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STX6 syntaxin 6 [ Homo sapiens (human) ]

Gene ID: 10228, updated on 7-Dec-2014
Official Symbol
STX6provided by HGNC
Official Full Name
syntaxin 6provided by HGNC
Primary source
HGNC:HGNC:11441
See related
Ensembl:ENSG00000135823; HPRD:07231; MIM:603944; Vega:OTTHUMG00000035179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
See STX6 in Epigenomics, MapViewer
Location:
1q25.3
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (180972712..181023121, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (180942164..180992074, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724791 Neighboring gene major histocompatibility complex, class I-related pseudogene Neighboring gene major histocompatibility complex, class I-related Neighboring gene immediate early response 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
syntaxin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi ribbon formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Golgi vesicle transport IEA
Inferred from Electronic Annotation
more info
 
endosome organization IEA
Inferred from Electronic Annotation
more info
 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
PubMed 
vesicle fusion IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
SNARE complex IDA
Inferred from Direct Assay
more info
PubMed 
clathrin-coated vesicle TAS
Traceable Author Statement
more info
PubMed 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
syntaxin-6
Names
syntaxin-6

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286210.1NP_001273139.1  syntaxin-6 isoform 2

    See proteins identical to NP_001273139.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks a portion of the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform (1).
    Source sequence(s)
    AK299063, AL162431, AL356267
    Consensus CDS
    CCDS65738.1
    UniProtKB/Swiss-Prot
    O43752
    Related
    ENSP00000440188, ENST00000542060
    Conserved Domains (1) summary
    cd00193
    Location:65124
    t_SNARE; Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in ...
  2. NM_005819.5NP_005810.1  syntaxin-6 isoform 1

    See proteins identical to NP_005810.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL162431, BC009944, DA311923
    Consensus CDS
    CCDS1341.1
    UniProtKB/Swiss-Prot
    O43752
    Related
    ENSP00000258301, OTTHUMP00000033134, ENST00000258301, OTTHUMT00000085143
    Conserved Domains (2) summary
    cd00193
    Location:166225
    t_SNARE; Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in ...
    pfam09177
    Location:5103
    Syntaxin-6_N; Syntaxin 6, N-terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    180972712..181023121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005244824.1XP_005244881.1  

    See proteins identical to XP_005244881.1

    UniProtKB/Swiss-Prot
    O43752
    Conserved Domains (1) summary
    cd00193
    Location:65124
    t_SNARE; Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in ...

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    182364522..182414928
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    152172704..152231058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)