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    Adar adenosine deaminase, RNA-specific [ Mus musculus (house mouse) ]

    Gene ID: 56417, updated on 8-Aug-2015
    Official Symbol
    Adarprovided by MGI
    Official Full Name
    adenosine deaminase, RNA-specificprovided by MGI
    Primary source
    MGI:MGI:1889575
    See related
    Ensembl:ENSMUSG00000027951; Vega:OTTMUSG00000020280
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adar1; mZaADAR; AV242451; Adar1p110; Adar1p150
    Orthologs
    See Adar in Epigenomics, MapViewer
    Location:
    3; 3 F2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 3 NC_000069.6 (89715022..89753455)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (89518944..89557377)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene phosphomevalonate kinase Neighboring gene potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 Neighboring gene RIKEN cDNA 4632404H12 gene Neighboring gene cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) Neighboring gene ubiquitin-conjugating enzyme E2Q (putative) 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • C6 deamination of adenosine, organism-specific biosystem (from REACTOME)
      C6 deamination of adenosine, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cytosolic DNA-sensing pathway, organism-specific biosystem (from KEGG)
      Cytosolic DNA-sensing pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
    • Cytosolic DNA-sensing pathway, conserved biosystem (from KEGG)
      Cytosolic DNA-sensing pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
    • Formation of editosomes by ADAR proteins, organism-specific biosystem (from REACTOME)
      Formation of editosomes by ADAR proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • mRNA Editing, organism-specific biosystem (from REACTOME)
      mRNA Editing, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • mRNA Editing: A to I Conversion, organism-specific biosystem (from REACTOME)
      mRNA Editing: A to I Conversion, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    double-stranded RNA adenosine deaminase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded RNA adenosine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    left-handed Z-DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A) RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    adenosine to inosine editing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenosine to inosine editing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adenosine to inosine editing ISO
    Inferred from Sequence Orthology
    more info
     
    base conversion or substitution editing ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    definitive hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
     
    hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    miRNA loading onto RISC involved in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of RNA interference IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein kinase activity by regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein kinase activity by regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of type I interferon-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    pre-miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    production of miRNAs involved in gene silencing by miRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to interferon-alpha ISO
    Inferred from Sequence Orthology
    more info
     
    response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    somatic diversification of immune receptors via somatic mutation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    supraspliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    double-stranded RNA-specific adenosine deaminase
    Names
    DRADA
    RNA adenosine deaminase 1
    RNA-specific adenosine deaminase p110 form
    RNA-specific adenosine deaminase p150 form
    NP_001033676.2
    NP_001139768.1
    NP_062629.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038587.4NP_001033676.2  double-stranded RNA-specific adenosine deaminase isoform 2

      See identical proteins and their annotated locations for NP_001033676.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different first exon, which results in the use of a downstream start codon, compared to variant 3. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 3.
      Source sequence(s)
      AK076413, AK147614, BP758811, CJ180874
      Consensus CDS
      CCDS17514.1
      UniProtKB/TrEMBL
      Q3UH31
      Related
      ENSMUSP00000096525, OTTMUSP00000021979, ENSMUST00000098924, OTTMUST00000048136
      Conserved Domains (3) summary
      smart00550
      Location:164
      Zalpha; Z-DNA-binding domain in adenosine deaminases
      smart00552
      Location:540923
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd00048
      Location:208274
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    2. NM_001146296.1NP_001139768.1  double-stranded RNA-specific adenosine deaminase isoform 3

      See identical proteins and their annotated locations for NP_001139768.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest protein (isoform 3).
      Source sequence(s)
      AF291050, AK089451, AK147614, BP758811, BY776547
      Consensus CDS
      CCDS50963.1
      UniProtKB/TrEMBL
      Q3UH31
      UniProtKB/Swiss-Prot
      Q99MU3
      Related
      ENSMUSP00000103028, OTTMUSP00000021977, ENSMUST00000107405, OTTMUST00000048132
      Conserved Domains (4) summary
      smart00550
      Location:246312
      Zalpha; Z-DNA-binding domain in adenosine deaminases
      smart00552
      Location:7881171
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd00048
      Location:456522
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam02295
      Location:142203
      z-alpha; Adenosine deaminase z-alpha domain
    3. NM_019655.3NP_062629.3  double-stranded RNA-specific adenosine deaminase isoform 1

      See identical proteins and their annotated locations for NP_062629.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses a different splice site, compared to variant 3. The resulting protein (isoform 1) is shorter when it is compared to isoform 3.
      Source sequence(s)
      AF291050, AK089451, AK147614, BP758811, BY776547
      Consensus CDS
      CCDS17513.1
      UniProtKB/TrEMBL
      Q3UH31
      UniProtKB/Swiss-Prot
      Q99MU3
      Conserved Domains (4) summary
      smart00550
      Location:246312
      Zalpha; Z-DNA-binding domain in adenosine deaminases
      smart00552
      Location:7621145
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd00048
      Location:456522
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam02295
      Location:142203
      z-alpha; Adenosine deaminase z-alpha domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p3 C57BL/6J

      Range
      89715022..89753455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501753.2XP_006501816.2  

      Conserved Domains (4) summary
      smart00550
      Location:285351
      Zalpha; Z-DNA-binding domain in adenosine deaminases
      smart00552
      Location:8011184
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd00048
      Location:495561
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam02295
      Location:181242
      z-alpha; Adenosine deaminase z-alpha domain
    2. XM_006501752.2XP_006501815.2  

      Conserved Domains (4) summary
      smart00550
      Location:285351
      Zalpha; Z-DNA-binding domain in adenosine deaminases
      smart00552
      Location:8271210
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd00048
      Location:495561
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      pfam02295
      Location:181242
      z-alpha; Adenosine deaminase z-alpha domain
    3. XM_006501754.2XP_006501817.1  

      See identical proteins and their annotated locations for XP_006501817.1

      UniProtKB/Swiss-Prot
      Q99MU3
      Conserved Domains (3) summary
      smart00550
      Location:164
      Zalpha; Z-DNA-binding domain in adenosine deaminases
      smart00552
      Location:540923
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      cd00048
      Location:208274
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

    Alternate Mm_Celera

    Genomic

    1. AC_000025.1 Alternate Mm_Celera

      Range
      89752022..89790497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)