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    Cdc42 cell division cycle 42 [ Mus musculus (house mouse) ]

    Gene ID: 12540, updated on 23-Aug-2016
    Official Symbol
    Cdc42provided by MGI
    Official Full Name
    cell division cycle 42provided by MGI
    Primary source
    MGI:MGI:106211
    See related
    Ensembl:ENSMUSG00000006699 Vega:OTTMUSG00000009829
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI747189; AU018915
    Orthologs
    Location:
    4 D3; 4 69.83 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (137319696..137357759, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (136875611..136913652, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31820 Neighboring gene chromobox homolog 5 pseudogene Neighboring gene wingless-type MMTV integration site family, member 4 Neighboring gene spidroin-2-like Neighboring gene ribosomal protein L31, pseudogene 10 Neighboring gene chymotrypsin-like elastase family, member 3A

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    GTP-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    GTPase activity ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Rho GDP-dissociation inhibitor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT Rho GDP-dissociation inhibitor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitogen-activated protein kinase kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    Rho protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    actin filament branching ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament bundle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    actin filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    adherens junction organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac conduction system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendritic cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endosomal transport TAS
    Traceable Author Statement
    more info
    PubMed 
    epidermis morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial-mesenchymal cell signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of Golgi localization ISO
    Inferred from Sequence Orthology
    more info
     
    establishment or maintenance of apical/basal cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment or maintenance of cell polarity TAS
    Traceable Author Statement
    more info
    PubMed 
    filopodium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hair follicle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hair follicle placode formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart contraction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    keratinization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    keratinocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    neuron fate determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleus localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    organelle transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell proliferation involved in lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of hair follicle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of synapse structural plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein stability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    single organismal cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    single organismal cell-cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leading edge membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    storage vacuole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    cell division control protein 42 homolog
    Names
    G25K GTP-binding protein
    cell division cycle 42 homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243769.1NP_001230698.1  cell division control protein 42 homolog isoform 2

      See identical proteins and their annotated locations for NP_001230698.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2, which is the same length but has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL645468, BF467211, CD353254, CD551112, L78075
      Consensus CDS
      CCDS57305.1
      UniProtKB/Swiss-Prot
      P60766
      Related
      ENSMUSP00000030417, OTTMUSP00000010389, ENSMUST00000030417, OTTMUST00000022762
      Conserved Domains (2) summary
      smart00174
      Location:6179
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
      cd01874
      Location:3177
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
    2. NM_009861.3NP_033991.1  cell division control protein 42 homolog isoform 1 precursor

      See identical proteins and their annotated locations for NP_033991.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
      Source sequence(s)
      AK168758, AL645468, BE685696, CD551112
      Consensus CDS
      CCDS18816.1
      UniProtKB/Swiss-Prot
      P60766
      Related
      ENSMUSP00000054634, OTTMUSP00000010388, ENSMUST00000051477, OTTMUST00000022761
      Conserved Domains (2) summary
      cd01874
      Location:3177
      Cdc42; cell division cycle 42 (Cdc42) is a small GTPase of the Rho family
      pfam00071
      Location:5178
      Ras; Ras family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      137319696..137357759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)