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    Stk11 serine/threonine kinase 11 [ Mus musculus (house mouse) ]

    Gene ID: 20869, updated on 25-Aug-2016
    Official Symbol
    Stk11provided by MGI
    Official Full Name
    serine/threonine kinase 11provided by MGI
    Primary source
    MGI:MGI:1341870
    See related
    Ensembl:ENSMUSG00000003068 Vega:OTTMUSG00000000002
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lkb1; Par-4; R75140; AA408040
    Summary
    This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014]
    Orthologs
    Location:
    10; 10 C1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (80115692..80130685)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (79579281..79593215)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene glutathione peroxidase 4 Neighboring gene strawberry notch homolog 2 (Drosophila) Neighboring gene uncharacterized LOC108167824 Neighboring gene calcium channel, voltage-dependent, beta subunit associated regulatory protein Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit Neighboring gene midnolin

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    LRR domain binding IPI
    Inferred from Physical Interaction
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Golgi localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T cell receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    TCR signalosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to UV-B IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to UV-B ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell proliferation involved in prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of lipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of axonogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive thymic T cell selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to ionizing radiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to lipid ISO
    Inferred from Sequence Orthology
    more info
     
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    tissue homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    TCR signalosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    serine/threonine-protein kinase STK11
    Names
    liver kinase B1 homolog
    serine/threonine-protein kinase 11
    serine/threonine-protein kinase LKB1
    stk11
    NP_001288782.1
    NP_001288783.1
    NP_035622.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301853.1NP_001288782.1  serine/threonine-protein kinase STK11 isoform S

      See identical proteins and their annotated locations for NP_001288782.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (S, see PMID:18774945) has a distinct C-terminus and is shorter than isoform L.
      Source sequence(s)
      AC159999, BC052379, BE951985, CO424479, EU730638
      Consensus CDS
      CCDS78854.1
      UniProtKB/Swiss-Prot
      Q9WTK7
      Related
      ENSMUSP00000114195, OTTMUSP00000043767, ENSMUST00000144883, OTTMUST00000045748
      Conserved Domains (2) summary
      smart00220
      Location:49309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14119
      Location:55309
      STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
    2. NM_001301854.1NP_001288783.1  serine/threonine-protein kinase STK11 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' terminal exon, and initiates translation at a downstream in-frame start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus, compared to isoform L.
      Source sequence(s)
      AC159999, AK004499, AK147802, BC052379, CJ229363
      UniProtKB/Swiss-Prot
      Q9WTK7
      UniProtKB/TrEMBL
      Q3V4A1
      Related
      ENSMUSP00000101009, OTTMUSP00000020600, ENSMUST00000105370, OTTMUST00000045749
      Conserved Domains (2) summary
      smart00220
      Location:1185
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1185
      PKc_like; Protein Kinases, catalytic domain
    3. NM_011492.4NP_035622.1  serine/threonine-protein kinase STK11 isoform L

      See identical proteins and their annotated locations for NP_035622.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (L, see PMID:18774945).
      Source sequence(s)
      AC159999, AK004499, BC052379, BE951985, CJ229363, CO424479
      Consensus CDS
      CCDS35974.1
      UniProtKB/Swiss-Prot
      Q9WTK7
      UniProtKB/TrEMBL
      Q3V4A1
      Related
      ENSMUSP00000003152, OTTMUSP00000020599, ENSMUST00000003152, OTTMUST00000045747
      Conserved Domains (2) summary
      smart00220
      Location:49309
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14119
      Location:55309
      STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1

    RNA

    1. NR_126043.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in the variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC159999, AK004499, BC052379, BE951985, BF468348, CD565465, CJ229363, CO424479, EU730638

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      80115692..80130685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513443.3XP_006513506.1  

      Conserved Domains (1) summary
      cl21453
      Location:55155
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006513441.3XP_006513504.1  

      Conserved Domains (2) summary
      smart00220
      Location:49245
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:55245
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006513442.3XP_006513505.1  

      Conserved Domains (1) summary
      cl21453
      Location:23132
      PKc_like; Protein Kinases, catalytic domain
    4. XM_006513439.3XP_006513502.1  

      Conserved Domains (2) summary
      smart00220
      Location:79291
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14119
      Location:79291
      STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1