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Tcp1 t-complex protein 1 [ Mus musculus (house mouse) ]

Gene ID: 21454, updated on 16-Dec-2014
Official Symbol
Tcp1provided by MGI
Official Full Name
t-complex protein 1provided by MGI
Primary source
MGI:MGI:98535
Locus tag
RP23-351C7.3
See related
Ensembl:ENSMUSG00000068039; Vega:OTTMUSG00000028087
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CCT; p63; Cct1; Ccta; TRic; Tp63; Tcp-1; c-cpn; AI528772
See Tcp1 in Epigenomics, MapViewer
Location:
17 A3-B; 17 8.72 cM
Exon count:
12
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 17 NC_000083.6 (12916334..12925067)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene MAS-related GPR, member H Neighboring gene poly(A)-specific ribonuclease (PARN)-like domain containing 1 Neighboring gene mitochondrial ribosomal protein L18 Neighboring gene small nucleolar RNA, H/ACA box 20 Neighboring gene acetyl-Coenzyme A acetyltransferase 3 Neighboring gene t-complex protein 1, pseudogene 2 Neighboring gene acetyl-Coenzyme A acetyltransferase 2 Neighboring gene predicted gene 15946

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
binding of sperm to zona pellucida IDA
Inferred from Direct Assay
more info
PubMed 
cellular protein metabolic process IEA
Inferred from Electronic Annotation
more info
 
protein folding IEA
Inferred from Electronic Annotation
more info
 
regulation of macrophage apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
toxin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
translocation of peptides or proteins into host cell cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
acrosomal vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cell body IDA
Inferred from Direct Assay
more info
PubMed 
centrosome ISO
Inferred from Sequence Orthology
more info
 
chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
heterochromatin ISO
Inferred from Sequence Orthology
more info
 
microtubule ISO
Inferred from Sequence Orthology
more info
 
microtubule organizing center IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
nuclear heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
pericentriolar material IDA
Inferred from Direct Assay
more info
PubMed 
zona pellucida receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
T-complex protein 1 subunit alpha
Names
T-complex protein 1 subunit alpha
TCP-1-A
TCP-1-B
CCT-alpha
TCP-1-alpha
t-complex polypeptide 1
tailless complex polypeptide 1A
tailless complex polypeptide 1B
T-complex protein 1 subunit alpha A
T-complex protein 1 subunit alpha B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290712.1NP_001277641.1  T-complex protein 1 subunit alpha isoform 2

    See proteins identical to NP_001277641.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and initiates translation at an alternate start codon compared to variant 1. The encoded protein (isoform 2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK149611, AK153430, CN725473
    Consensus CDS
    CCDS70760.1
    UniProtKB/Swiss-Prot
    P11983
    Conserved Domains (1) summary
    cd03335
    Location:2486
    TCP1_alpha; TCP-1 (CTT or eukaryotic type II) chaperonin family, alpha subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...
  2. NM_013686.4NP_038714.2  T-complex protein 1 subunit alpha isoform 1

    See proteins identical to NP_038714.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AK149611, AK166966, CN725473
    Consensus CDS
    CCDS28397.1
    UniProtKB/Swiss-Prot
    P11983
    Related
    ENSMUSP00000116108, OTTMUSP00000035355, ENSMUST00000151287, OTTMUST00000069571
    Conserved Domains (1) summary
    cd03335
    Location:9535
    TCP1_alpha; TCP-1 (CTT or eukaryotic type II) chaperonin family, alpha subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000083.6 

    Range
    12916334..12925067
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523312.1XP_006523375.1  

    Related
    ENSMUSP00000086418, OTTMUSP00000035356, ENSMUST00000089024, OTTMUST00000069573
    Conserved Domains (1) summary
    cd03335
    Location:2486
    TCP1_alpha; TCP-1 (CTT or eukaryotic type II) chaperonin family, alpha subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...

Alternate Mm_Celera

Genomic

  1. AC_000039.1 

    Range
    12948013..12956616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)