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    Ryr2 ryanodine receptor 2, cardiac [ Mus musculus (house mouse) ]

    Gene ID: 20191, updated on 19-Jan-2016
    Official Symbol
    Ryr2provided by MGI
    Official Full Name
    ryanodine receptor 2, cardiacprovided by MGI
    Primary source
    MGI:MGI:99685
    See related
    Ensembl:ENSMUSG00000021313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RYR-2; 9330127I20Rik
    Orthologs
    See Ryr2 in Epigenomics, MapViewer
    Location:
    13 4.38 cM; 13 A1-A2
    Exon count:
    108
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 13 NC_000079.6 (11553099..12106945, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (11645370..12199212, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40666 Neighboring gene zona pellucida glycoprotein 4, pseudogene Neighboring gene ribosomal protein S7 pseudogene Neighboring gene predicted gene 10336 Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
      Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Cardiac conduction, organism-specific biosystem (from REACTOME)
      Cardiac conduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
      Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Cardiac muscle contraction, conserved biosystem (from KEGG)
      Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Circadian entrainment, organism-specific biosystem (from KEGG)
      Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
    • Circadian entrainment, conserved biosystem (from KEGG)
      Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
    • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
      Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Dilated cardiomyopathy, conserved biosystem (from KEGG)
      Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Insulin secretion, organism-specific biosystem (from KEGG)
      Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
    • Ion channel transport, organism-specific biosystem (from REACTOME)
      Ion channel transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Ion homeostasis, organism-specific biosystem (from REACTOME)
      Ion homeostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystem
      Myometrial Relaxation and Contraction Pathways
    • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
      Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
    • Oxytocin signaling pathway, conserved biosystem (from KEGG)
      Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
    • Pancreatic secretion, organism-specific biosystem (from KEGG)
      Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Pancreatic secretion, conserved biosystem (from KEGG)
      Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
      SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
    • Stimuli-sensing channels, organism-specific biosystem (from REACTOME)
      Stimuli-sensing channels, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-induced calcium release activity ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    calmodulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular ligand-gated calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    organic cyclic compound binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase A catalytic subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase A regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein self-association IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ryanodine-sensitive calcium-release channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ryanodine-sensitive calcium-release channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    suramin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Purkinje myocyte to ventricular cardiac muscle cell signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium ion transport IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion transport into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcium-mediated signaling using intracellular calcium source ISO
    Inferred from Sequence Orthology
    more info
     
    canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    cardiac muscle hypertrophy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to caffeine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to caffeine ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to epinephrine stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytosolic calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    detection of calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic heart tube morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of protein localization to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    left ventricular cardiac muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    manganese ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organismal development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcium-transporting ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of sequestering of calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of the force of heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of AV node cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of SA node cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of atrial cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cardiac muscle contraction by calcium ion signaling ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of ventricular cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
     
    release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    response to caffeine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to caffeine ISO
    Inferred from Sequence Orthology
    more info
     
    response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
     
    response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to magnesium ion ISO
    Inferred from Sequence Orthology
    more info
     
    response to muscle activity ISO
    Inferred from Sequence Orthology
    more info
     
    response to muscle stretch ISO
    Inferred from Sequence Orthology
    more info
     
    response to redox state ISO
    Inferred from Sequence Orthology
    more info
     
    sarcoplasmic reticulum calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    type B pancreatic cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    type B pancreatic cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    ventricular cardiac muscle cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    A band ISO
    Inferred from Sequence Orthology
    more info
     
    Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    calcium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IC
    Inferred by Curator
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    sarcomere IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sarcoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    sarcoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sarcoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    smooth endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    ryanodine receptor 2
    Names
    calcium release channel
    cardiac muscle ryanodine receptor
    cardiac muscle ryanodine receptor-calcium release channel
    ryanodine receptor type 2
    type 2 ryanodine receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023868.2NP_076357.2  ryanodine receptor 2

