Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Disc1 disrupted in schizophrenia 1 [ Mus musculus (house mouse) ]

    Gene ID: 244667, updated on 10-Sep-2016
    Official Symbol
    Disc1provided by MGI
    Official Full Name
    disrupted in schizophrenia 1provided by MGI
    Primary source
    MGI:MGI:2447658
    See related
    Ensembl:ENSMUSG00000043051 Vega:OTTMUSG00000032471
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Orthologs
    Location:
    8 E2; 8 73.26 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (125050766..125265143)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (127578095..127785051)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39281 Neighboring gene translin-associated factor X Neighboring gene predicted gene, 30713 Neighboring gene signal-induced proliferation-associated 1 like 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    kinesin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex scaffold IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation in forebrain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cerebral cortex radially oriented cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    neuron migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    nonmotile primary cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nonmotile primary cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    pyramidal neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synapse maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cell body ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ciliary base ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    dynein complex ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    kinesin complex ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    synapse IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    disrupted in schizophrenia 1 homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174853.2NP_777278.2  disrupted in schizophrenia 1 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AJ506179, AL672234, AL731650, AY177673
      Consensus CDS
      CCDS40517.1
      UniProtKB/Swiss-Prot
      Q811T9
      Related
      ENSMUSP00000075145, ENSMUST00000075730
      Conserved Domains (1) summary
      cd00890
      Location:455560
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
    2. NM_174854.2NP_777279.2  disrupted in schizophrenia 1 homolog isoform 1

      See identical proteins and their annotated locations for NP_777279.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AJ506179, AL672234, AL731650, AY177673
      Consensus CDS
      CCDS52707.1
      UniProtKB/Swiss-Prot
      Q811T9
      Related
      ENSMUSP00000095914, ENSMUST00000098311
      Conserved Domains (1) summary
      COG1196
      Location:329620
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      125050766..125265143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248388.2XP_011246690.1  

      See identical proteins and their annotated locations for XP_011246690.1

      UniProtKB/Swiss-Prot
      Q811T9
      Related
      ENSMUSP00000112410, OTTMUSP00000043041, ENSMUST00000118942, OTTMUST00000080764
      Conserved Domains (1) summary
      COG1196
      Location:329620
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    2. XM_017312834.1XP_017168323.1  

    3. XM_017312833.1XP_017168322.1  

    4. XM_011248387.2XP_011246689.1  

      Conserved Domains (1) summary
      pfam01920
      Location:470506
      Prefoldin_2; Prefoldin subunit

    RNA

    1. XR_001778440.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_170596.1: Suppressed sequence

      Description
      NM_170596.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Support Center