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SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 [ Homo sapiens (human) ]

Gene ID: 9194, updated on 19-Jul-2014
Official Symbol
SLC16A7provided by HGNC
Official Full Name
solute carrier family 16 (monocarboxylate transporter), member 7provided by HGNC
Primary source
HGNC:10928
See related
Ensembl:ENSG00000118596; HPRD:06791; MIM:603654; Vega:OTTHUMG00000169923
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCT2
Summary
This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
See SLC16A7 in Epigenomics, MapViewer
Location:
12q13
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 12 NC_000012.12 (59596040..59789855)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (59989821..60183636)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene methyltransferase like 15 pseudogene 2 Neighboring gene ribosomal protein S6 pseudogene 22 Neighboring gene polyadenylate-binding protein 4-like Neighboring gene piggyBac transposable element derived 3 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
lactate transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
pyruvate transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
monocarboxylate transporter 2
Names
monocarboxylate transporter 2
solute carrier family 16, member 7 (monocarboxylic acid transporter 2)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270622.1NP_001257551.1  monocarboxylate transporter 2

    See proteins identical to NP_001257551.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC079905, AF058056, BC007463, BC030693, DR000391
    Consensus CDS
    CCDS8961.1
    UniProtKB/Swiss-Prot
    O60669
    Conserved Domains (2) summary
    cd06174
    Location:20423
    Blast Score: 295
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:15449
    Blast Score: 1988
    2A0113; monocarboxylate transporter 1
  2. NM_001270623.1NP_001257552.1  monocarboxylate transporter 2

    See proteins identical to NP_001257552.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC079905, AF049608, AF058056, BC007463, BC030693, DR000391
    Consensus CDS
    CCDS8961.1
    UniProtKB/Swiss-Prot
    O60669
    Conserved Domains (2) summary
    cd06174
    Location:20423
    Blast Score: 295
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:15449
    Blast Score: 1988
    2A0113; monocarboxylate transporter 1
  3. NM_004731.4NP_004722.2  monocarboxylate transporter 2

    See proteins identical to NP_004722.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC079905, AF058056, BC030693, DC394954
    Consensus CDS
    CCDS8961.1
    UniProtKB/Swiss-Prot
    O60669
    Conserved Domains (2) summary
    cd06174
    Location:20423
    Blast Score: 295
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:15449
    Blast Score: 1988
    2A0113; monocarboxylate transporter 1

RNA

  1. NR_073055.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' end and uses two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC079905, AF058056, AK301725, BC030693, DC394954
  2. NR_073056.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' end and uses two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC079905, AF058056, AK310281, BC030693, DC394954

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12 

    Range
    59596040..59789855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719693.1XP_006719756.1  

    See proteins identical to XP_006719756.1

    UniProtKB/Swiss-Prot
    O60669
    Conserved Domains (2) summary
    cd06174
    Location:20423
    Blast Score: 295
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:15449
    Blast Score: 1988
    2A0113; monocarboxylate transporter 1
  2. XM_005269231.2XP_005269288.1  

    See proteins identical to XP_005269288.1

    UniProtKB/Swiss-Prot
    O60669
    Related
    ENSP00000261187, OTTHUMP00000242486
    Conserved Domains (2) summary
    cd06174
    Location:20423
    Blast Score: 295
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00892
    Location:15449
    Blast Score: 1988
    2A0113; monocarboxylate transporter 1

Alternate HuRef

Genomic

  1. AC_000144.1 

    Range
    57038268..57232240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 

    Range
    59958039..60151803
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)