      See identical proteins and their annotated locations for NP_076357.2

      Status: VALIDATED

      Source sequence(s)
      AC131329, AC159208, AF295105, BB387101, BC059061, BU921357, U23755
      Consensus CDS
      CCDS49206.1
      UniProtKB/Swiss-Prot
      E9Q401
      UniProtKB/TrEMBL
      Q60835
      UniProtKB/TrEMBL
      Q80ZZ5
      Related
      ENSMUSP00000021750, ENSMUST00000021750
      Conserved Domains (14) summary
      smart00472
      Location:286376
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:654805
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:10861218
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      cd12879
      Location:14121559
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      pfam00520
      Location:47114829
      Ion_trans; Ion transport protein
      pfam01365
      Location:451655
      RYDR_ITPR; RIH domain
      pfam02026
      Location:26992793
      RyR; RyR domain
      pfam02815
      Location:226406
      MIR; MIR domain
      pfam06459
      Location:43324598
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:38253947
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:9219
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
      pfam13499
      Location:40324086
      EF-hand_7; EF-hand domain pair
      pfam14070
      Location:39544003
      YjfB_motility; Putative motility protein
      cl08302
      Location:40294084
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p3 C57BL/6J

      Range
      11553099..12106945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244296.1XP_011242598.1  

      Conserved Domains (14) summary
      smart00472
      Location:279369
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:647798
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:10791211
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      cd12879
      Location:14051552
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      pfam00520
      Location:46924810
      Ion_trans; Ion transport protein
      pfam01365
      Location:444648
      RYDR_ITPR; RIH domain
      pfam02026
      Location:26922786
      RyR; RyR domain
      pfam02815
      Location:219399
      MIR; MIR domain
      pfam06459
      Location:43134579
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:38063928
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:9212
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
      pfam13499
      Location:40134067
      EF-hand_7; EF-hand domain pair
      pfam14070
      Location:39353984
      YjfB_motility; Putative motility protein
      cl08302
      Location:40104065
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    2. XM_006516610.1XP_006516673.1  

      Conserved Domains (14) summary
      smart00472
      Location:286376
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:654805
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:10861218
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      cd12879
      Location:14121559
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      pfam00520
      Location:47304848
      Ion_trans; Ion transport protein
      pfam01365
      Location:451655
      RYDR_ITPR; RIH domain
      pfam02026
      Location:26992793
      RyR; RyR domain
      pfam02815
      Location:226406
      MIR; MIR domain
      pfam06459
      Location:43514617
      RR_TM4-6; Ryanodine Receptor TM 4-6
      pfam08454
      Location:38443966
      RIH_assoc; RyR and IP3R Homology associated
      pfam08709
      Location:9219
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
      pfam13499
      Location:40514105
      EF-hand_7; EF-hand domain pair
      pfam14070
      Location:39734022
      YjfB_motility; Putative motility protein
      cl08302
      Location:40484103
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    3. XM_006516614.2XP_006516677.1  

      Conserved Domains (8) summary
      smart00472
      Location:286376
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:654805
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:10861218
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      cd12879
      Location:14121559
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      pfam01365
      Location:451655
      RYDR_ITPR; RIH domain
      pfam02026
      Location:26992793
      RyR; RyR domain
      pfam02815
      Location:226406
      MIR; MIR domain
      pfam08709
      Location:9219
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    4. XM_011244297.1XP_011242599.1  

      Conserved Domains (8) summary
      smart00472
      Location:286376
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:654805
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:10861218
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      cd12879
      Location:14121559
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      pfam01365
      Location:451655
      RYDR_ITPR; RIH domain
      pfam02026
      Location:26992793
      RyR; RyR domain
      pfam02815
      Location:226406
      MIR; MIR domain
      pfam08709
      Location:9219
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
    5. XM_006516615.2XP_006516678.1  

      Conserved Domains (8) summary
      smart00472
      Location:286376
      MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
      cd12877
      Location:654805
      SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)
      cd12878
      Location:10861218
      SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)
      cd12879
      Location:14121559
      SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)
      pfam01365
      Location:451655
      RYDR_ITPR; RIH domain
      pfam02026
      Location:26992793
      RyR; RyR domain
      pfam02815
      Location:226406
      MIR; MIR domain
      pfam08709
      Location:9219
      Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

    Alternate Mm_Celera

    Genomic

    1. AC_000035.1 Alternate Mm_Celera

      Range
      11467020..12025871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)