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UGT2A1 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus [ Homo sapiens (human) ]

Gene ID: 10941, updated on 24-Aug-2014
Official Symbol
UGT2A1provided by HGNC
Official Full Name
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locusprovided by HGNC
Primary source
HGNC:12542
See related
Ensembl:ENSG00000173610; HPRD:05279; MIM:604716; Vega:OTTHUMG00000184942
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UDPGT2A1
Summary
The protein encoded by this gene belongs to the UDP-glycosyltransferase family, members of which catalyze biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This enzyme is expressed in the olfactory neuroepithelium, which lines the posterior nasal cavity and is exposed to a wide range of odorants and airborne toxic compounds. Hence, this protein has been suggested to be involved in clearing lipophilic odorant molecules from the sensory epithelium. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. This gene shares exon structure with the UDP glucuronosyltransferase 2A2 family member, which encodes N-terminally distinct isoforms. [provided by RefSeq, Jul 2014]
See UGT2A1 in Epigenomics, MapViewer
Location:
4q13
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 4 NC_000004.12 (69588417..69653249, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70454135..70518967, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase 2 family, polypeptide B4 Neighboring gene UDP glucuronosyltransferase 2 family, polypeptide A3 pseudogene 7 Neighboring gene UDP glucuronosyltransferase 2 family, polypeptide B7 pseudogene Neighboring gene UDP glucuronosyltransferase 2 family, polypeptide A2 Neighboring gene sulfotransferase family, cytosolic, 1B, member 1 Neighboring gene sulfotransferase family, cytosolic, 1D, member 1, pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glucuronosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
glucuronosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular glucuronidation IDA
Inferred from Direct Assay
more info
PubMed 
detection of chemical stimulus TAS
Traceable Author Statement
more info
PubMed 
metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
metabolic process TAS
Traceable Author Statement
more info
PubMed 
sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
UDP-glucuronosyltransferase 2A1
Names
UDP-glucuronosyltransferase 2A1
UDP glycosyltransferase 2 family, polypeptide A1
uridine diphosphate glycosyltransferase 2 family, member A1
NP_001239203.1
NP_001239204.1
NP_006789.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252274.2NP_001239203.2  UDP-glucuronosyltransferase 2A1 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    AK304249, AK314209, BC142640, BE463677
    Consensus CDS
    CCDS58902.1
    Conserved Domains (2) summary
    cd03784
    Location:252612
    Blast Score: 286
    GT1_Gtf_like; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the ...
    pfam00201
    Location:237681
    Blast Score: 1676
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
  2. NM_001252275.2NP_001239204.2  UDP-glucuronosyltransferase 2A1 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon but instead contains a different in-frame exon in the central coding region, compared to variant 2. The encoded isoform (3) is shorter than isoform 2.
    Source sequence(s)
    AK304249, AK314209, BC142640, BE463677
    Consensus CDS
    CCDS58901.1
    Conserved Domains (2) summary
    pfam00201
    Location:21515
    Blast Score: 1663
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
    cl10013
    Location:42446
    Blast Score: 254
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
  3. NM_001301239.1NP_001288168.1  UDP-glucuronosyltransferase 2A1 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as UGT2A1deltaexon3) differs in the 5' UTR, and lacks an alternate in-frame exon in both the central and 3' coding regions, compared to variant 2. The encoded isoform (4, also known as UGT2A1_i2) is shorter than isoform 2.
    Source sequence(s)
    AC093829, AK304249, BC142640, BE463677
    Conserved Domains (2) summary
    pfam00201
    Location:21471
    Blast Score: 1722
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
    cl10013
    Location:295402
    Blast Score: 251
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...
  4. NM_006798.4NP_006789.3  UDP-glucuronosyltransferase 2A1 isoform 1 precursor

    See proteins identical to NP_006789.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon in the central coding region, but contains an additional in-frame exon in the 3' coding region, compared to variant 2. The encoded isoform (1, also known as UGT2A1_i1) is shorter than isoform 2.
    Source sequence(s)
    AJ006054, AK304249, AK314209, BC142640, BE463677
    Consensus CDS
    CCDS3529.1
    Related
    ENSP00000387888, ENST00000457664
    Conserved Domains (2) summary
    cd03784
    Location:42446
    Blast Score: 337
    GT1_Gtf_like; This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the ...
    pfam00201
    Location:21515
    Blast Score: 1999
    UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000004.12 

    Range
    69588417..69653249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000136.1 

    Range
    66252679..66316832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 

    Range
    70490004..70554806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)