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CALCA calcitonin-related polypeptide alpha [ Homo sapiens (human) ]

Gene ID: 796, updated on 19-Apr-2015
Official Symbol
CALCAprovided by HGNC
Official Full Name
calcitonin-related polypeptide alphaprovided by HGNC
Primary source
HGNC:HGNC:1437
See related
Ensembl:ENSG00000110680; HPRD:00238; MIM:114130; Vega:OTTHUMG00000159731
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT; KC; CGRP; CALC1; CGRP1; CGRP-I
Summary
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
Orthologs
See CALCA in MapViewer
Location:
11p15.2
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (14966669..14972286, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (14988214..14993879, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily R, polypeptide 1 Neighboring gene uncharacterized LOC105376565 Neighboring gene calcitonin pseudogene Neighboring gene olfactory receptor, family 7, subfamily E, member 41 pseudogene Neighboring gene calcitonin-related polypeptide beta

Related articles in PubMed

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    Amyloids, organism-specific biosystemAmyloid is a term used to describe typically extracellular deposits of aggregated proteins, sometimes known as plaques. Abnormal accumulation of amyloid is amyloidosis, a term associated with disease...
  • Calcitonin-like ligand receptors, organism-specific biosystem (from REACTOME)
    Calcitonin-like ligand receptors, organism-specific biosystemThe calcitonin peptide family comprises calcitonin, amylin, calcitonin gene-related peptide (CGRP), adrenomedullin (AM) and intermedin (AM2). Calcitonin is a 32 amino acid peptide, involved in bone h...
  • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
    Class B/2 (Secretin family receptors), organism-specific biosystemThis family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptide...
  • Disease, organism-specific biosystem (from REACTOME)
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC126648

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcitonin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
hormone activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
activation of adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
aging IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cellular response to nerve growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
cytosolic calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
detection of temperature stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
embryo implantation IDA
Inferred from Direct Assay
more info
PubMed 
endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
feeding behavior IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
leukocyte cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
monocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of bone resorption IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of calcium ion transport into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neurological system process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of ossification IEA
Inferred from Electronic Annotation
more info
 
negative regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
neurological system process involved in regulation of systemic arterial blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of adenylate cyclase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cAMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-1 alpha production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of macrophage differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ossification IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vasodilation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of blood pressure NAS
Non-traceable Author Statement
more info
PubMed 
regulation of heart rate IEA
Inferred from Electronic Annotation
more info
 
regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
response to heat IEA
Inferred from Electronic Annotation
more info
 
response to pain IEA
Inferred from Electronic Annotation
more info
 
vasculature development IDA
Inferred from Direct Assay
more info
PubMed 
vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
terminal bouton IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
calcitonin; calcitonin gene-related peptide 1
Names
calcitonin
alpha-type CGRP
calcitonin 1
calcitonin gene-related peptide I
calcitonin/calcitonin-related polypeptide, alpha
katacalcin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015960.1 RefSeqGene

    Range
    5001..10618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_13

mRNA and Protein(s)

  1. NM_001033952.2NP_001029124.1  calcitonin isoform CT preproprotein

    See identical proteins and their annotated locations for NP_001029124.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate 3' coding region and 3' UTR compared to variant 3. The resulting protein has a longer and distinct C-terminus compared to calcitonin gene-related peptide 1. Variants 1 and 2 encode the same protein, which is cleaved to yield calcitonin (CT), a thyroid peptide-hormone product, and katacalcin peptides.
    Source sequence(s)
    AC090835, BF942024, M26095
    Consensus CDS
    CCDS7819.1
    UniProtKB/Swiss-Prot
    P01258
    Conserved Domains (2) summary
    smart00113
    Location:83120
    CALCITONIN; calcitonin
    pfam00214
    Location:1121
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
  2. NM_001033953.2NP_001029125.1  calcitonin gene-related peptide 1 isoform alpha-CGRP preproprotein

    See identical proteins and their annotated locations for NP_001029125.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest coding transcript and encodes the shorter protein, which is cleaved to yield calcitonin gene-related peptide 1 (alpha-CGRP). Alpha-CGRP functions both as an antimicrobial peptide and a vasodilator.
    Source sequence(s)
    AC090835, CD612754, FO082042
    Consensus CDS
    CCDS31432.1
    UniProtKB/Swiss-Prot
    P06881
    Related
    ENSP00000354286, ENST00000361010
    Conserved Domains (2) summary
    smart00113
    Location:81123
    CALCITONIN; calcitonin
    pfam00214
    Location:1126
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
  3. NM_001741.2NP_001732.1  calcitonin isoform CT preproprotein

    See identical proteins and their annotated locations for NP_001732.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' and 3' UTRs and the coding region compared to variant 3. The resulting protein has a longer and distinct C-terminus compared to calcitonin gene-related peptide 1. Variants 1 and 2 encode the same protein, which is cleaved to yield calcitonin (CT), a thyroid peptide-hormone product, and katacalcin peptides.
    Source sequence(s)
    BC069704, BF942024
    Consensus CDS
    CCDS7819.1
    UniProtKB/Swiss-Prot
    P01258
    Related
    ENSP00000331746, OTTHUMP00000216318, ENST00000331587, OTTHUMT00000357065
    Conserved Domains (2) summary
    smart00113
    Location:83120
    CALCITONIN; calcitonin
    pfam00214
    Location:1121
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

RNA

  1. NR_125898.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC069684, BX094781, CB048118, M64486

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    14966669..14972286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    14987226..14992843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)