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    POR P450 (cytochrome) oxidoreductase [ Homo sapiens (human) ]

    Gene ID: 5447, updated on 23-Aug-2015
    Official Symbol
    PORprovided by HGNC
    Official Full Name
    P450 (cytochrome) oxidoreductaseprovided by HGNC
    Primary source
    HGNC:HGNC:9208
    See related
    Ensembl:ENSG00000127948; HPRD:00485; MIM:124015; Vega:OTTHUMG00000130413
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPR; CYPOR; P450R
    Summary
    This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    7q11.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (75915102..75986855)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (75544420..75616173)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene THO complex 4 pseudogene Neighboring gene rhomboid domain containing 2 Neighboring gene microRNA 4651 Neighboring gene ribosomal protein L7-like 1 pseudogene 3 Neighboring gene small nucleolar RNA, H/ACA box 14A Neighboring gene transmembrane protein 120A Neighboring gene serine/threonine/tyrosine interacting-like 1 Neighboring gene malate dehydrogenase 2, NAD (mitochondrial)

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • bile acid biosynthesis, neutral pathway, organism-specific biosystem (from BIOCYC)
      bile acid biosynthesis, neutral pathway, organism-specific biosystemGeneral Background The biosynthesis of bile acids is a major route of : CHOLESTEROL catabolism. It converts the hydrophobic, insoluble : CHOLESTEROL molecule into soluble bile acids. Accumulation ...
    • bile acid biosynthesis, neutral pathway, conserved biosystem (from BIOCYC)
      bile acid biosynthesis, neutral pathway, conserved biosystemGeneral Background The biosynthesis of bile acids is a major route of |FRAME: CHOLESTEROL| catabolism. It converts the hydrophobic, insoluble |FRAME: CHOLESTEROL| molecule into soluble bile acids. ...
    • cytochrome P450, organism-specific biosystem (from WikiPathways)
      cytochrome P450, organism-specific biosystemOxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.
    • melatonin degradation I, organism-specific biosystem (from BIOCYC)
      melatonin degradation I, organism-specific biosystemGeneral Background The indoleamine : N-ACETYL-5-METHOXY-TRYPTAMINE is a vertebrate hormone secreted by the pineal gland. It is involved in regulation of circadian and seasonal rhythms. : N-ACETYL-...
    • melatonin degradation I, conserved biosystem (from BIOCYC)
      melatonin degradation I, conserved biosystemGeneral Background The indoleamine |FRAME: N-ACETYL-5-METHOXY-TRYPTAMINE| is a vertebrate hormone secreted by the pineal gland. It is involved in regulation of circadian and seasonal rhythms. |FRA...
    • superpathway of melatonin degradation, conserved biosystem (from BIOCYC)
      superpathway of melatonin degradation, conserved biosystemThe indoleamine |FRAME: N-ACETYL-5-METHOXY-TRYPTAMINE| is a vertebrate hormone secreted by the pineal gland. It is involved in regulation of circadian and seasonal rhythms. |FRAME: N-ACETYL-5-METHO...
    • superpathway of melatonin degradation, organism-specific biosystem (from BIOCYC)
      superpathway of melatonin degradation, organism-specific biosystem
      superpathway of melatonin degradation
    • superpathway of tryptophan utilization, organism-specific biosystem (from BIOCYC)
      superpathway of tryptophan utilization, organism-specific biosystem
      superpathway of tryptophan utilization
    • vitamin D3 biosynthesis, organism-specific biosystem (from BIOCYC)
      vitamin D3 biosynthesis, organism-specific biosystemGeneral Background Vitamin D occurs in two forms, : VITAMIN_D3 (cholecalciferol) produced in animal skin after exposure to : UV-Light and : Heat, and : VITAMIN_D2 (ergocalciferol) produced in plants...
    • vitamin D3 biosynthesis, conserved biosystem (from BIOCYC)
      vitamin D3 biosynthesis, conserved biosystemGeneral Background Vitamin D refers to a group of fat-soluble secosteroids responsible for enhancing intestinal absorption of calcium, iron, magnesium, phosphate and zinc. In humans, the most impor...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ26468, DKFZp686G04235

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    FMN binding IEA
    Inferred from Electronic Annotation
    more info
     
    NADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    NADPH-hemoprotein reductase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NADPH-hemoprotein reductase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    cytochrome-b5 reductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
     
    electron carrier activity IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme binding IEA
    Inferred from Electronic Annotation
    more info
     
    flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    iron-cytochrome-c reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nitric oxide dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    carnitine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular organofluorine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to follicle-stimulating hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to peptide hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    demethylation IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    flavonoid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    internal peptidyl-lysine acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of lipase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nitrate catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    nitric oxide catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidation-reduction process TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of cholesterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of chondrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of steroid hormone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of growth plate cartilage chondrocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    NADPH--cytochrome P450 reductase
    Names
    NADPH-dependent cytochrome P450 reductase
    NP_000932.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008930.1 RefSeqGene

      Range
      5001..76754
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000941.2NP_000932.3  NADPH--cytochrome P450 reductase

      See identical proteins and their annotated locations for NP_000932.3

      Status: REVIEWED

      Source sequence(s)
      AF258341, AK129978, BC034277, BG104767, BP244929, DA701694
      Consensus CDS
      CCDS5579.1
      UniProtKB/Swiss-Prot
      P16435
      Related
      ENSP00000419970, OTTHUMP00000160964, ENST00000461988, OTTHUMT00000252796
      Conserved Domains (3) summary
      cd06204
      Location:280679
      CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
      COG0369
      Location:55679
      CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
      pfam00258
      Location:85222
      Flavodoxin_1; Flavodoxin

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

      Range
      75915102..75986855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      75474511..75546243
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)