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Fyb FYN binding protein [ Mus musculus (house mouse) ]

Gene ID: 23880, updated on 17-Mar-2015
Official Symbol
Fybprovided by MGI
Official Full Name
FYN binding proteinprovided by MGI
Primary source
MGI:MGI:1346327
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ADAP; Slap130; p120/130; p120/p130; FYB-120/130; B630013F22Rik
Summary
The protein encoded by this gene is an adapter molecule that affects T cell receptor signaling and contains multiple protein-protein interaction domains. It is thought to couple T cell receptor stimulation with activation of integrin function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Orthologs
See Fyb in MapViewer
Location:
15; 15 A1
Exon count:
21
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 15 NC_000081.6 (6522797..6665608)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (6529871..6613312)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene disabled 2, mitogen-responsive phosphoprotein Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene complement component 9 Neighboring gene uncharacterized LOC102632231 Neighboring gene prohibitin pseudogene Neighboring gene RPTOR independent companion of MTOR, complex 2 Neighboring gene uncharacterized LOC105245877 Neighboring gene uncharacterized LOC105245878 Neighboring gene oncostatin M receptor

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
NOT mast cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
FYN-binding protein
Names
FYN-binding protein
FYN binding protein FYB-130
FYN-T-binding protein
SLP-76-associated phosphoprotein
adhesion and degranulation promoting adaptor protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278269.1NP_001265198.1  FYN-binding protein isoform 2

    See proteins identical to NP_001265198.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AC158901, AC161196, AK137907
    UniProtKB/Swiss-Prot
    O35601
    Conserved Domains (2) summary
    cd11867
    Location:684755
    hSH3_ADAP; Helically extended Src Homology 3 domain of Adhesion and Degranulation-promoting Adaptor Protein
    pfam07653
    Location:503557
    SH3_2; Variant SH3 domain
  2. NM_011815.5NP_035945.1  FYN-binding protein isoform 1

    See proteins identical to NP_035945.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC158901, AC161196
    Consensus CDS
    CCDS37031.1
    UniProtKB/TrEMBL
    B2RUR0
    UniProtKB/Swiss-Prot
    O35601
    Conserved Domains (2) summary
    cd11867
    Location:730801
    hSH3_ADAP; Helically extended Src Homology 3 domain of Adhesion and Degranulation-promoting Adaptor Protein
    pfam07653
    Location:503557
    SH3_2; Variant SH3 domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p3 C57BL/6J

    Range
    6522797..6665608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245328.1XP_011243630.1  

    Conserved Domains (2) summary
    cd11867
    Location:748819
    hSH3_ADAP; Helically extended Src Homology 3 domain of Adhesion and Degranulation-promoting Adaptor Protein
    pfam07653
    Location:513567
    SH3_2; Variant SH3 domain
  2. XM_011245329.1XP_011243631.1  

    Conserved Domains (2) summary
    cd11867
    Location:702773
    hSH3_ADAP; Helically extended Src Homology 3 domain of Adhesion and Degranulation-promoting Adaptor Protein
    pfam07653
    Location:513567
    SH3_2; Variant SH3 domain
  3. XM_006519982.1XP_006520045.1  

    Conserved Domains (2) summary
    cd11867
    Location:740811
    hSH3_ADAP; Helically extended Src Homology 3 domain of Adhesion and Degranulation-promoting Adaptor Protein
    pfam07653
    Location:513567
    SH3_2; Variant SH3 domain
  4. XM_006519985.1XP_006520048.1  

    Conserved Domains (2) summary
    cd11867
    Location:694765
    hSH3_ADAP; Helically extended Src Homology 3 domain of Adhesion and Degranulation-promoting Adaptor Protein
    pfam07653
    Location:513567
    SH3_2; Variant SH3 domain
  5. XM_011245330.1XP_011243632.1  

    Conserved Domains (1) summary
    pfam07653
    Location:513567
    SH3_2; Variant SH3 domain
  6. XM_006519983.1XP_006520046.1  

    Conserved Domains (2) summary
    cd11867
    Location:738809
    hSH3_ADAP; Helically extended Src Homology 3 domain of Adhesion and Degranulation-promoting Adaptor Protein
    pfam07653
    Location:503557
    SH3_2; Variant SH3 domain
  7. XM_006519986.1XP_006520049.1  

    Conserved Domains (2) summary
    cd11867
    Location:308379
    hSH3_ADAP; Helically extended Src Homology 3 domain of Adhesion and Degranulation-promoting Adaptor Protein
    pfam07653
    Location:73127
    SH3_2; Variant SH3 domain

RNA

  1. XR_874995.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000037.1 Alternate Mm_Celera

    Range
    6428692..6514206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)