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    BCL2L11 BCL2-like 11 (apoptosis facilitator) [ Homo sapiens (human) ]

    Gene ID: 10018, updated on 26-Jul-2015
    Official Symbol
    BCL2L11provided by HGNC
    Official Full Name
    BCL2-like 11 (apoptosis facilitator)provided by HGNC
    Primary source
    HGNC:HGNC:994
    See related
    Ensembl:ENSG00000153094; HPRD:04828; MIM:603827; Vega:OTTHUMG00000131256
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BAM; BIM; BOD
    Summary
    The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]
    Orthologs
    See BCL2L11 in Epigenomics, MapViewer
    Location:
    2q13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (111120618..111168445)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (111878491..111926022)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene acyl-CoA oxidase-like Neighboring gene uncharacterized LOC105373556 Neighboring gene uncharacterized LOC400997 Neighboring gene uncharacterized LOC101927260 Neighboring gene uncharacterized LOC101927283

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
    NHGRI GWA Catalog
    A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
    NHGRI GWA Catalog
    Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
    NHGRI GWA Catalog
    Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.
    NHGRI GWA Catalog
    Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates BIM expression in Tat-infected Jurkat T cells PubMed
    tat HIV-1 Tat acetylation at position K28 stimulates its activity to induce the translocation of Bim, a pro-apoptotic protein of the Bcl-2 family, from microtubules to mitochondria PubMed
    tat HIV-1 Tat (amino acids 36-39) binds tubulin alpha/beta dimers and polymerized microtubules leading to the alteration of microtubule dynamics and activation of a mitochondria-dependent apoptotic pathway that is facilitated by the Bcl-2 relative Bim PubMed

    Go to the HIV-1, Human Interaction Database

    • Activation of BH3-only proteins, organism-specific biosystem (from REACTOME)
      Activation of BH3-only proteins, organism-specific biosystemThe BH3-only members act as sentinels that selectively trigger apoptosis in response to developmental cues or stress-signals like DNA damages. Widely expressed mammalian BH3-only proteins are thought...
    • Activation of BIM and translocation to mitochondria, organism-specific biosystem (from REACTOME)
      Activation of BIM and translocation to mitochondria, organism-specific biosystemBIM acts as a sentinel to check the integrity of the cytoskeleton. It exists as two variant proteins: BIM-EL and BIM-L. In healthy cells, these two isoforms are sequestered to the dynein motor comple...
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis Modulation and Signaling, organism-specific biosystem (from WikiPathways)
      Apoptosis Modulation and Signaling, organism-specific biosystemApoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrin...
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • BDNF signaling pathway, organism-specific biosystem (from WikiPathways)
      BDNF signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
    • BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem (from REACTOME)
      BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem
      BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
    • Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
      Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemp75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNG...
    • DNA damage response (only ATM dependent), organism-specific biosystem (from WikiPathways)
      DNA damage response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway. In...
    • ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
      ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
    • FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
      FoxO family signaling, organism-specific biosystem
      FoxO family signaling
    • FoxO signaling pathway, organism-specific biosystem (from KEGG)
      FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
    • IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-7 Signaling Pathway, organism-specific biosystemInterleukin-7 belongs to a family of cytokines, which includes IL-2, IL-4, IL-9, IL-15 and IL-21. It signals through a receptor complex consisting of IL-7 receptor alpha chain (IL7RA) and a common ga...
    • Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
      Intrinsic Pathway for Apoptosis, organism-specific biosystemThe intrinsic (Bcl-2 inhibitable or mitochondrial) pathway of apoptosis functions in response to various types of intracellular stress including growth factor withdrawal, DNA damage, unfolding stress...
    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • NRAGE signals death through JNK, organism-specific biosystem (from REACTOME)
      NRAGE signals death through JNK, organism-specific biosystemOnce bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pr...
    • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
      Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
    • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
      PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
      PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
    • Programmed Cell Death, organism-specific biosystem (from REACTOME)
      Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
      p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...
    • p75(NTR)-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
      p75(NTR)-mediated signaling, organism-specific biosystem
      p75(NTR)-mediated signaling
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    B cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    T cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    apoptotic process involved in embryonic digit morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
     
    brain development IEA
    Inferred from Electronic Annotation
    more info
     
    cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular process regulating host cell cycle in response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    developmental pigmentation IEA
    Inferred from Electronic Annotation
    more info
     
    ear development IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
     
    intrinsic apoptotic signaling pathway in response to DNA damage IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kidney development IEA
    Inferred from Electronic Annotation
    more info
     
    male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland development IEA
    Inferred from Electronic Annotation
    more info
     
