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    Myd88 myeloid differentiation primary response gene 88 [ Mus musculus (house mouse) ]

    Gene ID: 17874, updated on 1-Sep-2015
    Official Symbol
    Myd88provided by MGI
    Official Full Name
    myeloid differentiation primary response gene 88provided by MGI
    Primary source
    MGI:MGI:108005
    See related
    Ensembl:ENSMUSG00000032508; Vega:OTTMUSG00000016655
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Orthologs
    See Myd88 in Epigenomics, MapViewer
    Location:
    9 F3; 9 71.33 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (119335988..119340040, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (119245106..119249158, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 (organic cation transporter), member 13b, pseudogene Neighboring gene oxidative-stress responsive 1 Neighboring gene acetyl-Coenzyme A acyltransferase 1A Neighboring gene xylulokinase homolog (H. influenzae)

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    TIR domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    Toll binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-1 receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    3'-UTR-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    MyD88-dependent toll-like receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    MyD88-dependent toll-like receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Toll signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of endothelial intestinal barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    immunoglobulin mediated immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    induced systemic resistance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    lipopolysaccharide-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of growth of symbiont in host IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of chemokine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of interleukin-17 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-23 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of lymphocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tumor necrosis factor production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of chemokine (C-X-C motif) ligand 1 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of chemokine (C-X-C motif) ligand 2 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neutrophil migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    response to lipopolysaccharide IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to molecule of fungal origin IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to peptidoglycan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein serine/threonine kinase signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    type I interferon biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    myeloid differentiation primary response protein MyD88

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010851.2NP_034981.1  myeloid differentiation primary response protein MyD88

      See identical proteins and their annotated locations for NP_034981.1

      Status: PROVISIONAL

      Source sequence(s)
      BC005591
      Consensus CDS
      CCDS23612.1
      UniProtKB/Swiss-Prot
      P22366
      UniProtKB/TrEMBL
      Q3U7M4
      Related
      ENSMUSP00000035092, OTTMUSP00000018013, ENSMUST00000035092, OTTMUST00000040319
      Conserved Domains (2) summary
      smart00255
      Location:161296
      TIR; Toll - interleukin 1 - resistance
      cd08312
      Location:29106
      Death_MyD88; Death domain of Myeloid Differentation primary response protein MyD88

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

      Range
      119335988..119340040
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000031.1 Alternate Mm_Celera

      Range
      119805118..119809170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)