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C5ar2 complement component 5a receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 319430, updated on 25-Mar-2015
Official Symbol
C5ar2provided by MGI
Official Full Name
complement component 5a receptor 2provided by MGI
Primary source
MGI:MGI:2442013
See related
Ensembl:ENSMUSG00000074361
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C5L2; Gpr77; E030029A11Rik
Orthologs
See C5ar2 in MapViewer
Location:
7; 7 A2
Exon count:
12
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (16234585..16244154, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (16819934..16829503, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene Meis homeobox 3 Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 34 Neighboring gene complement component 5a receptor 1 Neighboring gene InaF motif containing 1 Neighboring gene coiled-coil domain containing 9

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
C5a anaphylatoxin receptor activity IEA
Inferred from Electronic Annotation
more info
 
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-6 secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of interleukin-8 secretion ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical part of cell ISO
Inferred from Sequence Orthology
more info
 
basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
C5a anaphylatoxin chemotactic receptor 2
Names
C5a anaphylatoxin chemotactic receptor 2
C5a anaphylatoxin chemotactic receptor C5L2
G protein-coupled receptor 77
G-protein coupled receptor 77

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146005.1NP_001139477.1  C5a anaphylatoxin chemotactic receptor 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a distinct N-terminus but is the same length as isoform 1.
    Source sequence(s)
    AK053187, AK160050, BC145834, BY540170
    Consensus CDS
    CCDS52036.1
    UniProtKB/TrEMBL
    E9QQ21
    UniProtKB/Swiss-Prot
    Q8BW93
    Related
    ENSMUSP00000096389, ENSMUST00000098792
    Conserved Domains (1) summary
    pfam00001
    Location:92309
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_176912.4NP_795886.2  C5a anaphylatoxin chemotactic receptor 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
    Source sequence(s)
    AK053187, AK160050, BC145834, BY540170
    Consensus CDS
    CCDS52037.1
    UniProtKB/TrEMBL
    E9PVQ2
    UniProtKB/Swiss-Prot
    Q8BW93
    Related
    ENSMUSP00000133056, ENSMUST00000171425
    Conserved Domains (1) summary
    pfam00001
    Location:92309
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    16234585..16244154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250594.1XP_011248896.1  

    Conserved Domains (1) summary
    pfam00001
    Location:92309
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. XM_006540053.2XP_006540116.1  

    See identical proteins and their annotated locations for XP_006540116.1

    UniProtKB/Swiss-Prot
    Q8BW93
    Conserved Domains (1) summary
    pfam00001
    Location:78295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. XM_011250595.1XP_011248897.1  

    Conserved Domains (1) summary
    pfam00001
    Location:92309
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. XM_006540052.2XP_006540115.1  

    See identical proteins and their annotated locations for XP_006540115.1

    UniProtKB/Swiss-Prot
    Q8BW93
    Conserved Domains (1) summary
    pfam00001
    Location:78295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  5. XM_006540054.2XP_006540117.1  

    See identical proteins and their annotated locations for XP_006540117.1

    UniProtKB/Swiss-Prot
    Q8BW93
    Conserved Domains (1) summary
    pfam00001
    Location:78295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  6. XM_006540055.2XP_006540118.1  

    See identical proteins and their annotated locations for XP_006540118.1

    UniProtKB/Swiss-Prot
    Q8BW93
    Conserved Domains (1) summary
    pfam00001
    Location:78295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  7. XM_006540049.2XP_006540112.2  

    See identical proteins and their annotated locations for XP_006540112.2

    UniProtKB/Swiss-Prot
    Q8BW93
    Conserved Domains (1) summary
    pfam00001
    Location:78295
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  8. XM_006540050.2XP_006540113.1  

    Conserved Domains (1) summary
    pfam00001
    Location:103320
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  9. XM_006540057.2XP_006540120.2  

    UniProtKB/Swiss-Prot
    Q8BW93
    Conserved Domains (1) summary
    pfam00001
    Location:115332
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  10. XM_006540051.2XP_006540114.1  

    Conserved Domains (1) summary
    pfam00001
    Location:94311
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  11. XM_006540056.2XP_006540119.1  

    See identical proteins and their annotated locations for XP_006540119.1

    UniProtKB/Swiss-Prot
    Q8BW93
    Conserved Domains (1) summary
    pfam00001
    Location:78295
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RNA

  1. XR_881730.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    13426639..13438094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)