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Lep leptin [ Rattus norvegicus (Norway rat) ]

Gene ID: 25608, updated on 5-Apr-2015
Official Symbol
Lepprovided by RGD
Official Full Name
leptinprovided by RGD
Primary source
RGD:3000
See related
Ensembl:ENSRNOG00000045797
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
OB; obese
Summary
involved in regulation of body weight, and may have a role in angiogenesis [RGD, Feb 2006]
Orthologs
See Lep in MapViewer
Location:
4q22
Exon count:
3
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (56337695..56351818)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (56085079..56099209)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene staphylococcal nuclease and tudor domain containing 1 Neighboring gene leucine rich repeat containing 4 Neighboring gene microRNA 129-1 Neighboring gene RNA binding motif protein 28 Neighboring gene proline-rich transmembrane protein 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cytokine activity TAS
Traceable Author Statement
more info
PubMed 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
peptide hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
JAK-STAT cascade TAS
Traceable Author Statement
more info
PubMed 
adipose tissue development IEA
Inferred from Electronic Annotation
more info
 
adipose tissue development ISO
Inferred from Sequence Orthology
more info
 
adult feeding behavior ISO
Inferred from Sequence Orthology
more info
 
adult feeding behavior ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
bile acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
bile acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
bone mineralization involved in bone maturation IDA
Inferred from Direct Assay
more info
PubMed 
cAMP-mediated signaling TAS
Traceable Author Statement
more info
PubMed 
cardiac muscle hypertrophy IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to L-ascorbic acid IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
central nervous system neuron development IEA
Inferred from Electronic Annotation
more info
 
central nervous system neuron development ISO
Inferred from Sequence Orthology
more info
 
cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
eating behavior IEA
Inferred from Electronic Annotation
more info
 
eating behavior ISO
Inferred from Sequence Orthology
more info
 
energy reserve metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 
fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
fatty acid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
glycerol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
hormone metabolic process IEA
Inferred from Electronic Annotation
more info
 
hormone metabolic process ISO
Inferred from Sequence Orthology
more info
 
insulin secretion IEA
Inferred from Electronic Annotation
more info
 
insulin secretion ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
leptin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte tethering or rolling IDA
Inferred from Direct Assay
more info
PubMed 
lipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of appetite ISO
Inferred from Sequence Orthology
more info
 
negative regulation of appetite ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of cartilage development IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of glucagon secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glucagon secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glutamine transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vasoconstriction IDA
Inferred from Direct Assay
more info
PubMed 
ovulation from ovarian follicle IDA
Inferred from Direct Assay
more info
PubMed 
placenta development IEA
Inferred from Electronic Annotation
more info
 
placenta development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of JAK-STAT cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JAK-STAT cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of STAT protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of STAT protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytokine production IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of developmental growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of developmental growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of follicle-stimulating hormone secretion IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of hepatic stellate cell activation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ion transport IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of luteinizing hormone secretion IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of myeloid cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peroxisome proliferator activated receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tyrosine phosphorylation of Stat3 protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
regulation of intestinal cholesterol absorption IEA
Inferred from Electronic Annotation
more info
 
regulation of intestinal cholesterol absorption ISO
Inferred from Sequence Orthology
more info
 
regulation of lipoprotein lipid oxidation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
response to dietary excess IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to dietary excess ISO
Inferred from Sequence Orthology
more info
 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
response to insulin ISO
Inferred from Sequence Orthology
more info
 
response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
response to vitamin E IEP
Inferred from Expression Pattern
more info
PubMed 
tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 
tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
leptin
Names
leptin
obesity factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013076.3NP_037208.1  leptin precursor

    See proteins identical to NP_037208.1

    Status: VALIDATED

    Source sequence(s)
    AC096035
    UniProtKB/Swiss-Prot
    P50596
    Related
    ENSRNOP00000066184, ENSRNOT00000071926
    Conserved Domains (1) summary
    pfam02024
    Location:22167
    Leptin; Leptin

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    56337695..56351818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762762.1XP_008760984.1  

    See proteins identical to XP_008760984.1

    UniProtKB/Swiss-Prot
    P50596
    Conserved Domains (1) summary
    pfam02024
    Location:22167
    Leptin; Leptin

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    52770132..52784148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)