    NOT meiosis I IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    myeloid cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    neurotrophin TRK receptor signaling pathway TAS
    Traceable Author Statement
    more info
     
    odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of IRE1-mediated unfolded protein response TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process TAS
    Traceable Author Statement
    more info
     
    positive regulation of apoptotic process by virus IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of fibroblast apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of intrinsic apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
     
    positive regulation of mitochondrial membrane permeability involved in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
     
    positive regulation of release of cytochrome c from mitochondria IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of release of cytochrome c from mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    post-embryonic organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    programmed cell death TAS
    Traceable Author Statement
    more info
     
    regulation of developmental pigmentation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of organ growth IEA
    Inferred from Electronic Annotation
    more info
     
    response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    spleen development IEA
    Inferred from Electronic Annotation
    more info
     
    thymocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    thymus development IEA
    Inferred from Electronic Annotation
    more info
     
    tube formation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    BIM-BCL-2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    BIM-BCL-xl complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    endomembrane system IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    bcl-2-like protein 11
    Names
    bcl-2 interacting mediator of cell death
    bcl-2 interacting protein Bim
    bcl-2-related ovarian death agonist

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029006.1 RefSeqGene

      Range
      5001..52532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_620

    mRNA and Protein(s)

    1. NM_001204106.1NP_001191035.1  bcl-2-like protein 11 isoform 11

      See identical proteins and their annotated locations for NP_001191035.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11, also known as BimS) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (11) is shorter, compared to isoform 1.
      Source sequence(s)
      AC096670, AI268146, AK290377, AY305714
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:4676
      Bclx_interact; Bcl-x interacting, BH3 domain
    2. NM_001204107.1NP_001191036.1  bcl-2-like protein 11 isoform 12

      See identical proteins and their annotated locations for NP_001191036.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) uses an alternate in-frame splice site in the 5' coding region, contains two alternate internal exons, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (12) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AC096670, AI268146, AK290377, AY423442
      Consensus CDS
      CCDS56132.1
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000481423, ENST00000615946
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:4676
      Bclx_interact; Bcl-x interacting, BH3 domain
    3. NM_001204108.1NP_001191037.1  bcl-2-like protein 11 isoform 13

      See identical proteins and their annotated locations for NP_001191037.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (13) has a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AC096670, AI268146, AK290377, AY423443
      Consensus CDS
      CCDS56135.1
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000482175, ENST00000622509
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:131166
      Bclx_interact; Bcl-x interacting, BH3 domain
    4. NM_001204109.1NP_001191038.1  bcl-2-like protein 11 isoform 14

      See identical proteins and their annotated locations for NP_001191038.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) lacks an internal exon, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (14) has a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AC096670, AI268146, AK290377, AY428962
      Consensus CDS
      CCDS56136.1
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000481030, ENST00000610735
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    5. NM_001204110.1NP_001191039.1  bcl-2-like protein 11 isoform 15

      See identical proteins and their annotated locations for NP_001191039.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) uses an alternate in-frame splice site in the 5' coding region, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (15) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AC096670, AI268146, AK290377, DQ849200
      Consensus CDS
      CCDS56133.1
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:4676
      Bclx_interact; Bcl-x interacting, BH3 domain
    6. NM_001204111.1NP_001191040.1  bcl-2-like protein 11 isoform 16

      See identical proteins and their annotated locations for NP_001191040.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) lacks an in-frame segment in the 5' coding region, and lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (16) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC096670, AI268146, AK290377, DQ849201
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    7. NM_001204112.1NP_001191041.1  bcl-2-like protein 11 isoform 17

      See identical proteins and their annotated locations for NP_001191041.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) lacks an alternate in-frame segment in the 5' coding region, lacks an internal exon, and contains an alternate internal exon, compared to variant 1. The resulting isoform (17) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AC096670, AI268146, AK290377, DQ849202
      Consensus CDS
      CCDS56131.1
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    8. NM_001204113.1NP_001191042.1  bcl-2-like protein 11 isoform 18

      See identical proteins and their annotated locations for NP_001191042.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) lacks an alternate in-frame segment and differs in the 3' UTR and coding sequence, compared to variant 1. The resulting isoform (18) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC096670, AK290377, AW629314
      Consensus CDS
      CCDS74559.1
      UniProtKB/TrEMBL
      A0A0A0MRE7
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000350398, ENST00000357757
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    9. NM_006538.4NP_006529.1  bcl-2-like protein 11 isoform 6

      See identical proteins and their annotated locations for NP_006529.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6, also known as BimL) lacks an in-frame segment in the 5' coding coding region, compared to variant 1. The resulting isoform (6) is shorter, compared to isoform 1.
      Source sequence(s)
      AC096670, AF032458, AI268146, AK290377, BC033694
      Consensus CDS
      CCDS42731.1
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:71106
      Bclx_interact; Bcl-x interacting, BH3 domain
    10. NM_138621.4NP_619527.1  bcl-2-like protein 11 isoform 1

      See identical proteins and their annotated locations for NP_619527.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as BimEL) encodes the longest isoform (1).
      Source sequence(s)
      AC096670, AI268146, BC033694
      Consensus CDS
      CCDS2089.1
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000376943, OTTHUMP00000161927, ENST00000393256, OTTHUMT00000254022
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:131166
      Bclx_interact; Bcl-x interacting, BH3 domain
    11. NM_138622.3NP_619528.1  bcl-2-like protein 11 isoform 2

      See identical proteins and their annotated locations for NP_619528.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as Bim-alpha1) contains an alternate internal exon and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AB071195, AC096670, AI268146, AK290377
      Consensus CDS
      CCDS74560.1
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000481652, ENST00000621302
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:131166
      Bclx_interact; Bcl-x interacting, BH3 domain
    12. NM_138623.3NP_619529.1  bcl-2-like protein 11 isoform 3

