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Pglyrp2 peptidoglycan recognition protein 2 [ Mus musculus (house mouse) ]

Gene ID: 57757, updated on 26-Aug-2014
Official Symbol
Pglyrp2provided by MGI
Official Full Name
peptidoglycan recognition protein 2provided by MGI
Primary source
MGI:1928099
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
tagL; PGRP-L; Pglyrpl; C730002N09Rik
See Pglyrp2 in Epigenomics, MapViewer
Location:
17 B1; 17
Exon count:
6
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 17 NC_000083.6 (32412459..32424180, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene widely-interspaced zinc finger motifs Neighboring gene RIKEN cDNA A530088E08 gene Neighboring gene RAS protein activator like 3 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 39 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 17

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
N-acetylmuramoyl-L-alanine amidase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
peptidoglycan binding ISO
Inferred from Sequence Orthology
more info
 
peptidoglycan receptor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
detection of bacterium ISO
Inferred from Sequence Orthology
more info
 
growth of symbiont in host IMP
Inferred from Mutant Phenotype
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of natural killer cell differentiation involved in immune response IMP
Inferred from Mutant Phenotype
more info
 
pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
peptidoglycan catabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
N-acetylmuramoyl-L-alanine amidase
Names
N-acetylmuramoyl-L-alanine amidase
peptidoglycan recognition protein long
NP_001258405.1
NP_001258406.1
NP_001258407.1
NP_001258408.1
NP_067294.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271476.1NP_001258405.1  N-acetylmuramoyl-L-alanine amidase isoform a precursor

    See proteins identical to NP_001258405.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a, also known as TagL-alpha).
    Source sequence(s)
    AK039953, AY282722, CT485616
    Consensus CDS
    CCDS37557.1
    UniProtKB/Swiss-Prot
    Q8VCS0
    Conserved Domains (1) summary
    cd06583
    Location:386514
    Blast Score: 335
    PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...
  2. NM_001271477.1NP_001258406.1  N-acetylmuramoyl-L-alanine amidase isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK050019, CT485616
    Conserved Domains (1) summary
    cl02712
    Location:360421
    Blast Score: 194
    PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...
  3. NM_001271478.1NP_001258407.1  N-acetylmuramoyl-L-alanine amidase isoform c precursor

    See proteins identical to NP_001258407.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (c, also known as TagL-epsilon) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK039953, AY282722, CT485616
    UniProtKB/Swiss-Prot
    Q8VCS0
    Conserved Domains (1) summary
    cl02712
    Location:360427
    Blast Score: 242
    PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...
  4. NM_001271479.1NP_001258408.1  N-acetylmuramoyl-L-alanine amidase isoform d precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site and lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (d, also known as TagL-delta) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AY282722, CT485616
    UniProtKB/Swiss-Prot
    Q8VCS0
  5. NM_021319.5NP_067294.2  N-acetylmuramoyl-L-alanine amidase isoform a precursor

    See proteins identical to NP_067294.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 encode the same isoform (a, also known as TagL-alpha).
    Source sequence(s)
    AK050019, AY282722, CT485616
    Consensus CDS
    CCDS37557.1
    UniProtKB/Swiss-Prot
    Q8VCS0
    Conserved Domains (1) summary
    cd06583
    Location:386514
    Blast Score: 335
    PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...

RNA

  1. NR_073184.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY282722, CT485616

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000083.6 

    Range
    32412459..32424180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524714.1XP_006524777.1  

    See proteins identical to XP_006524777.1

    UniProtKB/Swiss-Prot
    Q8VCS0
    Conserved Domains (1) summary
    cl02712
    Location:360427
    Blast Score: 242
    PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...
  2. XM_006524713.1XP_006524776.1  

    Conserved Domains (1) summary
    cl02712
    Location:360421
    Blast Score: 194
    PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...
  3. XM_006524712.1XP_006524775.1  

    See proteins identical to XP_006524775.1

    Conserved Domains (1) summary
    cd06583
    Location:386514
    Blast Score: 337
    PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...
  4. XM_006524711.1XP_006524774.1  

    See proteins identical to XP_006524774.1

    Conserved Domains (1) summary
    cd06583
    Location:386514
    Blast Score: 337
    PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...
  5. XM_006524710.1XP_006524773.1  

    See proteins identical to XP_006524773.1

    Conserved Domains (1) summary
    cd06583
    Location:386514
    Blast Score: 337
    PGRP; Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20 ...

Alternate Mm_Celera

Genomic

  1. AC_000039.1 

    Range
    33324981..33336694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)