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    Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 [ Mus musculus (house mouse) ]

    Gene ID: 27103, updated on 7-Feb-2016
    Official Symbol
    Eif2ak4provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 2 alpha kinase 4provided by MGI
    Primary source
    MGI:MGI:1353427
    See related
    Ensembl:ENSMUSG00000005102; Vega:OTTMUSG00000015229
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GCN2; MGCN2; 2610011M03
    Orthologs
    See Eif2ak4 in Epigenomics, MapViewer
    Location:
    2; 2 E5
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (118388578..118475234)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (118214353..118300970)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene fibrous sheath-interacting protein 1 Neighboring gene RIKEN cDNA 1700054M17 gene Neighboring gene G protein-coupled receptor 176 Neighboring gene aldo-keto reductase family 1, member B3 pseudogene Neighboring gene signal recognition particle 14

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Chemically induced (ENU) (1) 
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Hepatitis C, organism-specific biosystem (from KEGG)
      Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Hepatitis C, conserved biosystem (from KEGG)
      Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    eukaryotic initiation factor eIF2 binding IC
    Inferred by Curator
    more info
    PubMed 
    eukaryotic translation initiation factor 2alpha kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    eukaryotic translation initiation factor 2alpha kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    eukaryotic translation initiation factor 2alpha kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    eukaryotic translation initiation factor 2alpha kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    T cell activation involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to UV IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to amino acid starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to amino acid starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to cold ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to leucine starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    eiF2alpha phosphorylation in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    induction by virus of host autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation by host of viral genome replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of CREB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of translation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of translational initiation in response to stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of adaptive immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of defense response to virus by host IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of translational initiation in response to starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of translational initiation in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of eIF2 alpha phosphorylation by amino acid starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of eIF2 alpha phosphorylation by amino acid starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of eIF2 alpha phosphorylation by amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of translational initiation by eIF2 alpha phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of translational initiation by eIF2 alpha phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of translational initiation by eIF2 alpha phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of translational initiation by eIF2 alpha phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of translational initiation in response to stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to endoplasmic reticulum stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    viral translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosolic ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    polysome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    eukaryotic translation initiation factor 2-alpha kinase 4
    Names
    GCN2 eIF2alpha kinase
    GCN2-like protein
    NP_001171277.1
    NP_038747.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177806.1NP_001171277.1  eukaryotic translation initiation factor 2-alpha kinase 4 isoform 2

      See identical proteins and their annotated locations for NP_001171277.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter when it compared to isoform 1.
      Source sequence(s)
      AI324072, AI643894, BC072637
      Consensus CDS
      CCDS50669.1
      UniProtKB/Swiss-Prot
      Q9QZ05
      Related
      ENSMUSP00000099586, ENSMUST00000102527
      Conserved Domains (6) summary
      smart00220
      Location:477888
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG0124
      Location:9371373
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd14012
      Location:187425
      PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
      cd14046
      Location:470886
      STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
      cl00266
      Location:12821528
      HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...
      cl00268
      Location:9481272
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...
    2. NM_013719.3NP_038747.2  eukaryotic translation initiation factor 2-alpha kinase 4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. It encodes the longer protein (isoform 1).
      Source sequence(s)
      AI324072, AK013758, AL929163, BF453236, BF462783, BG086385, BM250244, CB723221, CF748039, CN527645, CO430666, W75391
      Consensus CDS
      CCDS16576.1
      UniProtKB/TrEMBL
      A2AUM0
      UniProtKB/Swiss-Prot
      Q9QZ05
      Related
      ENSMUSP00000005233, OTTMUSP00000016209, ENSMUST00000005233, OTTMUST00000036076
      Conserved Domains (7) summary
      smart00220
      Location:5891000
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00591
      Location:26137
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      COG0124
      Location:10491485
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd14012
      Location:299537
      PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
      cd14046
      Location:582998
      STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
      cl00266
      Location:13941640
      HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...
      cl00268
      Location:10601384
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

      Range
      118388578..118475234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499625.2XP_006499688.1  

      See identical proteins and their annotated locations for XP_006499688.1

      UniProtKB/Swiss-Prot
      Q9QZ05
      Conserved Domains (6) summary
      smart00220
      Location:477888
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG0124
      Location:9371373
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd14012
      Location:187425
      PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
      cd14046
      Location:470886
      STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
      cl00266
      Location:12821528
      HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...
      cl00268
      Location:9481272
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...
    2. XM_006499626.2XP_006499689.1  

      Conserved Domains (6) summary
      smart00220
      Location:466877
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG0124
      Location:9261362
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd14012
      Location:176414
      PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
      cd14046
      Location:459875
      STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
      cl00266
      Location:12711517
      HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...
      cl00268
      Location:9371261
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...
    3. XM_006499627.2XP_006499690.1  

      Conserved Domains (6) summary
      smart00220
      Location:439850
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG0124
      Location:8991335
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd14012
      Location:149387
      PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
      cd14046
      Location:432848
      STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
      cl00266
      Location:12441490
      HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...
      cl00268
      Location:9101234
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...
    4. XM_006499628.1XP_006499691.1  

      Related
      ENSMUSP00000106494, OTTMUSP00000016212, ENSMUST00000110870, OTTMUST00000036079
      Conserved Domains (6) summary
      smart00220
      Location:399810
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG0124
      Location:8591295
      HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
      cd14012
      Location:109347
      PK_eIF2AK_GCN2_rpt1; Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
      cd14046
      Location:392808
      STKc_EIF2AK4_GCN2_rpt2; Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2
      cl00266
      Location:12041450
      HGTP_anticodon; HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for ...
      cl00268
      Location:8701194
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...

    Alternate Mm_Celera

    Genomic

    1. AC_000024.1 Alternate Mm_Celera

      Range
      119539566..119626375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)