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SOD1 superoxide dismutase SOD1 [ Saccharomyces cerevisiae S288c ]

Gene ID: 853568, updated on 22-Jul-2014
Gene symbol
SOD1
Gene description
superoxide dismutase SOD1
Primary source
SGD:S000003865
Locus tag
YJR104C
Gene type
protein coding
RNA name
superoxide dismutase SOD1
RefSeq status
PROVISIONAL
Organism
Saccharomyces cerevisiae S288c (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CRS4
See SOD1 in MapViewer
Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (622550..623014, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Vps25p Neighboring gene CTP synthase URA8 Neighboring gene adenosine kinase Neighboring gene Ecm27p

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
superoxide dismutase activity IDA
Inferred from Direct Assay
more info
PubMed 
superoxide dismutase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
age-dependent response to reactive oxygen species involved in chronological cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular copper ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular zinc ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of cellular respiration IMP
Inferred from Mutant Phenotype
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of sequence-specific DNA binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
 
protein stabilization IPI
Inferred from Physical Interaction
more info
 
removal of superoxide radicals IBA
Inferred from Biological aspect of Ancestor
more info
 
superoxide metabolic process IEA
Inferred from Electronic Annotation
more info
 
superoxide metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Names
superoxide dismutase SOD1
NP_012638.1
  • Cytosolic copper-zinc superoxide dismutase; detoxifies superoxide and is involved in repressing respiration in the presence of glucose, via stabilization of Yck1p and Yck2p kinases; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 

    Range
    622550..623014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181762.1NP_012638.1  superoxide dismutase SOD1 [Saccharomyces cerevisiae S288c]

    See proteins identical to NP_012638.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P00445
    Conserved Domains (1) summary
    cd00305
    Location:2147
    Blast Score: 465
    Cu-Zn_Superoxide_Dismutase; Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the ...