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    NPPB natriuretic peptide B [ Homo sapiens (human) ]

    Gene ID: 4879, updated on 22-Sep-2016
    Official Symbol
    NPPBprovided by HGNC
    Official Full Name
    natriuretic peptide Bprovided by HGNC
    Primary source
    HGNC:HGNC:7940
    See related
    Ensembl:ENSG00000120937 HPRD:08974; MIM:600295; Vega:OTTHUMG00000002389
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BNP
    Summary
    This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]
    Orthologs
    Location:
    1p36.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (11857464..11858935, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11917521..11918992, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene methylenetetrahydrofolate reductase Neighboring gene chloride voltage-gated channel 6 Neighboring gene NPPA antisense RNA 1 Neighboring gene natriuretic peptide A Neighboring gene SET binding factor 1 pseudogene Neighboring gene RNA, U5E small nuclear 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies eight loci associated with blood pressure.
    NHGRI GWA Catalog
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    NHGRI GWA Catalog
    • MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
      MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red dashed lin...
    • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
      cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
      cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    diuretic hormone activity TAS
    Traceable Author Statement
    more info
    PubMed 
    hormone activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    body fluid secretion TAS
    Traceable Author Statement
    more info
    PubMed 
    cGMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of angiogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cell growth NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of renal sodium excretion TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of urine volume TAS
    Traceable Author Statement
    more info
    PubMed 
    receptor guanylyl cyclase signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of blood pressure NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of vascular permeability TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of vasodilation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular space NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    natriuretic peptides B
    Names
    brain type natriuretic peptide
    gamma-brain natriuretic peptide
    natriuretic peptide precursor B
    natriuretic protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002521.2NP_002512.1  natriuretic peptides B preproprotein

      See identical proteins and their annotated locations for NP_002512.1

      Status: REVIEWED

      Source sequence(s)
      AJ708502, BC025785, M25296
      Consensus CDS
      CCDS140.1
      UniProtKB/Swiss-Prot
      P16860
      Related
      ENSP00000365651, OTTHUMP00000002506, ENST00000376468, OTTHUMT00000006854
      Conserved Domains (1) summary
      pfam00212
      Location:98128
      ANP; Atrial natriuretic peptide

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      11857464..11858935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      11905417..11906888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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