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    Ube2i ubiquitin-conjugating enzyme E2I [ Mus musculus (house mouse) ]

    Gene ID: 22196, updated on 8-Aug-2016
    Official Symbol
    Ube2iprovided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2Iprovided by MGI
    Primary source
    MGI:MGI:107365
    See related
    Ensembl:ENSMUSG00000015120 Vega:OTTMUSG00000037656
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UBC9; Ubce9; Ubce2i; 5830467E05Rik; F830028O17Rik
    Orthologs
    Location:
    17; 17 A3.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (25260510..25274310, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (25397456..25411255, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene N-acetylglucosamine-1-phosphotransferase, gamma subunit Neighboring gene TSR3 20S rRNA accumulation Neighboring gene BAI1-associated protein 3 Neighboring gene microRNA 3547 Neighboring gene predicted gene, 17801 Neighboring gene protease, serine 34 Neighboring gene protease, serine 28

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    HLH domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RING-like zinc finger domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    SUMO conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    SUMO transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    bHLH transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    coenzyme F420-0 gamma-glutamyl ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    coenzyme F420-2 alpha-glutamyl ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A) RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-glutamic acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein-glycine ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein-glycine ligase activity, elongating IEA
    Inferred from Electronic Annotation
    more info
     
    protein-glycine ligase activity, initiating IEA
    Inferred from Electronic Annotation
    more info
     
    ribosomal S6-glutamic acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    tubulin-glutamic acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    tubulin-glycine ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein modification process TAS
    Traceable Author Statement
    more info
    PubMed 
    chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of intracellular steroid hormone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    PML body ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
     
    transferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    SUMO-conjugating enzyme UBC9
    Names
    SUMO-protein ligase
    ubiquitin carrier protein 9
    ubiquitin carrier protein I
    ubiquitin-protein ligase I
    NP_001171080.1
    NP_001171081.1
    NP_035795.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177609.1NP_001171080.1  SUMO-conjugating enzyme UBC9

      See identical proteins and their annotated locations for NP_001171080.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK150575, AK166657, AK166930
      Consensus CDS
      CCDS28513.1
      UniProtKB/Swiss-Prot
      P63280
      Related
      ENSMUSP00000134169, OTTMUSP00000054465, ENSMUST00000172618, OTTMUST00000097205
      Conserved Domains (2) summary
      COG5078
      Location:1156
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00195
      Location:7152
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    2. NM_001177610.1NP_001171081.1  SUMO-conjugating enzyme UBC9

      See identical proteins and their annotated locations for NP_001171081.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 2. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC122454, AK166930
      Consensus CDS
      CCDS28513.1
      UniProtKB/Swiss-Prot
      P63280
      Related
      ENSMUSP00000134350, OTTMUSP00000054544, ENSMUST00000174031, OTTMUST00000097280
      Conserved Domains (2) summary
      COG5078
      Location:1156
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00195
      Location:7152
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    3. NM_011665.4NP_035795.1  SUMO-conjugating enzyme UBC9

      See identical proteins and their annotated locations for NP_035795.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK005058, BY074880
      Consensus CDS
      CCDS28513.1
      UniProtKB/Swiss-Prot
      P63280
      Related
      ENSMUSP00000134491, OTTMUSP00000054464, ENSMUST00000173713, OTTMUST00000097204
      Conserved Domains (2) summary
      COG5078
      Location:1156
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00195
      Location:7152
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      25260510..25274310 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524049.3XP_006524112.1  

      See identical proteins and their annotated locations for XP_006524112.1

      UniProtKB/Swiss-Prot
      P63280
      Related
      ENSMUSP00000055714, OTTMUSP00000054462, ENSMUST00000049911, OTTMUST00000097202
      Conserved Domains (2) summary
      COG5078
      Location:1156
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00195
      Location:7152
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    2. XM_006524048.3XP_006524111.1  

      See identical proteins and their annotated locations for XP_006524111.1

      UniProtKB/Swiss-Prot
      P63280
      Conserved Domains (2) summary
      COG5078
      Location:1156
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00195
      Location:7152
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...