      See identical proteins and their annotated locations for NP_619529.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as Bim-ACD and Bim-alpha2) lacks a 5' segment, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AB071196, AC096670, AI268146, AK290377
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000478133, ENST00000620862
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:71106
      Bclx_interact; Bcl-x interacting, BH3 domain
    13. NM_138624.3NP_619530.1  bcl-2-like protein 11 isoform 4

      See identical proteins and their annotated locations for NP_619530.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as Bim-beta1) contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AB071197, AC096670, AI268146, AK290377
      Consensus CDS
      CCDS56134.1
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000479714, ENST00000619294
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    14. NM_138625.3NP_619531.1  bcl-2-like protein 11 isoform 5

      See identical proteins and their annotated locations for NP_619531.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also known as Bim-beta3) uses an alternate splice site in the 5' coding region, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AB071199, AC096670, AI268146, AK290377
      UniProtKB/TrEMBL
      A0A0C4DH20
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    15. NM_138626.3NP_619532.1  bcl-2-like protein 11 isoform 7

      See identical proteins and their annotated locations for NP_619532.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7, also known as Bim-ABC and Bim-beta2) lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (7) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB071198, AC096670, AI268146, AK290377
      Consensus CDS
      CCDS74561.1
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000484360, ENST00000622612
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    16. NM_138627.3NP_619533.1  bcl-2-like protein 11 isoform 8

      See identical proteins and their annotated locations for NP_619533.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8, also known as Bim-A and Bim-beta4) uses an alternate splice site in the 5' coding region, and lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (8) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB071200, AC096670, AI268146, AK290377
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    17. NM_207002.3NP_996885.1  bcl-2-like protein 11 isoform 9

      See identical proteins and their annotated locations for NP_996885.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9, also known as Bim-gamma) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. The resulting isoform (9) has a distinct and shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AA890664, AC096670, AK290377, AY352518
      Consensus CDS
      CCDS2092.1
      UniProtKB/Swiss-Prot
      O43521
      Related
      ENSP00000338374, ENST00000337565
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    18. NM_207003.2NP_996886.1  bcl-2-like protein 11 isoform 10

      See identical proteins and their annotated locations for NP_996886.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10, also known as Bim-alpha3) uses an alternate splice site in the 5' coding region, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (10) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
      Source sequence(s)
      AC096670, AI268146, AK290377, AY305715
      UniProtKB/Swiss-Prot
      O43521
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:4676
      Bclx_interact; Bcl-x interacting, BH3 domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

      Range
      111120618..111168445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510463.1XP_011508765.1  

      Conserved Domains (2) summary
      pfam06773
      Location:2157
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:148183
      Bclx_interact; Bcl-x interacting, BH3 domain
    2. XM_005263556.2XP_005263613.1  

      See identical proteins and their annotated locations for XP_005263613.1

      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:131166
      Bclx_interact; Bcl-x interacting, BH3 domain
    3. XM_005263561.2XP_005263618.1  

      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:71106
      Bclx_interact; Bcl-x interacting, BH3 domain
    4. XM_005263551.1XP_005263608.1  

      Conserved Domains (2) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:225260
      Bclx_interact; Bcl-x interacting, BH3 domain
    5. XM_005263554.1XP_005263611.1  

      Conserved Domains (1) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
    6. XM_005263553.1XP_005263610.1  

      Conserved Domains (2) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:165200
      Bclx_interact; Bcl-x interacting, BH3 domain
    7. XM_005263559.1XP_005263616.1  

      Conserved Domains (2) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:140170
      Bclx_interact; Bcl-x interacting, BH3 domain
    8. XM_005263550.2XP_005263607.1  

      Conserved Domains (2) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:225260
      Bclx_interact; Bcl-x interacting, BH3 domain
    9. XM_005263552.2XP_005263609.1  

      Conserved Domains (2) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:165200
      Bclx_interact; Bcl-x interacting, BH3 domain
    10. XM_005263555.2XP_005263612.1  

      Conserved Domains (2) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:136170
      Bclx_interact; Bcl-x interacting, BH3 domain
    11. XM_011510462.1XP_011508764.1  

      Conserved Domains (1) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
    12. XM_011510465.1XP_011508767.1  

      Conserved Domains (1) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
    13. XM_011510461.1XP_011508763.1  

      Conserved Domains (1) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
    14. XM_011510464.1XP_011508766.1  

      Conserved Domains (1) summary
      pfam06773
      Location:98134
      Bim_N; Bim protein N-terminus
    15. XM_005263557.3XP_005263614.1  

      See identical proteins and their annotated locations for XP_005263614.1

      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:131166
      Bclx_interact; Bcl-x interacting, BH3 domain

    RNA

    1. XR_244801.1 RNA Sequence

    2. XR_922830.1 RNA Sequence

    3. XR_922829.1 RNA Sequence

    4. XR_922828.1 RNA Sequence

    5. XR_244802.2 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      111882732..111930286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)