  4. NM_001290405.1NP_001277334.1  T-cell acute lymphocytic leukemia protein 1 isoform 1

    See proteins identical to NP_001277334.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
    Source sequence(s)
    AL135960, BQ186967, M61108
    UniProtKB/Swiss-Prot
    P17542
    Conserved Domains (1) summary
    cd00083
    Location:185243
    Blast Score: 189
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  5. NM_001290406.1NP_001277335.1  T-cell acute lymphocytic leukemia protein 1 isoform 2

    See proteins identical to NP_001277335.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks three consecutive internal exons in the 5' region and uses a downstream translation start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL135960, BQ186967, M61108, S53678
    UniProtKB/Swiss-Prot
    P17542
    Conserved Domains (1) summary
    cd00083
    Location:2684
    Blast Score: 184
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  6. NM_003189.5NP_003180.1  T-cell acute lymphocytic leukemia protein 1 isoform 1

    See proteins identical to NP_003180.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
    Source sequence(s)
    AL135960, BQ186967, M61108
    Consensus CDS
    CCDS547.1
    UniProtKB/Swiss-Prot
    P17542
    Related
    ENSP00000294339, OTTHUMP00000009564, ENST00000294339, OTTHUMT00000021640
    Conserved Domains (1) summary
    cd00083
    Location:185243
    Blast Score: 189
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    47216290..47232266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271158.2XP_005271215.1  

    Conserved Domains (1) summary
    cd00083
    Location:185243
    Blast Score: 189
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  2. XM_006710863.1XP_006710926.1  

    See proteins identical to XP_006710926.1

    Conserved Domains (1) summary
    cd00083
    Location:2684
    Blast Score: 184
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  3. XM_005271159.2XP_005271216.1  

    See proteins identical to XP_005271216.1

    UniProtKB/Swiss-Prot
    P17542
    Conserved Domains (1) summary
    cd00083
    Location:185243
    Blast Score: 189
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  4. XM_006710862.1XP_006710925.1  

    See proteins identical to XP_006710925.1

    UniProtKB/Swiss-Prot
    P17542
    Conserved Domains (1) summary
    cd00083
    Location:185243
    Blast Score: 189
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
  5. XM_005271160.2XP_005271217.1  

    See proteins identical to XP_005271217.1

    UniProtKB/Swiss-Prot
    P17542
    Conserved Domains (1) summary
    cd00083
    Location:185243
    Blast Score: 189
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    45798599..45814018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    47798844..47814263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)