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    Aqp4 aquaporin 4 [ Mus musculus (house mouse) ]

    Gene ID: 11829, updated on 26-Jul-2015
    Official Symbol
    Aqp4provided by MGI
    Official Full Name
    aquaporin 4provided by MGI
    Primary source
    MGI:MGI:107387
    See related
    Ensembl:ENSMUSG00000024411
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    WCH4
    Orthologs
    See Aqp4 in Epigenomics, MapViewer
    Location:
    18 A1; 18 8.74 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 18 NC_000084.6 (15389394..15410977, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (15547903..15562193, complement)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41672 Neighboring gene RIKEN cDNA A830021F12 gene Neighboring gene predicted gene, 30230 Neighboring gene fibrillarin pseudogene Neighboring gene carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 Neighboring gene predicted gene, 30452

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    glycerol channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    porin activity ISO
    Inferred from Sequence Orthology
    more info
     
    transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    water channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    water channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    carbohydrate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    carbon dioxide transport ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to interferon-gamma ISO
    Inferred from Sequence Orthology
    more info
     
    cellular water homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    glycerol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of cell adhesion molecule production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    renal water absorption IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    renal water absorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    water homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    water homeostasis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    water transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    water transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    water transport ISO
    Inferred from Sequence Orthology
    more info
     
    water transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell projection membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    aquaporin-4
    Names
    mercurial-insensitive water channel

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308641.1NP_001295570.1  aquaporin-4 isoform M23A

      See identical proteins and their annotated locations for NP_001295570.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, also known as a/1) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (M23A) has a shorter N-terminus than isoform M1. Variants 2, 3, 4, 5, 6, 7, and 8 encode the same isoform (M23A).
      Source sequence(s)
      AC133525
      Conserved Domains (1) summary
      cd00333
      Location:14229
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    2. NM_001308642.1NP_001295571.1  aquaporin-4 isoform M23A

      See identical proteins and their annotated locations for NP_001295571.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3, also known as ad/1) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (M23A) has a shorter N-terminus than isoform M1. Variants 2, 3, 4, 5, 6, 7, and 8 encode the same isoform (M23A).
      Source sequence(s)
      AC133525
      Conserved Domains (1) summary
      cd00333
      Location:14229
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    3. NM_001308643.1NP_001295572.1  aquaporin-4 isoform M23A

      See identical proteins and their annotated locations for NP_001295572.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4, also known as ab/1) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (M23A) has a shorter N-terminus than isoform M1. Variants 2, 3, 4, 5, 6, 7, and 8 encode the same isoform (M23A).
      Source sequence(s)
      AC133525
      Conserved Domains (1) summary
      cd00333
      Location:14229
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    4. NM_001308644.1NP_001295573.1  aquaporin-4 isoform M23A

      See identical proteins and their annotated locations for NP_001295573.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5, also known as ac/1) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (M23A) has a shorter N-terminus than isoform M1. Variants 2, 3, 4, 5, 6, 7, and 8 encode the same isoform (M23A).
      Source sequence(s)
      AC133525
      Conserved Domains (1) summary
      cd00333
      Location:14229
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    5. NM_001308645.1NP_001295574.1  aquaporin-4 isoform M23A

      See identical proteins and their annotated locations for NP_001295574.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6, also known as abc/1) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (M23A) has a shorter N-terminus than isoform M1. Variants 2, 3, 4, 5, 6, 7, and 8 encode the same isoform (M23A).
      Source sequence(s)
      AC133525
      Conserved Domains (1) summary
      cd00333
      Location:14229
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    6. NM_001308646.1NP_001295575.1  aquaporin-4 isoform M23A

      See identical proteins and their annotated locations for NP_001295575.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7, also known as abcd/1) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (M23A) has a shorter N-terminus than isoform M1. Variants 2, 3, 4, 5, 6, 7, and 8 encode the same isoform (M23A).
      Source sequence(s)
      AC133525
      Conserved Domains (1) summary
      cd00333
      Location:14229
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    7. NM_001308647.1NP_001295576.1  aquaporin-4 isoform M23A

      See identical proteins and their annotated locations for NP_001295576.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (M23A, also known as M23X) has a shorter N-terminus than isoform M1. Variants 2, 3, 4, 5, 6, 7, and 8 encode the same isoform (M23A).
      Source sequence(s)
      AC133525, AK039777, AK045357, CD803766
      Conserved Domains (1) summary
      cd00333
      Location:14229
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    8. NM_009700.2NP_033830.2  aquaporin-4 isoform M1

      See identical proteins and their annotated locations for NP_033830.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (M1).
      Source sequence(s)
      AC133525, AK045357, BB628835, U88623
      Consensus CDS
      CCDS29073.1
      UniProtKB/Swiss-Prot
      P55088
      Related
      ENSMUSP00000078088, ENSMUST00000079081
      Conserved Domains (1) summary
      cd00333
      Location:36251
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p3 C57BL/6J

      Range
      15389394..15410977
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246817.1XP_011245119.1  

      Conserved Domains (1) summary
      cd00333
      Location:14229
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    2. XM_011246816.1XP_011245118.1  

      Conserved Domains (1) summary
      cd00333
      Location:14229
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    3. XM_011246815.1XP_011245117.1  

      Conserved Domains (1) summary
      cd00333
      Location:14229
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    4. XM_011246813.1XP_011245115.1  

      Conserved Domains (1) summary
      cd00333
      Location:14229
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    5. XM_011246812.1XP_011245114.1  

      Conserved Domains (1) summary
      cd00333
      Location:14229
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    6. XM_011246814.1XP_011245116.1  

      See identical proteins and their annotated locations for XP_011245116.1

      UniProtKB/Swiss-Prot
      P55088
      UniProtKB/TrEMBL
      Q50H70
      Conserved Domains (1) summary
      cd00333
      Location:14229
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
    7. XM_006525540.1XP_006525603.1  

      Conserved Domains (1) summary
      cd00333
      Location:14229
      MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

    Alternate Mm_Celera

    Genomic

    1. AC_000040.1 Alternate Mm_Celera

      Range
      15609213..15623487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)