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IMPG2 interphotoreceptor matrix proteoglycan 2 [ Homo sapiens (human) ]

Gene ID: 50939, updated on 11-Sep-2014
Official Symbol
IMPG2provided by HGNC
Official Full Name
interphotoreceptor matrix proteoglycan 2provided by HGNC
Primary source
HGNC:HGNC:18362
See related
Ensembl:ENSG00000081148; HPRD:06135; MIM:607056; Vega:OTTHUMG00000159091
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RP56; IPM200; SPACRCAN
Summary
The protein encoded by this gene binds chondroitin sulfate and hyaluronan and is a proteoglycan. The encoded protein plays a role in the organization of the interphotoreceptor matrix and may promote the growth and maintenance of the light-sensitive photoreceptor outer segment. Defects in this gene are a cause of retinitis pigmentosa type 56 and maculopathy, IMPG2-related.[provided by RefSeq, Mar 2011]
See IMPG2 in Epigenomics, MapViewer
Location:
3q12.2-q12.3
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 3 NC_000003.12 (101222546..101320575, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (100941390..101039419, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ABI family, member 3 (NESH) binding protein Neighboring gene family with sequence similarity 175, member A pseudogene Neighboring gene ACTR3 pseudogene 3 Neighboring gene SUMO1/sentrin specific peptidase 7 Neighboring gene zinc finger protein 90 pseudogene 1 Neighboring gene protein FAM136A-like

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
extracellular matrix structural constituent TAS
Traceable Author Statement
more info
PubMed 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
hyaluronic acid binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
visual perception TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
proteinaceous extracellular matrix TAS
Traceable Author Statement
more info
PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
 
Preferred Names
interphotoreceptor matrix proteoglycan 2
Names
interphotoreceptor matrix proteoglycan 2
IPM 200
interphotoreceptor matrix proteoglycan IPM 200
interphotoreceptor matrix proteoglycan of 200 kDa
sialoprotein associated with cones and rods proteoglycan

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028284.1 

    Range
    5001..103030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016247.3NP_057331.2  interphotoreceptor matrix proteoglycan 2 precursor

    See proteins identical to NP_057331.2

    Status: REVIEWED

    Source sequence(s)
    AB593127, AC093008, BM671068, BX953286
    Consensus CDS
    CCDS2940.1
    UniProtKB/TrEMBL
    F1T0J3
    UniProtKB/Swiss-Prot
    Q9BZV3
    Related
    ENSP00000193391, OTTHUMP00000214052, ENST00000193391, OTTHUMT00000353256
    Conserved Domains (1) summary
    pfam01390
    Location:8981000
    SEA; SEA domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000003.12 

    Range
    101222546..101320575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000135.1 

    Range
    98310078..98408005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 

    Range
    100904435..101002378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)